--- Log opened Tue Jun 04 00:00:31 2019
00:09 -!- purpleshift [purpleshif@gateway/vpn/mullvad/purpleshift] has quit [Quit: .]
00:12 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap
00:31 < fenn> for someone so high functioning, daniel tammet hasn't accomplished very much. a few moderately successful books and regular speaking invitations
00:32 < fenn> i would have expected some ramanujan level proofs by now
00:51 < kanzure> well you see he has to spend all of the brain power on justifying the massive ego
00:53 < darsie> Ramanujan wasn't very much into proofs, IIRC.
00:53 < Urchin> also, Ramanujan had it easy, there was a lot less discovered back then
00:53 < Urchin> and, yes, Ramanujan didn't write any proofs, at least in the beginning
00:53 < fenn> Urchin: seriously, have you seen the crazy stuff ramanujan came up with?
00:53 < fenn> nobody else would have discovered it
00:54  * darsie just saw the movie.
00:57 < Urchin> still, for physics at least, last solo grand scale theoretical work was in the '60s, and last solo Nobel Prize was in '80s (and that was essentially for using faulty microchips and stumbling onto a discovery)
01:02 < fenn> he doesn't have to work solo
01:36 -!- adamsky [~adamsky3@178235181168.unknown.vectranet.pl] has joined ##hplusroadmap
02:20 < fenn> .wik jack kilby
02:20 < yoleaux> "Jack St. Clair Kilby (November 8, 1923 – June 20, 2005) was an American electrical engineer who took part  (along with Robert Noyce) in the realization of the first integrated circuit while working at Texas Instruments (TI) in 1958. He was awarded the Nobel Prize in Physics on December 10, 2000." — https://en.wikipedia.org/wiki/Jack_Kilby
02:21 < fenn> they sure waited long enough
02:37 -!- adamsky [~adamsky3@178235181168.unknown.vectranet.pl] has quit [Remote host closed the connection]
02:37 -!- adamsky [~adamsky3@178235181168.unknown.vectranet.pl] has joined ##hplusroadmap
03:05 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Read error: Connection reset by peer]
03:36 -!- berndj [~berndj@azna.co.za] has quit [Ping timeout: 258 seconds]
05:18 < kanzure> "Who do you think are the most influential or action-oriented transhumanists on longevity or immortality right now? We have a special issue on longevity coming up and I am tasked with finding something interesting and/or fresh."
05:19 < kanzure> http://www.the-odin.com/bioe-101-pre-recorded
05:47 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-clveubiihwlljklu] has joined ##hplusroadmap
05:54 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8a7b2660 Andrew Poelstra: Typo fixes for 2019-05 noded podcast w Andrew Poelstra >> http://diyhpl.us/diyhpluswiki/transcripts/noded-podcast/2019-05-11-andrew-poelstra-miniscript/
05:54 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=8fc7b1d8 Bryan Bishop: Merge pull request #40 from apoelstra/patch-2 >> http://diyhpl.us/diyhpluswiki/
05:54 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=2292119d Bryan Bishop: add anti wisdom teeth, anti sunburn mitigation >> http://diyhpl.us/diyhpluswiki/genetic-modifications/
05:56 < fenn> irina conboy, ken hayworth, robert mcintyre, adam marblestone, caliban of longecity forums, greg fahy, cynthia kenyon, josh mitteldorf
05:57 < fenn> dunno if "interesting and fresh" but they're all doin stuff
06:06 < archels_> kanzure: who's asking?
06:09 < kanzure> journalist
06:12 < fenn> for a more sensationalist angle there was that guy injecting GDF-11 and publishing his blood tests
06:12 < fenn> haven't followed up for a few years tho
06:13 < kanzure> archels_: see pm
06:13 < kanzure> fenn: who do we know around amsterdam?
