--- Log opened Tue Apr 23 00:00:52 2019
00:07 < adlai> what's a Doudna and why is it playing tetradimensional chess against the Neo&Bee scammer?
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01:01 < nmz787> adlai: .wik Jennifer Doudna
01:01 < nmz787> .wik Jennifer Doudna
01:01 < yoleaux> "Jennifer Anne Doudna, PhD (born February 19, 1964) is an American biochemist. She is a Li Ka Shing Chancellor Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology at the University of California, Berkeley." — https://en.wikipedia.org/wiki/Jennifer_Doudna
01:15 < adlai> how many crisps does it take to make a baby crispr?
01:16  * adlai asked a question answerable within the patent's unwritten assumptions, most likely.
01:35 < archels> wow, I cannot click old links to papers from my Frontiers newsletter?
01:35 < archels> links of the type http://click.engage.frontiersin.com/?qs=62b22d545de33fe7f9f788f087e46ccd3684ca2c2ce8e3a6143c3ec067c0aa7d0b4a7a9b59af5ad345591a2788ddfe80b01b403f5e6ecdf31072284c8d2e1487
01:35 < archels> "This link has expired. Please contact the sender of the email for more information."
01:47 < nmz787> http://www.faims.com/what.htm
01:47 < nmz787> .title
01:47 < yoleaux> FAIMS
01:47 < nmz787> " WHAT is High-Field Asymmetric Waveform Ion Mobility Spectrometry? "
01:47 < nmz787> "FAIMS is a new technology capable of separation of gas-phase ions at atmospheric pressure (760 torr) and at room temperature. FAIMS can be operated over a wide range of pressures and has been tested above 1500 torr. FAIMS will operate at lower and higher temperatures. "
01:55 < adlai> archels: frontiers of whatexactly, the honeycomb correspondence labyrinth?
01:57 < adlai> how's FAIMS different from decomposing the casimir effect across a basis spanning the isospin crystals ?
02:00 < nmz787> https://www.eevblog.com/forum/projects/has-anybody-built-their-own-mass-spectrometer-before/
02:00 < nmz787> re RF quadrupole machining "Cylinders are traditional, because centerless grinding is a manufacturing process capable of astonishingly regular roundness and straightness."
02:00 < nmz787> .wik centerless grinding
02:00 < yoleaux> "Centerless grinding is a machining process that uses abrasive cutting to remove material from a workpiece. Centerless grinding differs from centered grinding operations in that no spindle or fixture is used to locate and secure the workpiece; the workpiece is secured between two rotary grinding wheels, and the speed of their rotation  …" — https://en.wikipedia.org/wiki/Centerless_grinding
02:01 < nmz787> adlai: no idea, you tell me
02:03 < adlai> my guess is that the first-principles intuition breaks down once the numerical effect of increased distance grows to contain a distinction between separable ions, and those which are not removable from the instrument.
02:07  * adlai assumed, without proof, that an apparatus measuring the Casimir effect can not distinguish being placed within a sufficiently-smooth electric field.
02:08 < adlai> these things stop working when random multipoles go pffwhzzt in your circuitry.
02:11 < adlai> ah cool... http://www.faims.com/pub.htm this seems to be old demilitarized ideas deemed obvious enough for children to speculate about. cute!
02:12 < adlai> it's always fun to correlate flag burnings with the publication of flint-steel thermochemistry
02:12 < fenn> this is standard analytical chemistry. nothing military about it
02:15 < adlai> lots of folks just don't appreciate an efficient isotope distillery!
03:37 < adlai> would it be bad form to consider the ergo-landscape of isospin crystals (eg, the topology induced by labelling the clique spanning a lone proton, a lone neutron, a deuteron, and the two phase components of sublambda helium, as a starting corner) as a metrizable structure, from which to define a time-dependent functional?
03:38  * adlai keeps colliding against this trivialized "here are the nuclei, if you really must then you can locate them in closed loop orbits within R3 but THAT'S IT" barrier
03:40 < adlai> a barrier which, unless i am mistaken, does not prevent consideration of the nucleic locus as a vector of density functions.
