--- Log opened Sun Apr 14 00:00:44 2019
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02:23 < TMA> is anyone here able to prepare peroral pollen vaccine substitute?
02:25 < TMA> and if so would he/she/it be willing to share the know-how?
02:29 < TMA> I gather that making a pollen suspension in some diluent might not be entirely sufficient
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05:57 < kanzure> "DIY CRISPR" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3365421 (pro-regulation article)
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06:55 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=eb84712e Michael Folkson: Add Conner transcript on watchtowers >> 
06:55 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=e846cb49 Bryan Bishop: Merge pull request #36 from michaelfolkson/add-conner-watchtowers >> http://diyhpl.us/diyhpluswiki/
07:01 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=feb79b17 Bryan Bishop: tweeter link >> http://diyhpl.us/diyhpluswiki/transcripts/boltathon/2019-04-06-conner-fromknecht-watchtowers/
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07:11 < kanzure> wiki/transcripts/ is now 1.5m words (10 MB)
07:13 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=08973e46 Bryan Bishop: add a discussion follow-up link >> http://diyhpl.us/diyhpluswiki/transcripts/boltathon/2019-04-06-conner-fromknecht-watchtowers/
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07:24 < kanzure> .tw https://twitter.com/HankGreelyLSJU/status/1116846591770529793
07:25 < yoleaux> I agree entirely w/@pknoepfler that it’s nowhere close to proven safe OR effective and that must be required. But if/when it is, I can’t see a decent justification for stopping those couples. That there may only be a few k of them is not a good excuse. I think. https://twitter.com/pknoepfler/status/1116843079330193409 (@HankGreelyLSJU)
07:25 < kanzure> .tw https://twitter.com/GovindPersad/status/1116887653574561792
07:25 < yoleaux> @pknoepfler @HankGreelyLSJU I have been thinking, in violation of rule to focus on 1 thing pretenure, about how US law would evaluate proposals like @pknoepfler's (& also calls for social consensus). If procreation is a fundamental right, then doubtful we can limit access in order to prevent enhancement (@GovindPersad, in reply to tw:1116863465363165184)
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13:32 < kanzure> https://qualiacomputing.com/2019/04/11/every-child-is-a-genetic-experiment-faah-clinical-trials-for-hedonic-recalibration-as-educated-guesses-rather-than-reckless-experimentation/
13:33 < kanzure> "mutations in both the FAAH gene and its newly-discovered sister gene, FAAH-OUT, which modulates the FAAH gene"
13:34 < kanzure> "The pain-modulating SCN9A gene, which has dozens of alleles conferring varying pain (in)tolerance, is much better studied"
13:34 < kanzure> https://www.wired.com/story/crispr-gene-editing-could-one-day-cut-away-human-pain/
13:35 < kanzure> "Yet all babies born today are unique and untested genetic experiments. All baby-making entails creating involuntary suffering. None of our genetic experiments first passed muster with a medical ethics committee. Any proposal to create transhuman superbabies will probably strike our descendants as genetic remediation, not enhancement. If we reject the arguments of anti-natalists, who view ...
13:35 < kanzure> ...Darwinian life as malware, then all prospective parents are committed to practising genetic experimentation – just not under that inflammatory label. So what’s at issue is not the principle of genetic innovation, only whether we should harness the new tools of CRISPR-Cas9 genome-editing to conduct our experiments more responsibly. If aspiring writers can benefit from proofreaders and ...
13:35 < kanzure> ...editors, why not aspiring parents too – where the stakes are higher?"
13:37 < kanzure> "Generation of viral vectors specific to neuronal subtypes of targeted brain regions by Enhancer-Driven Gene Expression (EDGE)" https://www.biorxiv.org/content/10.1101/606467v1.supplementary-material
13:38 < kanzure> "Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848893/
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14:43 < nmz787> maybe I should just start telling people we genetically engineered our kid
14:52 < kanzure> "Introducing a spectrum of long-range genomic deletions in human embryonic stem cells using type I CRISPR-Cas3" https://www.sciencedirect.com/science/article/abs/pii/S1097276519302175
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21:57 < periffis> How does this factor into shit like "flow?" https://www.ninds.nih.gov/News-Events/News-and-Press-Releases/Press-Releases/Want-learn-new-skill-Take-some-short-breaks
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--- Log closed Mon Apr 15 00:00:45 2019