--- Log opened Mon Aug 06 00:00:32 2018
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00:06 < archels> reset
00:06 < archels> my session, it lives! please ignore
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07:02 < kanzure> minneapolis synthetic biology workshop thing http://buildacell.io/engineering/workshop3/
07:03 < kanzure> hmm these seem to be the docs they want to edit today-- protein translation https://docs.google.com/document/d/1kOIWLbgQ7e_-2gTSVKmx456W7D9HuHjjyVQOEzqh9_U/edit  roadmap https://docs.google.com/document/d/1m1xUP-_QpMCV1cCnDg1fLSuq9pmcF9f4_JVBZ-G3dPU/edit  in silico cell simulation https://docs.google.com/document/d/1qimivARdrlG4PvTgv8CFd_ou7vg_iM7MR8TmqFn54E8/edit and minimal essential genes ...
07:03 < kanzure> ...https://docs.google.com/document/d/16DNK75pduGodLD8pg_NQSNjhg8QnHzXP3DEFW8cbZ5M/edit
07:04 < kanzure> also they are on slack and you can pester them http://buildacell-invite.herokuapp.com/
07:05 < kanzure> https://twitter.com/buildacell
07:06 < kanzure> "Electric-field manipulation of a compartmentalized cell-free gene expression reaction" https://pubs.acs.org/doi/10.1021/acssynbio.8b00160
07:07 < kanzure> "Here, we applied a localized electric field gradient at megahertz frequency to manipulate a cell-free gene-expression reaction in a DNA compartment on a chip. We broke the spatial symmetry of a homogeneous reaction in the compartment by creating a trap for macromolecules in a region of maximal field intensity localized 50 μm from immobilized DNA. Free of biochemical regulation, we ...
07:07 < kanzure> ...demonstrated protein synthesis oscillations by on/off switching of the electric field. In response to the field, ribosomes, RNA polymerases, and nascent RNA and proteins accumulated in the trap, and were then depleted from the DNA region where gene expression occurred. The resulting reduction in the rate of protein synthesis recovered back to steady-state when the field was off. The ...
07:07 < kanzure> ...combination of electric field with compartmentalized cell-free gene expression reactions creates a simple, label-free approach for controlling biomolecules in space and time, opening possibilities for hybrid biological systems with a bioelectronic interface based on minimal biological parts design."
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07:21 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=89a85411 Bryan Bishop: better olfactory receptor science >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
07:22 < kanzure> https://www.bioscentric.com/cracking-the-olfactory-code/   mentions the olfactory-ligand multiplex assay stuff from kosuri lab
07:23 < kanzure> "A perspective on cortical layering and layer-spanning neuronal elements" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056619/
07:24 < kanzure> .tw https://twitter.com/KordingLab/status/1025854985307910145
07:24 < yoleaux> Towards a computational role of the cortical layers. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056619/ potentially highly relevant for the deep learning/ neuroscience link. (@KordingLab)
07:25 < kanzure> "Ultrastructural, molecular and functional mapping of GABAergic synapses on dendritic spines and shafts of neocortical pyramidal neurons" https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy143/5065100?guestAccessKey=0ad0f2ee-c732-4357-aee9-0c5dcec87ae4  https://twitter.com/yusterafa/status/1025777288783253510
07:25 < kanzure> "Using two-photon uncaging of GABA, intracellular labeling with gerphyrin intrabodies, and focused ion beam milling with scanning electron microscopy, we find that most (96–98%) spines lack GABAergic synapses, although they still display GABAergic responses, potentially due to extrasynaptic GABA receptors. We conclude that GABAergic inputs, in practice, contact dendritic shafts and likely ...
07:26 < kanzure> ...control clusters of excitatory inputs, defining functional zones on dendrites."
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07:27 < superkuh> That's surprising.
