--- Log opened Sat Apr 13 00:00:43 2019
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08:09 < kanzure> .tw https://twitter.com/ESYudkowsky/status/1114667633821999104
08:09 < yoleaux> I've written enough words that Gwern could create a GPT-2-small of me and, at least from my perspective, it is the creepiest thing ever. I shudder to imagine what the GPT-2-large version will be like. And once they get fewer-shot learning down, the GPTs are coming for YOU. https://twitter.com/gwern/status/1112348601416630272 (@ESYudkowsky)
08:09 < kanzure> https://uploadedyudkowsky.tumblr.com/
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08:13 < kanzure> .tw https://twitter.com/MicroSnaps/status/1113204015804952576
08:13 < yoleaux> Dye-injected Purkinje cells in mouse cerebellum! 🔎20x (objective lens magnification) 🔬Confocal 📷Benjamin Barti #science #microscopy #microscope #CellBiology #neurobiology #mouse https://pbs.twimg.com/media/D3LlJSoWkAA_vBy.jpg (@MicroSnaps)
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08:15 < kanzure> .title https://www.youtube.com/watch?v=qsYrhHARD6g
08:15 < yoleaux> BPF Neuroscience Journal Club on El-Boustani et al. 2018 - YouTube
08:16 < kanzure> .title https://www.youtube.com/watch?v=jy6v_y0rj34
08:16 < yoleaux> BPF Video Series Episode 5 of 8 – Long-Term Arguments - YouTube
08:21 < kanzure> .title https://www.youtube.com/watch?v=GgzRdQ5nm0U
08:21 < yoleaux> Konrad Kording - Why neuroscience needs deep learning theory - YouTube
08:24 < kanzure> .tw https://twitter.com/robinhanson/status/1110889692906614790
08:24 < yoleaux> "Terrestrial organisms stuck on the outside of the International Space Station have survived 533 days in the vacuum, intense ultraviolet radiation, & extreme temperature variations of space. … That means it's not impossible for life to survive on Mars." https://www.sciencealert.com/a-bunch-of-earth-organisms-were-stuck-outside-the-iss-and-survived (@robinhanson)
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11:35 < nsh> wat's GPT-2-blah?
11:40 < kanzure> machine learning magic from openai group
11:40 < kanzure> "Efficient allelic drive in Drosophila" https://www.nature.com/articles/s41467-019-09694-w
11:41 < kanzure> https://japantoday.com/category/national/japan-eyes-law-to-tighten-control-on-gene-editing-of-human-eggs
12:01 < nsh> ah, ty
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13:50 < estill01> Howdy all. Anyone do organ engineering? / I built a bio-reactor that grows vasculature into co-cultures. Intention is to build out a broader platform for growing large-scale tissue systems/organs.
13:52 < estill01> Also have an interest / have done work on a semi-invasive BCI system. Have more work to do but with some focused effort (and resource) ought to make something pretty awesome.
13:53 < estill01> Lmk if either of these projects are of-interest. Both quite buildable with existing tech/known science.
13:56 < estill01> Currently working on getting organized a bit better to help streamline these projects / get them real/built-out. Very much a believer in building the future.
13:57 < estill01> Personal immediate-term target goal is cognitive longevity.
13:58 < estill01> Best way I can think of to achieve that - though admittedly a bit 'rough' / v.1.0 - is to grow brains and 'plug into' them.
14:00 < estill01> Ideally would 'plug in' with a mobile interface (thus the BCI project), though most immediate known-workable solution is to grow neuron tissue 'cables' and biologically integrate (thus the vascularization bio-reactor project).
14:00 < estill01> Happy to discuss further.
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14:10 < kanzure> estill01: you might have to wait a while. irc is async .
14:11 < kanzure> estill01: what organs have you vascularized in culture
14:14 < estill01> Did stem-cell derived optic cups / proto-eyes, though that was just due to availability.
14:16 < kanzure> estill01: any thoughts about doing something like http://diyhpl.us/~bryan/papers2/bio/in-vitro-fertilization/Efficient%20generation%20of%20functional%20haploid%20spermatids%20from%20human%20germline%20stem%20cells%20by%20three-dimensional-induced%20system%20-%202018.pdf
14:16 < estill01> Turns out though that generating organoids is actually fairly straightforward and there are known protocols for all/almost all organ systems
14:19 < estill01> kanzure: super interesting
14:19 < estill01> kanzure: my system is 3D as well
14:20 < estill01> kanzure: ... looking to see what their culturing system actually was
14:27 < estill01> kanzure: looks like a very standard/reasonable culturing protocol
14:27 < estill01> kanzure: the specifics though in the 'Reconstitution of testicular cells in matrigel matrix' section of the protocol are what you would expect tailored to the cell type
14:28 < estill01> kanzure: I did a similar tailoring but to promote vasculature development, e.g. spiked the system with VEGF
14:29 < estill01> kanzure: also integrated a peristaltic pump / system was a model circulatory system, not done in a welled plate.
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15:03 < fenn> "The hope is that each individual human being will rationalize their intelligence, invent new evidence that is superior to our own, and convince themselves that they can only do so much."
15:03 < fenn> i am starting to like robo-yudkowsky
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15:12 < fenn> "Belief in the Dark Side has always been a controversial topic. Some ethicists thought that belief in the Dark Side was a rationalist’s work - rather than a true duty to obey - but I don’t think that was the word “rational”, or even “moral”. I don’t think that the moral obligation to believe that the Dark Side is likely to happen is an obligation of rationality - or even a duty of
15:12 < fenn> responsibility"
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18:40 < kanzure> fenn: perhaps you should run a steve version
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18:51 < kanzure> "Optogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth" https://science.sciencemag.org/content/363/6434/1456
18:52 < kanzure> "Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution" https://science.sciencemag.org/content/363/6434/1463
18:52 < superkuh> We can make them better, faster, stronger, digestier than before.
18:53 < kanzure> "Biomolecular contrast agents for optical coherence tomography" https://www.biorxiv.org/content/10.1101/595157v1 https://twitter.com/mikhailshapiro/status/1112727765973790721
18:53 < kanzure> "Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function" https://www.nature.com/articles/s41467-019-09557-4 https://twitter.com/AlikWidge/status/1113783721956605953
18:54 < kanzure> "A truly injectable neural stimulation electrode made from an in-body curing polymer/metal composite" https://www.biorxiv.org/content/10.1101/584995v4 https://twitter.com/KipLudwig/status/1113967657894776833
18:55 < kanzure> "... an electrode liquid in a syringe that cures in body once injected around complex neural structures" i guess this is different from the recent sewing wire thing (stiff needle, inject looped thread into brain, remove stiff injector)
19:31 < fenn> sounds like the opposite of what you'd want; curing makes it more stiff and that causes cell death
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--- Log closed Sun Apr 14 00:00:44 2019