06:14 < fenn> http://diyhpl.us/~bryan/papers2/longevity/gdf11-steve-perry/
06:14 < kanzure> isn't this where the openwater people are supposed to be
06:15 < fenn> uhh.. blender foundation is there
06:15 < archels_> Waag DIYBio is in Amsterdam
06:15  * archels_ is about 30 mins away by train :)
06:15 < kanzure> archels_: let's meet up
06:16 < fenn> .nl is a big undifferentiated blob in my mind
06:16 < kanzure> archels_: a bunch of bitcoin core developers are probably going to dinner together this evening
06:17 < archels_> fenn: it's too small a country to be highly heterogeneous, but there are hotspots, like Eindhoven for tech
06:55 < fenn> well you can't really argue that the "cure" is bad, i mean these are all good things: https://joshmitteldorf.scienceblog.com/2018/10/14/a-cure-for-alzheimers-yes-a-cure-for-alzheimers/
06:58 < fenn> you'd think they could just inject the good peptide
07:00 -!- purpleshift [purpleshif@gateway/vpn/mullvad/purpleshift] has joined ##hplusroadmap
07:01 < fenn> you have to say "Optimize all metals" in the Dalek voice
07:23 < fenn> bredesen MEND protocol has a lot of familiar supplements: https://docs.wixstatic.com/ugd/1a2e49_a6311e25b2e844c2986b03143356f415.pdf
07:24 < fenn> (pg 5)
07:37 < jrayhawk> oh, that's much more heartening than i expected
07:37 < fenn> doctors seem to hate it
07:38 < fenn> well, they can fuck right off until they come back with a cure
07:39 < jrayhawk> normally when i read "alzheimers cure" it's some dumb superficial thing rather than actually dealing with the underlying metabolic syndrome
07:40 < fenn> i do wish he would pare it down a bit
07:44 < fenn> " nine of ten patients reportedly demonstrated “objective or subjective” improvement, and six were able to go back to work. That’s nice, but where are the results of the full dementia evaluations, complete with standardized cognitive assessment examinations before and after the MEND protocol intervention? This case series really needs some meat on its bones before it will persuade me"
07:44 < fenn> "Long on description, short on concrete reporting and controls."
07:45 < fenn> it's hard to believe that the director of the buck institute could only get 10 alzheimers patients, and doesn't know how to do proper controls
07:45 < fenn> or at least bisect your options
07:52 < fenn> "He received Federal funding (not to mention the affiliation with UCLA), which therefore means the study is covered by the Common Rule and requires IRB review and approval. No mention is made in the paper of any ethical review.
07:52 < fenn> What's worse, cognitively impaired individuals are considered vulnerable populations. 45 CFR 46 requires researchers and IRBs to include additional protections for the subjects.
07:52 < fenn> yep, better to just let them die without even trying. good job all around. ethics win!
07:54 < jrayhawk> when was the last time anyone included IRB review in their published paper
07:54 < jrayhawk> who are these people
07:54 < fenn> haters
07:54 < jrayhawk> they're just making up increasingly insane criticisms that make no sense
07:55 < fenn> a blog specifically about taking the piss out of "quackademics"
07:56 < fenn> i think they have a point in that it's bad science
07:56 < fenn> it's unfair to lump him into the same category as homeopathy and reiki
08:00 -!- yashgaroth [~ffffffff@2606:6000:ca81:3100:9018:9211:5c11:660b] has joined ##hplusroadmap
08:32 -!- yashgaroth_ [~ffffffff@2606:6000:ca81:3100:9018:9211:5c11:660b] has joined ##hplusroadmap
08:35 -!- yashgaroth [~ffffffff@2606:6000:ca81:3100:9018:9211:5c11:660b] has quit [Ping timeout: 248 seconds]
08:46 -!- adamsky [~adamsky3@178235181168.unknown.vectranet.pl] has quit [Remote host closed the connection]
09:14 -!- yashgaroth_ [~ffffffff@2606:6000:ca81:3100:9018:9211:5c11:660b] has quit [Read error: Connection reset by peer]
09:15 -!- yashgaroth_ [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has joined ##hplusroadmap
09:25 -!- yashgaroth_ [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has quit [Read error: Connection reset by peer]
09:26 -!- yashgaroth_ [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has joined ##hplusroadmap
09:40 -!- Mamuro7788 [~Mamuro878@60.54.37.178] has joined ##hplusroadmap
09:48 -!- Cory [Cory@unaffiliated/cory] has quit [Ping timeout: 248 seconds]
09:56 -!- Cory [Cory@unaffiliated/cory] has joined ##hplusroadmap
10:44 -!- yashgaroth_ [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has quit [Read error: Connection reset by peer]
10:44 -!- yashgaroth_ [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has joined ##hplusroadmap
11:01 -!- Mamuro7788 [~Mamuro878@60.54.37.178] has quit [Read error: Connection reset by peer]
11:08 -!- purpleshift [purpleshif@gateway/vpn/mullvad/purpleshift] has quit [Quit: .]