03:40 < adlai> although it gives a terrific sense of false security and glib understanding.
04:01 < fenn> the positional uncertainty of the nucleus is many orders of magnitude smaller than the distance between electrodes in the instrument, so it can be considered a point
04:03 < fenn> you can try to conjure enough quantum woo to expect anything to happen, but it won't
04:03 < fenn> not until you build an infinite improbability drive
04:13 < adlai> actually, that's an idiotic expectation.
04:14 < adlai> and an even less logical conjuring attempt, which is why my interest in such a theory's topology stems from concerns regarding the efficiency of knowledge transferrance. ever tried teaching solid-state physics to an undergrad who barely understood vector calculus?
04:16 < adlai> one rapidly discovers that the "all lexicographically specifiable sets are sets" approach doesn't lead to concise statements of infinitesimals, in either direction.
04:26 < adlai> fenn: wouldn't a complete approach consider the trajectories to, from, and within the confinement space, and attack the interactions between field anisotropies and the isotope's parity violations?
04:27 < nsh> people are more often interested in working abstractions than a complete approach
04:28 < nsh> 'standard analytical chemistry' being a pretty erstwhile working abstraction
04:32 < fenn> let me know when you have a working complete approach
04:33  * adlai wonders whether isotopes targeted for separation by a certain field induce closed paths for isotopes with characteristic decay times longer than the expected usage life of an instrument
04:35 < adlai> fenn: regrettably, my time is wasted on innumerable topics other than the minimal spanning surface problem
04:37 < adlai> there are a handful of concise, cogent books, employing seemingly sensible notation. and an infinite holiday of ... noise, cancer, and other assorted distractions
04:38 < adlai> it truly makes one suspect that phenomena emerging from an implemented search, are provably-incapable of unimplementing it.
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07:48 < kanzure> .title https://www.nature.com/articles/d41586-019-01282-8
07:48 < yoleaux> Australian gene-editing rules adopt ‘middle ground’
07:49 < kanzure> "The Australian government will not regulate the use of gene-editing techniques in plants, animals and human cell lines that do not introduce new genetic material."
07:49 < kanzure> "The Australian regulator says that genetic edits made without templates are no different from changes that occur in nature, and therefore do not pose an additional risk to the environment and human health. Gene-editing technologies that do use a template, or that insert other genetic material into the cell, will continue to be regulated by the OGTR."
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08:23 < nsh> .title https://edgy.app/dual-core-computers-inside-human-cells
08:23 < yoleaux> Scientists Build Dual-Core Computers Inside Human Cells Using CRISPR
08:24 < nsh> -> https://www.pnas.org/content/116/15/7214
08:24 < nsh> .title
08:24 < yoleaux> A CRISPR/Cas9-based central processing unit to program complex logic computation in human cells | PNAS
08:54 < kanzure> you can also do regulatory circuits that do computation with recombinases
09:25 < nsh> cool
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11:48 < kanzure> "Validation of concurrent preimplantation genetic testing for polygenic and monogenic disorders, structural rearrangements, and whole and segmental chromosome aneuploidy with a single universal platform" https://www.sciencedirect.com/science/article/pii/S1769721219301016?via%3Dihub
11:51 < nmz787> go AUS
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16:22 < l_wl> Any update on mars inner temperatures
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19:13 < fenn> .title https://www.nature.com/articles/s41467-019-09730-9
19:13 < yoleaux> Colossal barocaloric effects near room temperature in plastic crystals of neopentylglycol | Nature Communications
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22:03 < fenn> .title http://arxiv.org/abs/1611.04135v1
22:03 < yoleaux> [1611.04135v1] Automated Inference on Criminality using Face Images
22:05 < fenn> normal people look similar, but criminals look different. i'd like to see how attractiveness overlaps these categories
22:08 < fenn> it's a very subtle effect
22:49 < kanzure> hi welcome to mountain view are you going to be over here
22:56 < fenn> not me. i'm on the night shift atm
22:58 < kanzure> but i need moral support?
22:59 < fenn> for what?
--- Log closed Wed Apr 24 00:00:53 2019