--- Log opened Tue Feb 19 00:00:53 2019
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01:33 < superkuh> http://www.overcomingbias.com/2019/02/aliens-need-not-wait-to-be-active.html
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07:18 < kanzure> "Comment on 'The aestivation hypothesis for resolving Fermi's paradox'" https://arxiv.org/abs/1902.06730
07:45 < kanzure> .tw https://twitter.com/LauraDeming/status/1097644139968000000
07:45 < kanzure> yoleaux!
07:45 < kanzure> "Are there any people who are conversant in most of the genes in the human genome? i.e. learning a new language is ~20k words, there are 20k+ genes to have some knowledge of"
07:47 < kanzure> "Transposon-mediated, cell type-specific transcription factor recording in the mouse brain" https://www.biorxiv.org/content/10.1101/538504v1
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08:33 < kanzure> https://www.bsidesinterviews.com/josiahzayner
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08:34 < kanzure> indiebio class 8 started yesterday
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08:44 < nmz787> dentist: portable cleanroom
08:45 < nmz787> kanzure: fume hoods are for dirty things, generally
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09:18 < kanzure> http://bitcoin.sipa.be/miniscript/miniscript.html
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10:16 < kanzure> "significantly associated with personality traits in a meta-analysis of genome-wide association studies (N=123,132–260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2."
10:16 < kanzure> "conscientiousness with an intronic variant in KATNAL2" although the association isn't particularly strong anyway
10:17 < kanzure> "KATNAL2: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays."
10:26 < archels> https://www.aicrowd.com/challenges/unity-obstacle-tower-challenge
10:27 < archels> lots of prize money to be had
10:58 < kanzure> "A dopaminergic gene cluster in the prefrontal cortex predicts performance indicative of general intelligence in genetically heterogeneous mice" https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014036
10:58 < kanzure> "... identified a small number (<20) of genes that were differentially expressed across animals that exhibited fast and slow aggregate learning abilities. Of these genes, one functional cluster was identified, and this cluster (Darpp-32, Drd1a, and Rgs9) is an established modulator of dopamine signaling. Subsequent quantitative PCR found that expression of these dopaminegic genes plus one ...
10:58 < kanzure> ...vascular gene (Nudt6) were significantly correlated with individual animal's general cognitive performance. These results indicate that D1-mediated dopamine signaling in the PFC, possibly through its modulation of working memory, is predictive of general cognitive abilities. Furthermore, these results provide the first direct evidence of specific molecular pathways that might potentially ...
10:59 < kanzure> ...regulate general intelligence."
10:59 < kanzure> yeah i mean it might be as simple as make a dopamine receptor that has better binding efficiency
10:59 < kanzure> it would be interesting to do comparative analysis of dopamine receptor binding efficiency across the animal kingdom
11:06 < kanzure> "Dopamine D1 sensitivity in the prefrontal cortex predicts general cognitive abilities and is modulated by working memory training" http://learnmem.cshlp.org/content/20/11/617.full.pdf
11:06 < kanzure> "... These results suggest that the sensitivity (but not density) of D1Rs in the prelimbic cortex may both regulate general cognitive ability and be a target for working memory training."
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13:24 < kanzure> "Intra-cortical myelin mediates personality differences" https://onlinelibrary.wiley.com/doi/pdf/10.1111/jopy.12442
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13:31 < kanzure> "How thalamic relays might orchestrate supervised deep training and symbolic computation in the brain" https://www.biorxiv.org/content/biorxiv/early/2018/04/22/304980.full.pdf
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15:10 < kanzure> "Efficiency of weak brain connections support general cognitive functioning" http://www.tmslab.org/publications/700.pdf
16:12 < kanzure> "The strength of weak connections in the macaque cortico-cortical network" https://www.researchgate.net/profile/Alexandros_Goulas/publication/264047477_The_strength_of_weak_connections_in_the_macaque_cortico-cortical_network/links/553a2a720cf29b5ee4b452da/The-strength-of-weak-connections-in-the-macaque-cortico-cortical-network.pdf
16:17 < kanzure> uh.. nevermind.
16:33 < kanzure> "Comprehensive computational modelling of the development of mammalian cortical connectivity underlying an architectonic type principle" https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006550
16:40 < kanzure> "A null model of the mouse whole-neocortex micro-connectome" https://www.biorxiv.org/content/10.1101/548735v1.abstract
16:41 < kanzure> oh it's markram
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18:20 < kanzure> "Origins of the brain networks for advanced mathematics in expert mathematicians" https://www.pnas.org/content/pnas/113/18/4909.full.pdf
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19:22 < kanzure> "The role of the insula in intuitive expert bug detection in computer code: an fMRI study" https://link.springer.com/article/10.1007/s11682-018-9885-1
19:40 < kanzure> "Shared understanding of narratives is correlated with shared neural responses" https://www.sciencedirect.com/science/article/pii/S1053811918307948 (similar to the film/fMRI study)
19:55 < kanzure> "Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats" https://www.nature.com/articles/nbt1198_1040
19:56 < kanzure> and this... works?
19:57 < Jenda`> https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188453 "Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments"
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20:02 < kanzure> it doesn't seem to talk about the behavior of the neural chimeras
20:02 < kanzure> isn't that.. noteworthy?
20:03 < kanzure> gosh you think mice with chimeric brains behaving normally or differently would be notable in our article.... nah.
20:10 < kanzure> ah, here's a behavior study https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/stem.2971
20:22 < kanzure> "One study that deserves special attention transplanted fetalderived glial precursors into neonatal immunodeficient mice and found human glia throughout the entire brain within 12–20 months and was organized in a laminar structure, a phenotype previously thought to be present only in humans and nonhuman primates [136]. The human astrocytes maintained a human astrocyte morphology (i.e., ...
20:22 < kanzure> ...larger nuclei, long projections) within the mouse brain."
20:22 < kanzure> "Functionally, human astrocytes propagated calcium waves significantly faster than mouse astrocytes resulting in enhanced rates of field excitatory postsynaptic potentials and long-term potentiation. Behaviorally, chimeric mice displayed an improvement in the speed of acquisition of an auditory fear conditioning response, reduced latency to escape the Barnes maze, and an increase in the ...
20:22 < kanzure> ...ability of mice to remember the locations of objects in the object-location memory task, relative to wild-type mice. It is likely that the enhanced ability to learn in the human/mouse astrocyte chimeras is a result of subtle differences between the functions of human and mouse astrocytes rather than human astrocytes forming novel neuronal pathways. However, the enhanced ability of these ...
20:22 < kanzure> ...human/mouse chimeras to learn, regardless of whether the neuronal architecture is altered, is an important observation that necessitates further research."
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20:57 < kanzure> list of current NIH moratoriums https://www.niehs.nih.gov/research/resources/bioethics/timeline/index.cfm
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22:25 < fenn> blah why did i read all that
22:25 < fenn> oddly, it didn't say anything about the asilomar genetic engineering moratorium
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--- Log closed Wed Feb 20 00:00:54 2019