--- Log opened Mon Jul 16 00:00:17 2018
01:07 < fenn> redlegion: what's going on with your connection?
04:52 < redlegion> fenn: not sure. I'll have to look into it.
05:15 < kanzure> well, stop it
05:20 < kanzure> http://www.amscope.com/applications/embryology/in-vitro-fertilization.html
05:21 < kanzure> i wonder if expansion microscopy works with embryos and whether it damages the embryo
05:22 < kanzure> "Progress and remaining challenges in high-throughput volume electron microscopy" https://www.sciencedirect.com/science/article/pii/S0959438817303021
05:27 < kanzure> "Learning cellular morphology with neural networks" https://www.biorxiv.org/content/biorxiv/early/2018/07/06/364034.full.pdf
05:57 < kanzure> designer baby video thing https://www.youtube.com/watch?v=jAhjPd4uNFY
05:57 < kanzure> ivf documentary https://www.youtube.com/watch?v=Y_iTgC7z3u8
06:02 < kanzure> "Preliminary results of the first human uterus transplantation from a multiorgan donor" https://www.sciencedirect.com/science/article/pii/S0015028212022546
06:03 < kanzure> "Uterus transplantation from a deceased donor" https://www.fertstert.org/article/S0015-0282(13)00741-3/pdf
06:10 < kanzure> wait.. round spermatid injection works?
06:12 < kanzure> because this one was able to do in vitro generation of round spermatids in nonhuman primates https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814948/
06:15 < kanzure> i'm gonna be kinda angry if it turns out that human in vitro spermatogenesis already works up to round spermatid stage and researchers have been trying to get complete differentiation
06:19 < kanzure> "Completion of meiosis in human primary spermatocytes through in vitro coculture with Vero cells" https://www.sciencedirect.com/science/article/pii/S0015028202048331 (2003)
06:19 < kanzure> ....
06:21 < kanzure> "In the mouse, round spermatid injection (ROSI) has been routinely successful but its use in humans is controversial. Whether human ROSI and assisted fertilization involving younger spermatogenic cells are medically safe must be the subject of further investigations." from https://www.sciencedirect.com/science/article/pii/S1472648310609479
06:21 < kanzure> .wik round spermatid injection
06:21 < yoleaux> "The spermatid is the haploid male gametid that results from division of secondary spermatocytes.  As a result of meiosis, each spermatid contains only half of the genetic material present in the original primary spermatocyte." https://en.wikipedia.org/wiki/Spermatid
06:21 < kanzure> bah
06:22 < solene> interesting topic
06:27 < kanzure> Suzukiet al (2003) might have tested round spermatid injection and got negative results, unclear i haven't checked
06:31 < kanzure> "Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of cryptorchid patients" https://www.sciencedirect.com/science/article/pii/S2213671114002586
06:32 < kanzure> "Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system" https://www.nature.com/articles/s41418-017-0015-1
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06:45 < kanzure> not clear to me if they were able to do stem cell proliferation to make a larger culture
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06:53 < kanzure> ~10% fertilization success rate isn't great but not bad..
10:04 < kanzure> zalgo: be greeted
10:46 < zalgo> kanzure: greeting successful
13:13 < archels> https://ai.googleblog.com/2018/07/improving-connectomics-by-order-of.html
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13:20 < kanzure> .title
13:20 < yoleaux> Google AI Blog: Improving Connectomics by an Order of Magnitude
20:00 < kanzure> blort
20:04 < nmz787> mm bopp
20:14 < kanzure> 19:11 < Obormot\Sirius> Ok, is it just me or is the idea of assigning some probability to some ethical theory being true... a really, really bizarre concept?
20:14 < kanzure> 19:11 < Filipe_> ah, but that's the fun
20:14 < kanzure> 19:16 < Obormot\Sirius> I honestly can't understand what this is saying. What does any of this mean? I mean, he's assigning some probability to average utilitarianism being true, and another to total utilitarianism being true
20:14 < kanzure> 19:16 < Obormot\Sirius> And then something about utility functions, which you're weighting by the probability of each ethical framework being true... and... wtf???
21:53 < fenn> it's about as weird as assigning probabilities to mathematical statements
21:54 < fenn> the probability that the nth digit of pi is 1, etc
21:54 < fenn> of course "being true" is a can of worms in itself
21:54 < fenn> wrt ethical statements
--- Log closed Tue Jul 17 00:00:18 2018