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08:36 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=55ab2774 Bryan Bishop: some other random stuff >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
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08:50 < l_wl> Why would the Rotation curve of a typical spiral galaxy: predicted (A) and observed (B). Be different. e.g: Milky Way arms move faster at the further out from the center but spin is the same
08:55 < mrdata> l_wl, the mass is wrong
08:55 < mrdata> especially at large distance from galactic centre
08:57 < mrdata> which points to existence of dark matter
08:58 < l_wl> https://scontent-iad3-1.xx.fbcdn.net/v/t1.15752-9/38650374_723998477938507_8446886016102432768_n.jpg?_nc_cat=0&oh=563f68cf4ca8b50b90823a2d1b2ff828&oe=5BD1D70C
08:58 < l_wl> I've been reading about meerKAT and tryna update myself on some physics - does this seem right?
09:01 < mrdata> orbital velocity at the outer edge is slower than it is near the core; just not as much slower as newtonian physics would give you
09:03 < l_wl> Ye that makes sense because at the edge the galaxy meets again so much of the velocity goes from x to y axis
09:04 < l_wl> Its like a rough spherical shape
09:06  * mrdata naps
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12:52 < kanzure> uhh, would fetal cryonics get around the abortion-is-murder problems?
12:55 < andytoshi> i think yes (can ask my mom if you really want an answer :P), but having massive farms of frozen viable fetuses that nobody was looking too closely at would probably be worse, from a PR standpoint
13:20 < TMA> not likely. the abortion-is-murder is not based on any coherent world view besides 'how do I feel about it?' introspection
13:21 < TMA> s/coherent/rational/
13:35 < andytoshi> i'm fascinated to know what your {coherent, rational} model for identifying and valuing human lives is
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13:56 < kanzure> andytoshi: i think the anti-abortion people might be willing to compromise and say that while abortion farms look disgusting, it's better than murder.
14:09 < nmz787> well I officially have submitted a proposal to the government... what a whirlwind of paperwork :O
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14:10 < kanzure> fetal cryonics https://jetpress.org/v25.1/minerva.htm
14:11 < kanzure> nmz787: cool. that's a lot of work. take a break now.
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14:33 < nmz787> kanzure: yes, planning to leave the house today!
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17:22 < kanzure> "Fully integrated silicon probes for high-density recording of neural activity" https://www.nature.com/articles/nature24636
17:22 < kanzure> http://www.ucl.ac.uk/neuropixels
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18:03 < fenn> fetal cryonics is immoral because you're just making more damaged substandard humans that have to live out their lives with all the mutations and accidents nature has given them
18:03 < fenn> nevermind the inevitable side effects of bad cryonics protocols and execution of those protocols
18:03 < fenn> (assuming you can ever really unfreeze someone)
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19:57 < kanzure> fenn: yes but fetal uploading..?
20:04 < fenn> i'm not sure what would be the point
20:05 < fenn> the paper was about freezing with the intent to unfreeze
20:07 < fenn> this seems like a good way to make enemies with no particular upside
20:07 < fenn> abortion people will see it as killing a baby
20:09 < fenn> if by some miracle you succeed, you will now have a baseline human with no experiences, which could have easily been created by simply fertilizing an egg and waiting a few weeks
20:09 < kanzure> well presumably you'd get the abortion people to pay for the development of fetal cryonics and/or for the actual storage
20:09 < kanzure> sorry i mean the anti-abortion people would pay for it
20:09 < fenn> people who care about abortion either way
20:10 < fenn> pro-abortion people will see it as an invasion of a woman's right to something something
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20:13 < kanzure> AppleSentry: be greeted
20:13 < AppleSentry> hello world and @everyone
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20:39 < fenn> my above comments make it seem like i'm anti-human or anti-population, but what i meant was it's better to make improved humans than baseline humans
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22:39 < maaku> TMA: I believe abortion is murder. Thanks for not taking my position seriously and accusing me of incoherent world views.
22:39 < maaku>  fetal cryonics would get around the abortion-is-murder concerns for me
22:41 < maaku> fenn: by that logic it would be better to murder people with bad genes now and replace them with genetically engineered people, if that were cheaper/easier to do
22:41 < maaku> (which is a counter-factual scenario, but a telling one)
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--- Log closed Tue Aug 07 00:00:33 2018