--- Log opened Tue Feb 12 00:00:47 2019
00:14 < nmz787> .title https://elifesciences.org/articles/20985
00:14 < yoleaux> CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory | eLife
00:20 < nmz787> people speculating CRISPR HIV babies could have been an intelligence-enhancement test https://biohackinfo.com/news-crispr-twins-ccr5-intelligence-enhancement/
00:21 < nmz787> kanzure: maybe add that to your CCR5 section on gene mods?
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00:52 < fenn> https://biohackinfo.com/news-designer-babies-bitcoin-business/ journalism telephone game
00:53 < fenn> run it through google translate a few times while you're at it
00:55 < fenn> "already has an initial parent-couple costumer"
00:55 < fenn> they must be furries
00:56 < fenn> obviously genetically engineered catgirls are the killer app
00:59 < nmz787> I've been known to dress up in costumes
01:01 < nmz787> srsly I think we just need to start GMOing smarter, smaller, and more articulate elephants
01:01 < nmz787> combine that with some pig DNA
01:01 < nmz787> add a few extra asses
01:01 < fenn> now you're thinkin with your ass
01:02 < nmz787> http://wiki.southpark.cc.com/wiki/Four-Assed_Monkey
01:02 < nmz787> we already know what happens when you try messing with humans
01:02 < nmz787> "me bad?? baba chomp, ba chewy chomp"
01:03 < nmz787> "Oh my God! He only has one ass. He's of no use to me, I'll have to burn the room."
01:03 < fenn> "During a class discussion on genetic engineering, Kyle hits upon the idea of combining an elephant with a pig. He already owns an elephant (which he got via mail order) and Cartman has a potbellied pig named Fluffy. A classmate named Terrance (no relation to Terrance and Phillip) bets he can clone an entire human being before Kyle can produce his elephant/pig. The race is on."
01:04 < nmz787> "All I ever wanted was to genetically engineer something useful, but I failed. Perhaps we shouldn't be toying with God's creations. Perhaps we should just leave nature alone, to its simple one-assed schematics. "
01:06 < nmz787> http://wiki.southpark.cc.com/wiki/Dr._Alphonse_Mephesto#Creations
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01:11 < fenn> oddly enough four-assed man-bear-pigs already exist? https://www.aboutanimals.com/images/mandrill-alpha-male-walking-820x619.jpg
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03:51 < adlai> which sounds more ridiculous as a two-hour weekly introductory course: neuroscience, or stem cells?
03:52 < adlai> they are offered back-to-back, so i might just register for one and stick around for both
03:54 < adlai> the easy answer is that i should register for the chronologically earlier one, so that i don't ~have~ to stick around until after sunset
03:54 < adlai> incidentally, the stem cells course is chronologically earlier. this appeals to my sense of scheduling aesthetics.
04:02 < TMA> adlai: do you need further feedback, or was the rubberducking sufficient?
04:02 < adlai> the rubber-ducking sufficed
04:03 < adlai> i played "registration roulette": registered for one, then repeatedly tried to cancel the current registration and register for the other, until the registration period ended
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04:50 < kanzure> oh that old twitter reference is good ( https://twitter.com/kanzure/status/955178560133746690 ), helps show that antonio was wrong about the project being a secret
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09:41 < kanzure> hank greely hosting something at stanford feb14 https://law.stanford.edu/event/crisprd-babies-what-is-to-be-done/
09:41 < nmz787> on valentines day
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12:57 < kanzure> https://medium.com/indiebio-sf/the-100-trillion-opportunity-3d827f18c56a
12:59 < kanzure> https://biohackinfo.com/news-crispr-twins-ccr5-intelligence-enhancement/
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13:13 < kanzure> .tw https://twitter.com/biohackinfo/status/1094707227141713920
13:13 < yoleaux> What if Dr. He Jiankui actually wanted to enhance memory, learning and neuroplasticity in the #CRISPRbabies? Knocking out CCR5 can do other stuff... https://biohackinfo.com/news-crispr-twins-ccr5-intelligence-enhancement/ (@biohackinfo)
13:42 < archels> fresh dumpster dive, what should I do with it? http://itfromb.it/temp/gamma_monitor.jpg
13:42 < gwillen> does anybody here have experience with a company called Health Nucleus
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14:49 < fenn> looks like health nucleus is a genome sequencing and MRI "spa"
14:50 < fenn> "This is not a diagnostic disease testing platform."