11:10 < nmz787_> jrayhawk: what do you think about this "anti wisdom teeth" gene edit? It seems stupid to me relative to just increasing the jaw size so all the teeth fit
11:10 -!- yash [~ffffffff@2606:6000:ca81:3100:9018:9211:5c11:660b] has joined ##hplusroadmap
11:11 -!- yash is now known as Guest69165
11:14 -!- Guest69165 [~ffffffff@2606:6000:ca81:3100:9018:9211:5c11:660b] has quit [Client Quit]
11:14 -!- yashgaroth_ [~ffffffff@cpe-76-176-31-235.san.res.rr.com] has quit [Ping timeout: 248 seconds]
11:16 < kanzure> https://www.martinvigo.com/voicemailcracker/
11:16 < kanzure> nmz787_: if you have a reliable way to get massive mandibles let me know
11:17 < nmz787_> I have a feeling jrayhawk will just say "chew more"
11:20 < nmz787_> .title https://www.nature.com/articles/s41467-018-07610-2
11:20 < yoleaux> A scalable peptide-GPCR language for engineering multicellular communication | Nature Communications
11:23 < nmz787_> .title https://www.ncbi.nlm.nih.gov/pubmed/12761335
11:23 < yoleaux> The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. - PubMed - NCBI
11:26 < nmz787_> .title https://www.fpbase.org/protein/zsgreen/
11:26 < yoleaux> ZsGreen :: Fluorescent Protein Database
11:27 < jrayhawk> retroagnathia also causes airway obstruction in both the nasal passages and the throat
11:27 < jrayhawk> so chew more
11:27 < jrayhawk> er, retrognathia
11:28 < nmz787_> .wik retrognathia
11:28 < yoleaux> "Retrognathia is a type of malocclusion which refers to an abnormal posterior positioning of the maxilla or mandible, particularly the mandible, relative to the facial skeleton and soft tissues." — https://en.wikipedia.org/wiki/Retrognathia
11:28 < jrayhawk> https://www.youtube.com/watch?v=e2ck0A5oKjU
11:28 < nmz787_> .title
11:28 < yoleaux> AHS16 - Kevin Boyd - Pre-and Post-natal Retrognathia - YouTube
11:28 < nmz787_> jrayhawk: so basically editing the wisdom teeth away will be a short lived branch of the genetic tree?
11:29 < jrayhawk> we're all a short-lived branch of the genetic tree
11:29 < nmz787_> my ancestors were all survivors
11:29 < jrayhawk> i am sure that will be very comforting when the AI megamind harvests your body for carbon
11:31 < nmz787_> no need for teeth or nasal passages or throats when we all have vitamix blenders and metal skull implants to keep the passages open
11:31 < jrayhawk> i, for one, look forward to the grim meathook future
11:31 < jrayhawk> it has "meat" right in the name, and i love meat!
11:32 < nmz787_> haha
11:42 -!- yashgaroth [~ffffffff@2606:6000:ca81:3100:84ea:1db6:c600:22e] has joined ##hplusroadmap
11:52 -!- Guest53917 [~chat264@196-209-221-45.dynamic.isadsl.co.za] has joined ##hplusroadmap
11:57 -!- Guest53917 is now known as berndj
12:02 -!- spaceangel [~spaceange@ip-89-176-92-23.net.upcbroadband.cz] has joined ##hplusroadmap
12:48 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap
13:15 -!- LeoTal [~Adium@140.170.86.79.rev.sfr.net] has quit [Ping timeout: 272 seconds]
13:41 -!- spaceangel [~spaceange@ip-89-176-92-23.net.upcbroadband.cz] has quit [Remote host closed the connection]
14:01 -!- Cory [Cory@unaffiliated/cory] has quit [Ping timeout: 272 seconds]
14:08 -!- Pasha [Cory@unaffiliated/cory] has joined ##hplusroadmap
14:10 -!- Pasha is now known as Cory
15:18 < jrayhawk> i should've made explicit: insofar as it's prudent to modify the mandible to avoid tooth and tongue crowding, it is also prudent to modify the upper palette
15:22 < jrayhawk> and the "short-lived branch" is, at this point, the default, as we are currently in the throes of a failure to do so; part of the endemic oxidative stress and inflammation we see is sleepnessness caused by airway-constricted sleep apnea.
17:15 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap
17:17 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 244 seconds]
17:18 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 246 seconds]
18:38 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-clveubiihwlljklu] has quit [Quit: Connection closed for inactivity]
19:30 < fenn> all that weston price stuff is phenotype due to environment, not due to genotype
20:29 -!- LeoTal [~Adium@97.170.86.79.rev.sfr.net] has joined ##hplusroadmap
20:31 -!- LeoTal1 [~Adium@116.170.86.79.rev.sfr.net] has joined ##hplusroadmap
20:33 -!- LeoTal [~Adium@97.170.86.79.rev.sfr.net] has quit [Ping timeout: 248 seconds]
21:24 -!- LeoTal1 [~Adium@116.170.86.79.rev.sfr.net] has quit [Read error: Connection reset by peer]
21:25 -!- LeoTal [~Adium@116.170.86.79.rev.sfr.net] has joined ##hplusroadmap
21:34 -!- yashgaroth [~ffffffff@2606:6000:ca81:3100:84ea:1db6:c600:22e] has quit [Quit: Leaving]
22:28 -!- LeoTal [~Adium@116.170.86.79.rev.sfr.net] has quit [Quit: Leaving.]
22:28 -!- LeoTal [~Adium@116.170.86.79.rev.sfr.net] has joined ##hplusroadmap
23:46 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection]
23:55 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap
--- Log closed Wed Jun 05 00:00:32 2019