--- Log opened Tue Oct 09 00:00:32 2018
00:47 < kanzure> .tw https://twitter.com/wyssinstitute/status/1044977433680769025
00:47 < yoleaux> Peng Yin receives @NIH_CommonFund award to accelerate Human BioMolecular Atlas Program. The program harnesses DNA nanotechnology-driven barcoding and signal amplification technologies to map cells and their functions in the human body https://buff.ly/2QXHqIy @NIH https://pbs.twimg.com/media/DoCBcBvXkAAq6iA.jpg (@wyssinstitute)
00:48 < kanzure> "Deep generative models of genetic variation capture mutation effects" https://www.biorxiv.org/content/early/2017/12/18/235655.1 https://github.com/debbiemarkslab/DeepSequence
00:50 < kanzure> "High-throughput mapping of mesoscale connectomes in individual mice" https://www.biorxiv.org/content/early/2018/09/20/422477 https://twitter.com/biorxiv_neursci/status/1042764302376206336
00:52 < kanzure> .tw https://twitter.com/Addgene/status/1039605516807405569
00:52 < yoleaux> New plasmids from the lab of @eboyden3 Temporally precise single-cell-resolution #optogenetics https://hubs.ly/H0dJGdS0 https://pbs.twimg.com/media/Dm1rtMjU8AA2dUE.jpg (@Addgene)
00:55 < kanzure> .tw https://twitter.com/anderssandberg/status/1038440451689205761
00:55 < yoleaux> A friend pointed out that the aestivation hypothesis is the ultimate Marshmallow Test: you can either have a marshmallow now, or wait a trillion years and get 10^30 marshmallows. https://arxiv.org/abs/1705.03394 (@anderssandberg)
00:56 < kanzure> .tw https://twitter.com/KarlDeisseroth/status/1034850765444022272
00:56 < yoleaux> How do channelrhodopsins work as molecules? High-resolution mechanisms of selectivity, speed & color https://rdcu.be/5rer, https://rdcu.be/5rel. Thanks to a super team- 6 wonderful intense yrs after our initial 2012 structure of the light-gated pore. Proteins are beautiful. https://twitter.com/Yoon_Seok_Kim/status/1034849137638817793 (@KarlDeisseroth)
00:56 < kanzure> .tw https://twitter.com/Yoon_Seok_Kim/status/1034849137638817793
00:56 < yoleaux> Our papers about insights into selectivity, gating, spectra, and many interesting aspects about channelrhodopsins are out @nature, as two Articles! Enormous kudos to my incredible teammates, namely @emeKato and @KarlDeisseroth! https://tinyurl.com/yba95eag https://tinyurl.com/yba2oteh (@Yoon_Seok_Kim)
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14:24 < streety> This article on vitamin D supplementation seems to be getting some press attention: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(18)30265-1/fulltext
14:24 < streety> focus is solely on fracture risk and mineral density though
14:35 < Phil> a lot of the current Vit D recs are based off of some shoddy research
14:36 < Phil> just not a very diverse set of people -- bunch of old white people in Wisconsin
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14:54 < streety> the press coverage of the meta-analysis seems to be pushing that supplementation is unnecessary
14:54 < streety> https://www.vox.com/2018/10/4/17933880/vitamin-d-health-sun-diet for example
15:05 < Phil> yeah, that's what it's pushing
15:06 < Phil> but it's only wrt those metrics, Vit D is a pretty important vitamin throughout the body
15:06 < Phil> so for those people with osteoporosis or at risk, or old people, don't waste your money on Vit D
15:06 < Phil> supps
15:35 < streety> Unless deficient. I haven't been through the meta-analysis but the cancer study also mentioned in the vox article had not great but decent levels at baseline
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16:43 < jrayhawk> Phil: oh yeah, i forgot to link you to https://www.ncbi.nlm.nih.gov/pubmed/23561234
16:43 < jrayhawk> check out that odds ratio
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17:01 < jrayhawk> and vitamin D research is also very messy because disease efficacy and toxicity is heavily dependent on retinol
17:01 < jrayhawk> which nobody seems to care about co-supplementing these days
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17:02 < kanzure> .title
17:02 < yoleaux> A prevalence study of urinary tract infections in acute relapse of schizophrenia. - PubMed - NCBI
17:03 < kanzure> .tw https://twitter.com/MarkFriedenbach/status/1049612214313857024
17:03 < yoleaux> @anderssandberg @kanzure That’s feasible. But the larger point is the loss of mass due to inflationary universe. That’s a loss of 100% of mass energy. (@MarkFriedenbach, in reply to tw:1049592029116796928)
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17:04 < jrayhawk> .title https://sci-hub.tw/10.1001/archotol.1941.00660040843010 you have to back a bajillion years to when people still had any curiosity about why cod liver oil reduced colds
17:04 < yoleaux> jrayhawk: Sorry, that command (.title) crashed.
17:05 < jrayhawk> .title https://www.ncbi.nlm.nih.gov/pubmed/19022954? there's some interesting mechanistic stuff here where it looks like A+D increase K1->mk4 conversion, which explains some of the improved calcium management
17:05 < yoleaux> 9-Cis retinoic acid reduces 1alpha,25-dihydroxycholecalciferol-induced renal calcification by altering vitamin K-dependent gamma-carboxylation of m... - PubMed - NCBI
17:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=dff9382a Michael Folkson: Add John Newbery Noded transcript >> http://diyhpl.us/diyhpluswiki/transcripts/noded-podcast/jnewbery-cve-2018-17144-bug/
17:05 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=208453ab Bryan Bishop: Merge pull request #17 from michaelfolkson/noded-john-newbery >> http://diyhpl.us/diyhpluswiki/
17:07 < jrayhawk> Do we know him around here? Or is he just some drive-by merge request?
17:07 < kanzure> drive-by merge request
17:07 < jrayhawk> huh, neat
17:07 < kanzure> from github
17:08 < kanzure> https://twitter.com/michaelfolkson/status/1049704777259597824
17:21 < streety> I was completely unaware of the synergism between A and D until earlier today. I knew about K but A does seem to be missed in discussion
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17:29 < kanzure> .title https://github.com/dalek-cryptography/bulletproofs/
17:29 < yoleaux> GitHub - dalek-cryptography/bulletproofs: A pure-Rust implementation of Bulletproofs using Ristretto.
17:32 < kanzure> https://medium.com/@wheatpond/its-probably-time-to-learn-chinese-63587376c2d2
17:41 < Phil> yeah, that's a wild OR...almost too wild lol
17:41 < kanzure> .title https://xbpeng.github.io/projects/SFV/index.html
17:41 < yoleaux> SFV: Reinforcement Learning of Physical Skills from Videos
17:42 < jrayhawk> .title https://www.ncbi.nlm.nih.gov/pubmed/24499998 Similar, but with an OR of merely 10
17:42 < yoleaux> jrayhawk: Sorry, that command (.title) crashed.
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18:29 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=64636483 Bryan Bishop: transcript: signmessage stuff >> http://diyhpl.us/diyhpluswiki/transcripts/scalingbitcoin/tokyo-2018/edgedevplusplus/wallet-security/
18:31 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=d0da5ae3 Bryan Bishop: tweeter link >> 
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--- Log closed Wed Oct 10 00:00:32 2018