14:52 < fenn> it sounds like they're intentionally going on an anomaly hunt, which iirc is considered bad in mainstream medicine because you dig up all sorts of stuff that turns out not to be a problem, but looks bad enough when you see it that you have to do a lot of tests to determine that it's not bad
14:54 < fenn> of course this is the same mainstream medicine that won't let you look at your own genome sequence
14:55 < fenn> i never understood this whole "don't tell me if i am genetically at risk for alzheimers" thing
14:57 < fenn> for much less than $25k (health nucleus' price) you can get a doctor to look at your genome sequence
15:01 < fenn> possibly it is $7500 for a bare bones service
15:03 < fenn> "Sean Parker calls China’s gene-edited babies ‘Sputnik 2.0,’"
15:04 < fenn> "He is famous for his founding roles at Facebook and Napster, but these days the billionaire philanthropist Sean Parker is turning his attention to fighting cancer. Three years ago, he announced a $250 million investment to build teams of scientists for immunotherapy research, one of the hottest fields in taking on cancer.
15:04 < fenn> Parker spoke intensely about his belief that the government needs to move far more aggressively in investing in biotech, life sciences, and health care. He returned repeatedly to the subject of job creation in those fields. And he said it was urgent that China not eclipse the United States in scientific innovation."
15:42 < jrayhawk> job creation in healthcare? what the hell
15:43 < jrayhawk> "I see we've mistaken motion for progress. I propose we add MORE MOTION."
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16:04 < adlai> if you optimize for kinetic energy without discounting potential energy, you're gonna have a bad spacetime
16:14 < fenn> politicians love them some jobs
16:14 < fenn> jerbs
16:14 < fenn> if you can harness that to do some good, instead of whatever other ridiculous crap they would have spent it on, then that's a win
16:15 < fenn> parker's cancer treatment strategy has a hope of actually curing cancer, unlike most therapies
16:17 < fenn> chimeric antigen receptor t-cells
16:17 < fenn> and other related stuff to make sure it works
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19:02 < kanzure> jrayhawk: the trick is to travel without moving at all
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19:28 < kanzure> .tw https://mobile.twitter.com/appelbap/status/1095288873255661571
19:28 < yoleaux> Selecting smarter embryos based on polygenic scores for IQ is looming. My colleagues Erik Parens and @WendyKChung and I share our thoughts on the ethical problems and the need for regulation: https://www.statnews.com/2019/02/12/embryo-profiling-iq-almost-here/ via @statnews (@appelbap)
19:28 < kanzure> .title https://www.statnews.com/2019/02/12/embryo-profiling-iq-almost-here/
19:28 < yoleaux> Profiling embryos to choose those with higher IQs is almost a reality - STAT
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19:31 < kanzure> .tw https://twitter.com/sudogene/status/1095525613904031744
19:31 < yoleaux> @kanzure Have you ever examined the linkage disequilibrium distribution-adjusted distribution of betas for any polygenic trait? (@sudogene, in reply to tw:1095525388757991424)
19:33 < kanzure> .tw https://twitter.com/kanzure/status/1095526036664659968
19:33 < yoleaux> @sudogene I think "polygenic traits" is an overrated way of thinking about this. Maybe I'm revealing too much, though. Keep in mind, I am firmly in the genetic engineering camp. (@kanzure, in reply to tw:1095525613904031744)
19:37 < nmz787> so they aren't gonna offer high IQ selection, but they'll allow low-IQ to be discluded... so parents just need a really high threshold for low
19:38 < kanzure> .tw https://twitter.com/sudogene/status/1095526685594828805
19:38 < yoleaux> @kanzure Most traits that have been examined end up being *more* polygenic than people expected from kindred studies. Being less rhetorical, the variants with the largest effect size (in traits that I'm familiar with) nevertheless contribute a nearly trivial proportion of genomic effect. (@sudogene, in reply to tw:1095526036664659968)
19:42 < kanzure> .tw https://twitter.com/kanzure/status/1095528103873597441
19:42 < yoleaux> @sudogene Yes, that's true. However, I think finding and editing the 500 polygenic loci related to IQ (or height, etc) is a red herring. It could work, but it's like trying to jumpstart an airline industry by ducktaping a thousand birds together. (@kanzure, in reply to tw:1095526685594828805)
19:43 < nmz787> lol
19:45 < nmz787> quack quack -- "why is this plane making duckhunt noises"
19:57 < kanzure> disregard the quacking
20:00 < superkuh> Almost relevant: http://superkuh.com/pictures/plif/wc107.gif
20:01 < kanzure> honk honk
20:02 < kanzure> yeah there's a really weird fasicnation with polygenic trait hunting
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20:49 < nmz787> that statnews article is really dumb
20:50 < nmz787> 'diametrically opposite directions' 'shape their children'  'accept their children as they are'
20:50 < nmz787> like, how the hell are those opposite in any way???
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--- Log closed Wed Feb 13 00:00:48 2019