--- Log opened Thu Jul 12 00:00:14 2018
00:03 < nmz787> .tell yashgaroth do primer microarrays suffer from mispriming mid-fragment? the big-ass molecule simply being a huge plane of glass seems like the best you're gonna do in terms of this idea
00:03 < yoleaux> nmz787: I'll pass your message to yashgaroth.
00:05 < nmz787> .tell yashgaroth my guess is mis-priming mid-fragment would be affected by the length of the affixed primer, and the radius of curvature that the ssDNA could bend
00:05 < yoleaux> nmz787: I'll pass your message to yashgaroth.
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01:09 < archels> "it’s an old saw that lesioning the brains of your customers with glutamatergic excitotoxins is bad for business"
01:22 < mrdata> worth remembering
01:24 < nmz787> mmm, cheetos
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01:41 < archels> .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735096/
01:41 < yoleaux> Genes mirror geography within Europe
02:04 < fenn> i'm pretty sure the "chinese restaurant syndrome" was a result of confusion over hidden use of the then-illegal-to-import szechuan peppercorn in their recipes, and then MSG took the blame
02:04 < nmz787> those peppercorns are delicious
02:05 < fenn> possibly allergies to the szechuan pepper
02:05 < nmz787> they make the food 'pop'
02:05 < nmz787> huh
02:05 < nmz787> maybe
02:05 < nmz787> MSG shows good effects on elderly people in old age homes
02:05 < nmz787> via 'gut clearing' as I recall from the paper I read years ago
02:06 < fenn> yum
02:06 < nmz787> basically your body is like 'meat/aminos' and then better works to absorb the food intake
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03:56 < archels> dear lord, they're even giving a "Fortran for Scientific Computing" course
03:56 < archels> it's not going to die if you keep giving courses about it, people!
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05:56 < kanzure> .tw https://twitter.com/decentrali/status/1017139425019613185
05:56 < yoleaux> @peterktodd @kanzure @orionwl @patmillertime @finway2 @pierre_rochard @BitcoinMerges even skipping fabrication equipment and looking at equally necessary calibration/observation of things you make for visual/other feedback via "microscopes" like TEM's (or SEMs), there's real scary complexity. e.g. electrons move so fast you have to correct for relativity: https://pbs.twimg.com/media/Dh2a1GRXkAAzLqx.jpg (@decentrali, in reply to tw:
05:56 < yoleaux> 1017134138321616896)
05:56 < kanzure> .tw https://twitter.com/orionwl/status/1017132724853800960
05:56 < yoleaux> @kanzure @decentrali @patmillertime @finway2 @pierre_rochard @BitcoinMerges The machines are expensive ($mil+). On the other hand it's extremely hard to position, and prevent pattern distortion at such small scales, a lot of highly paid physicists mathematicians and programmers working on it. That explains the price I guess. As well as precision optics… (@orionwl, in reply to tw:1017131341794676737)
05:57 < kanzure> .tw https://twitter.com/f_borretti/status/1017132982468046853
05:57 < yoleaux> @orionwl @kanzure @patmillertime @finway2 @pierre_rochard @BitcoinMerges TTL logic might be a reasonable compromise. Vastly less equipment + CAPEX than a home fab, but worse performance by a few decades. (@f_borretti, in reply to tw:1017056698345906176)
05:57 < kanzure> .tw https://twitter.com/peterktodd/status/1017133200114573313
05:57 < yoleaux> @kanzure @orionwl @decentrali @patmillertime @finway2 @pierre_rochard @BitcoinMerges Having worked in a not-unlike field before and seen the endless complexities first hand, I wouldn't be surprised to learn that litographic equipment is far more complex than appears at first glance. Gravity gradiometry was an endless parade of mind-boggling problems. (@peterktodd, in reply to tw:1017131341794676737)
05:57 < kanzure> .tw https://twitter.com/peterktodd/status/1017133683554185216
05:57 < yoleaux> @kanzure @orionwl @decentrali @patmillertime @finway2 @pierre_rochard @BitcoinMerges All solvable with hard work, but we're probably talking hundreds of man-years worth of concentrated effort. (@peterktodd, in reply to tw:1017133200114573313)
05:58 < kanzure> .tw https://twitter.com/orionwl/status/1017284084723265537
05:58 < yoleaux> @f_borretti @kanzure @patmillertime @finway2 @pierre_rochard @BitcoinMerges I've seen some cool projects based on discrete TTL ICs, but an 8-bit CPU is already a daunting affair, I'm afraid for a 32-bit one you'd have to clear a city-sized area first to replace with a wire jungle. (@orionwl, in reply to tw:1017132982468046853)
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06:03 < kanzure> .tw https://twitter.com/kanzure/status/1017393041869590528
