--- Log opened Fri Aug 03 00:00:29 2018
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00:50 < nmz787> hmm, the prequel to that retracted electronic-polymerase paper that was retracted... this one actually goes through their methods in decent detail... and wasn't retracted :O         https://www.nature.com/articles/nnano.2012.7
00:50 < nmz787> .title
00:50 < yoleaux> A protein transistor made of an antibody molecule and two gold nanoparticles | Nature Nanotechnology
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09:59 < nmz787> blah,
09:59 < nmz787> need to find a nanofluidics expert who has time for a new project
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10:39 < nmz787> https://www.nature.com/articles/d41586-018-05857-9
10:39 < nmz787> .title
10:39 < yoleaux> Entire yeast genome squeezed into one lone chromosome
10:40 < nmz787> "“That was the biggest shocker — that you can just get away with this and yeast seem to shrug its shoulders,” says Jef Boeke, a geneticist at New York University whose team jammed the yeast genome onto a pair of chromosomes"
10:40 < nmz787> "But while Boeke’s strain underwent normal asexual reproduction and grew as efficiently as 16-chromosome strains, the lone-chromosome yeast divided more slowly."
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14:33 < sachy> hi all, like a year ago there was someone who used in-vitro Cas9 to enhance his dermal cells to synthetize fuorescein(?) and then he injected them back to himself... Sadly I have lost a reference for it... Does anyone remember the blog/source?
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14:51 < nmz787> sachy: probably josiah zayner
14:52 < nmz787> so glad I ran across this: https://github.com/computerlyrik/dymoprint
14:53 < nmz787> sachy: yeah, he did a fluorescent gene attempt https://www.buzzfeednews.com/article/stephaniemlee/this-biohacker-wants-to-edit-his-own-dna
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15:00 < sachy> nmz787: thanks! :)
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15:52 < kanzure> monochromosome is cool
15:57 < nmz787> "1 is the lonliest number..."
16:00 < nmz787> kanzure: have you seen any papers that rather than trying to slow down DNA translocation through nanopores, tries to increase the bandwidth of the system/scheme instead?
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16:02 < nmz787> kanzure: they're saying things like "we used 120mV and the DNA went real fast, too fast for our detector limit of ~10 kHz, but if we use less voltage then we lose sensitivity on the measurement aspect (current-based)"
16:03 < nmz787> kanzure: but the obvious next question is something like "well why not just chop up the voltage, i.e. PWM"
16:12 < kanzure> https://github.com/Chia-Network/bls-signatures
16:12 < kanzure> nmz787: i think hua wang would be a good person to talk with about this. or kent kemmish.
16:12 < kanzure> i don't have any answers for you about this
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16:22 < nmz787> even dumber things like "reduce the wire length between the fluidic cell and the amplifier input" would be an easy start
16:38 < ebowden> What circuits can even record data at that high a frequency?
16:41 < ebowden> Oh, derp.
16:41 < ebowden> kHz, not gHz.
16:42 < ebowden> Yeah, LOTS of room for improvement there.
16:44 < nmz787> unless there's something about the electrochemistry... *grumble grumble* debye layer *grumble*
16:44 < nmz787> like the limitation is at the electrode itself.. but...
16:56 < ebowden> It would suck if the nanopore itself just couldn't keep up.
17:07 < nmz787> I guess this is what materials scientists and physical chemists are for
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17:22 < kanzure> "Mainstay: enabling trustless immutability in federated sidechains" https://www.commerceblock.com/wp-content/uploads/2018/03/commerceblock-mainstay-whitepaper.pdf
17:25 < kanzure> "DIZK: A distributed zero knowledge proof system" https://eprint.iacr.org/2018/691
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17:42 < kanzure> https://github.com/herumi/bls
17:44 < nmz787> .title
17:44 < yoleaux> GitHub - herumi/bls
17:45 < kanzure> cryptography stuff.
17:45 < kanzure> are we still on registered-only?
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18:25 < nmz787> anyone here used a google glass?
18:25 < nmz787> if so, is it worth buying one for handsfree web surfing? like while walking?
18:26 < nmz787> or is there something that is better in 2018?
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18:46 < fenn> you can type /mode ##hplusroadmap to see the current flags. we're still on +r
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21:57 < mrdata> can the channel logs be flushed of the spam?
21:58 < mrdata> or else search engines could up the score of the links which would be bad
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22:37 < nmz787> fenn ^ ?
23:40 < mrdata> https://freenode.net/news/spambot-attack
23:41 < mrdata> about 1400 freenode channels keep logs
23:41 < mrdata> and in due course those logs ought to be purged of the spam or else search engines will promote the links in search results
23:42 < mrdata> law enforcement is involved. freenode needs a court order to take down the offending domains, probably
23:42 < mrdata> presumably the perpetrators are working hard to obscure their identities
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--- Log closed Sat Aug 04 00:00:30 2018