--- Log opened Tue Sep 17 00:00:14 2019
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02:46 < nsh> who has a US university login/IP address and would like to dl a book for me?
02:46 < nsh> https://babel.hathitrust.org/cgi/wayf?target=https%3A%2F%2Fbabel.hathitrust.org%2Fcgi%2Fpt%3Fid%3Dmdp.39015028290875%3Bpage%3Droot%3Bseq%3D1%3Bview%3D1up%3Bsize%3D100%3Borient%3D0
02:46 < nsh> (libgen/scihub no use)
02:47 < nsh> i guess i could rip it page by page from babel.haithitrust but this is nicer
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02:59 < fenn> josiah zayner says: "For the past 6 months we have been doing lots of R&D to figure out how we could make human cell culture and engineering accessible. This means getting rid of everything
03:00 < fenn> normally used in labs like CO2 incubators, culture hoods and expensive media. We finally managed to consistently grow and engineer HEK 293 cells" and they're teaching a class on it
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03:00 < kanzure> neat.
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03:03 < kanzure> .tw https://twitter.com/41Strange/status/1171631591426146305
03:03 < EmmyNoether> Pulsing Umbilical Cord iPhone Charger by Japanese designer Mio Izawa https://video.twimg.com/tweet_video/EEJ4mP2UEAA6RrD.mp4 (@41Strange)
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03:09 < kanzure> looool https://academia.stackexchange.com/questions/25910/what-does-overhead-rate-mean
03:58 < kanzure> i missed a few organoid papers a few weeks ago. does anyone know which ones these were?
04:14 < kanzure> it was something about combining organoids together with each other, and vascularization, and larger organoids
04:14 < kanzure> "An in vivo model of functional and vascularized human brain organoids" https://www.nature.com/articles/nbt.4127
04:14 < kanzure> neat, but that's not it.
04:17 < kanzure> http://www.rdgao.com/oscillating-organoids/
04:18 < kanzure> "The main difference of the organoid protocol is that, instead of plating the iPSCs and waiting for them to form neural progenitor cells and then neurons, the iPSCs are maintained in suspension (via rotation) as stem cells. With the proper magic sauce (growth factors), the whole development process happens in this 3D form, where stem cells naturally clump together and the ones near the center ...
04:18 < kanzure> ...start to differentiate “naturally” and eventually migrate and form these “cortical column-like” structures. I say “naturally” because, obviously, we’re providing these growth factors that would be naturally produced in-embryo."
04:19 < kanzure> "Cell diversity and network dynamics in photosensitive human brain organoids" https://www.nature.com/articles/nature22047
04:28 < kanzure> "Individual brain organoids reproducibly form cell diversity of the human cerebral cortex" https://www.nature.com/articles/s41586-019-1289-x
04:29 < kanzure> "... Miller develops new biomaterials, 3D printing methodologies, and sacrificial casting strategies to enable the rapid fabrication of engineered tissues containing perfusable vascular architectures. Patterned vasculature facilitates capillary sprouting and supports the function of primary parenchymal cells in centimeter-sized constructs. Together these technologies provide a flexible ...
04:30 < kanzure> ...platform for a wide array of specific applications, and may enable the scaling of densely populated tissue constructs to arbitrary size." (jmil)
04:30 < kanzure> if vascularization is working, then why are these things limited to a few centimeters?
04:31 < kanzure> http://millerlab.rice.edu/research/
04:32 < kanzure> https://github.com/MillerLabFTW/OpenSourcePneumaticSystem
04:35 < kanzure> "Multivascular networks and functional intravascular topologies within biocompatible hydrogels" https://science.sciencemag.org/content/364/6439/458
05:01 < fenn> this actually looks halfway decent. probably costs too much ($100) https://industruino.com/
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06:07 < kanzure> "Genealogical correspondence of mushroom bodies across invertebrate phyla" https://www.cell.com/current-biology/fulltext/S0960-9822(14)01358-X
06:08 < kanzure> "Take for example the work of Nicholas Strausfeld, a neuro-anatomist at the University of Arizona in Tucson. He and others have found that the neural circuits underlying smell, episodic memory, spatial navigation, behaviour choice and vision in insects are nearly identical to those performing the same functions in mammals – despite the fact that different, though overlapping, sets of genes ...