06:03 < yoleaux> @mHaGqnOACyFm0h5 @orionwl @provoost @decentrali @patmillertime @finway2 @pierre_rochard @BitcoinMerges Nah biological cells would never be practical and they are a myth (@kanzure, in reply to tw:1017362155539136514)
06:03 < kanzure> .tw https://twitter.com/mHaGqnOACyFm0h5/status/1017393850640367622
06:03 < yoleaux> @kanzure @orionwl @provoost @decentrali @patmillertime @finway2 @pierre_rochard @BitcoinMerges but what if we just increase the cell size? the square cube law is an AXA ploy (@mHaGqnOACyFm0h5, in reply to tw:1017393041869590528)
06:03 < kanzure> makes sense
06:04 < kanzure> i knew it all along
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06:09 < JayDugger> .tw https://twitter.com/kanzure/status/1017393540849197056
06:09 < yoleaux> Biology is the ultimate decentralization. Every cell in your body has a copy of the genetic chain. A library of tools to make and operate an entire person. Personal freedom is biological freedom. What could be more decentralized than that? (@kanzure)
06:10 < JayDugger> You could extend that analogy in ways that undermine it, but still, pretty nicely said.
06:20 < kanzure> .tw https://twitter.com/orionwl/status/1017394467500904450
06:20 < yoleaux> @kanzure @mHaGqnOACyFm0h5 @provoost @decentrali @patmillertime @finway2 @pierre_rochard @BitcoinMerges Such a complex, chaotic, disorganized mess as a biological cell could never work, least do anything useful. Biology is a hoax. (@orionwl, in reply to tw:1017393041869590528)
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06:25 < kanzure> .tw https://twitter.com/GeneticJen/status/1017385716152766464
06:25 < yoleaux> 7. Also also also the rods and cones of the horseshoe crab's eyes are the biggest known, 100 times bigger than ours. Just a bit excessive really. Still can't do a magic eye puzzle though (@GeneticJen, in reply to tw:1017385376556683265)
06:25 < kanzure> what is the advantage of large rods and cones?
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06:49 < archels> to make their eyes more sensitive in low-light conditions, I suppose
06:57 < kanzure> .title https://news.ycombinator.com/item?id=17509755
06:57 < yoleaux> Bulletproofs – Short zero-knowledge arguments of knowledge | Hacker News
06:57 < kanzure> haskell implementation https://github.com/adjoint-io/bulletproofs
07:00 < kanzure> .tw https://twitter.com/Germinarch/status/1017407270605369344
07:00 < yoleaux> @kanzure Roger Ver's cells, in addition to DNA, store his bank account information, social security number, insurance policy and much more, because we all know that his cells are larger than ours. (@Germinarch, in reply to tw:1017393540849197056)
07:00 < kanzure> hmm.
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08:29 < JayDugger> More likely empty vacuoles occupy most of those large cells.
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--- Log closed Thu Jul 12 09:09:02 2018
--- Log opened Thu Jul 12 09:09:02 2018
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10:02 < kanzure> "a big chunk of genetic engineering is going to be replacing all this parallel execution distributed system nonsense with more linear-interactable systems, like by inserting barcodes to gate different regulatory networks and features rather than using a thousand different organic molecules in metabolism or whatever.."
10:02 < kanzure> oh i forgot about barcode-gating of genetic regulators
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10:38 < archels> interesting point
10:52 < nmz787> while your body's cells may be distributed, there isn't really a proof of fidelity among the DNA from one cell to another. My skin might be mutated much more than some more sheltered organ like the brain. Cross-cell DNA repair could be interesting.
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11:56 < kanzure> .wik medipix
11:56 < yoleaux> "Medipix is a family of photon counting and particle tracking pixel detectors developed by an international collaboration, hosted by CERN." — https://en.wikipedia.org/wiki/Medipix
11:59 < kanzure> https://www.marsbioimaging.com/mars/media-pack/
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12:31 < kanzure> d4d4b3d2e2c220cd86ec00b84ed58289946995aa1bf5f006d0de530b1c7d9403  bitcoin-dev-2010-2015.txt.xz
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13:17 < l_wl> im at noisebridge
13:17 < l_wl> anyone else here
13:17 < l_wl> ?
13:17 < kanzure> no
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20:22 < kanzure> welp.
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--- Log closed Fri Jul 13 00:00:15 2018