06:08 < kanzure> ...were harnessed to build each one."
06:08 < kanzure> from https://aeon.co/essays/what-the-ctenophore-says-about-the-evolution-of-intelligence
06:31 < nsh> we assume the sensory faculties are organise from the inside out
06:31 < nsh> but perhaps they are organised from the outside in
06:32 < nsh> and a photonic gestalt perceptive faculty will tend to be similar to another photonic gestalt perceptive faculty by virtue of the phontic gestalt to be perceived being the same or similar
06:32 < nsh> almost independently of the lego brick factory that helps create one
06:32 < nsh> or more generally, genes aren't magical you stupid stupid people
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06:32 < nsh> they just make bits that complex environmental interactions make into more interesting bits
06:33 < nsh> everyone needs to get their head out of the arse of the DNA molecule for five seconds
06:33 < nsh> and take a few deep breaths
06:33 < nsh> ears look like ears because noises grow earlike things
06:33 < nsh> and eyes look like eyes because visions grow eyelike things
06:34 < nsh> obviously this is a gross caricature but it's no less silly than the converse
06:34 < nsh> that pure nucleotide codes prefigure eyes and ears and everything in between
06:35 < fenn> thank you, professor nsh
06:41 < nsh> pardon my grossly informed and useless fist-shaking at clouds
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10:13 < kanzure> .tw https://twitter.com/AdamHantman/status/1173920227010236417
10:13 < EmmyNoether> @GordFishell we need a retrograde AAV that works well in thalamus and then i think we can do a lot. Working on it right now. (@AdamHantman, in reply to tw:1173919879717519360)
10:15 < kanzure> "Explicit memory creation during sleep demonstrates a causal role of place cells in navigation" https://www.nature.com/articles/nn.3970
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10:29 < superkuh> Neat. So they stuck some electrodes in CA1, let 'em roam, identified the arbitrary place cell their electrodes happened to be by, then when that cell fired in slow wave sleep they triggered stimulation around the axons between the nucleus accumbens and ventral tegmental area. Then when the mice work up they spent more time in the area where the arbitrary place cell fired at.
10:29 < superkuh> woke up, rather.
10:30 < superkuh> Now do I stick this one in /Sleep or /Hippocampal Formation ... the problems of folders vs. tags.
10:57 < nsh> hm
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13:33 < nmz787> kanzure: that charge cable is straight out of existenz
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14:58 < kanzure> "Extremely stretchable and self-healing conductor based on thermoplastic elastomer for all-three-dimensional printed triboelectric nanogenerator" https://www.nature.com/articles/s41467-019-10061-y
14:59 < kanzure> how hard would this be to make these kind of conductors
15:03 < nsh> .wik triboelectric nanogenerators
15:03 < EmmyNoether> TypeError: argument of type 'NoneType' is not iterable (wik:33)
15:04 < nsh> .wik Triboelectric effect
15:04 < EmmyNoether> TypeError: argument of type 'NoneType' is not iterable (wik:33)
15:04  * nsh frowns
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15:18 < nsh> .wik triboelectric nanogenerator
15:18 < EmmyNoether> "A Nanogenerator is a type of technology that converts mechanical/thermal energy as produced by small-scale physical change into electricity." - https://en.wikipedia.org/wiki/Nanogenerator
15:18 < nsh> really it should copy from the subheading if that is a closer match
15:18 < nsh> but meh
15:19 < nsh> e.g. https://en.wikipedia.org/wiki/Nanogenerator#Triboelectric_nanogenerator
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21:35 < aedla> anyone near Hayward, CA who could help out?
21:35 < aedla> need to pick up some pipettes at an auction site and send to Europe
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--- Log closed Wed Sep 18 00:00:14 2019