--- Log opened Sun Dec 22 00:00:46 2019
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09:01 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=bbe0a1a6 Bryan Bishop: fix typo >> http://diyhpl.us/diyhpluswiki/transcripts/sf-bitcoin-meetup/2019-12-16-bip-taproot-bip-tapscript/
09:04 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c146a9fb Bryan Bishop: one more typofix >> http://diyhpl.us/diyhpluswiki/transcripts/sf-bitcoin-meetup/2019-12-16-bip-taproot-bip-tapscript/
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09:27 < kanzure> .tw https://twitter.com/_JustinMoon_/status/1168991333970829314
09:27 < EmmyNoether> Meet BitBoy: a stateless, QR-airgapped DIY Bitcoin hardware wallet https://video.twimg.com/ext_tw_video/1168991098871656449/pu/pl/T94dhwemaXN3DFN9.m3u8?tag=10 (@_JustinMoon_)
--- Log closed Sun Dec 22 09:34:29 2019
--- Log opened Sun Dec 22 09:34:29 2019
--- Log closed Sun Dec 22 09:44:03 2019
--- Log opened Sun Dec 22 09:44:03 2019
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10:01 < kanzure> "A genome-wide association study for extremely high intelligence" https://www.nature.com/articles/mp2017121
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12:05 < kanzure> "Full noncontact laser ultrasound: first human data" https://www.nature.com/articles/s41377-019-0229-8
12:47 < fenn> that's some sci-fi shit right there
12:49 < kanzure> "Here, we present full noncontact LUS results, imaging targets at ~5 cm depths and at a meter-scale standoff from the target surface. Experimental results demonstrating volumetric imaging and the first LUS images on humans are presented, all at eye- and skin-safe optical exposure levels. The progression of LUS imaging from tissue-mimicking phantoms, to excised animal tissue, to humans in ...
12:49 < kanzure> ...vivo is shown, with validation from conventional ultrasound images."
13:12 < kanzure> "Down syndrome causes about a third of cases of intellectual disability" wait that's pretty high..
14:04 < kanzure> "Intellectual ability and cortical development in children and adolescents" http://www.bic.mni.mcgill.ca/users/jason/reprints/Shaw2005Nature.pdf
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16:56 < darsie> yeah? If 3/100 have intellectual disability and 1 of them has down syndrome?
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17:24 < kanzure> "Environmentally induced changes to brain morphology predict cognitive performance" https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2017.0287
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17:29 < kanzure> "Artificial selection on brain size leads to matching changes in overall number of neurons" https://onlinelibrary.wiley.com/doi/pdf/10.1111/evo.13805
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18:25 < kanzure> "Establishing cerebral organoids as models of human-specific brain evolution" https://www.biorxiv.org/content/biorxiv/early/2018/12/19/500934.full.pdf
18:34 < kanzure> "A catalog of single nucleotide changes distinguishing modern humans from archaic hominins" https://www.nature.com/articles/s41598-019-44877-x
18:34 < kanzure> "Together with efforts to explore present-day human diversity22, this progress has allowed to narrow down the number of candidate point mutations from ~35 million differences since the split from chimpanzee when comparing only reference genomes23 to 31,389 fixed human-specific changes in a previous seminal study1"
19:21 < kanzure> "Enhancing our brains: Genomic mechanisms underlying cortical evolution" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832537/
19:22 < kanzure> "The first evidence that changes in ncHAR influence brain function came in 2015 when Boyd and colleagues identified HARE5 as an enhancer of FZD8 [28]. FZD8 encodes a receptor in the canonical Wnt signaling pathway, a pathway known to influence cortical size [30]. While the HARE5 locus was previously identified as human-accelerated [110], this group discovered that it had species-specific ...
19:22 < kanzure> ...enhancer activity in the developing neocortex, with human HARE5 active earlier and more robustly than chimpanzee HARE5. By creating transgenic mouse strains in which human or chimpanzee HARE5 was inserted upstream of the mouse FZD8 coding region, the authors demonstrated that human HARE5 promotes faster progenitor proliferation when compared to chimpanzee HARE5. This increased proliferation ...
19:22 < kanzure> ...resulted in greater neuron production and ultimately a larger neocortex, lending further support to the radial unit hypothesis. Future studies of this mouse model and iPSCs will be of interest for further testing this hypothesis."
19:23 < kanzure> "Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex" http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.705.2420&rep=rep1&type=pdf
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19:45 < kanzure> "Tissue regeneration enhancer elements: a way to unlock endogenous healing power" https://sci-hub.tw/10.1002/dvdy.24676
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20:20 < kanzure> "We predicted faster progenitor proliferation would ultimately be associated with more neurons. To test this, we quantified the densities of FoxP1-positive neurons (mid-layers III-V), born between E13.5-E16.5, and FoxP2 neurons (deep-layer VI), born around E12.5 (Figures 4T-AA) within radial columns of E18.5 brains [40, 41]. Compared to chimpanzee, Hs-HARE5::Fzd8 brains showed a ...
20:20 < kanzure> ...significant 14% increase in the density of FoxP1 neurons, but no difference in FoxP2 neurons, nor any notable apoptosis. Thus, Hs-HARE5::Fzd8 brains contain a higher density of neurons that are produced beginning around E13.5. Together these data indicate that, compared to Pt-HARE5, Hs-HARE5 promotes faster progenitor cell cycle, which is ultimately associated with increased Foxp1 excitatory ...
20:20 < kanzure> ...neuron density, and overall larger cortical size."
21:38 < nmz787> .wik semaphorins
21:38 < EmmyNoether> "Semaphorins are a class of secreted and membrane proteins that were originally identified as axonal growth cone guidance molecules.  They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes." - https://en.wikipedia.org/wiki/Semaphorins
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23:05 < fenn> https://www.washingtonpost.com/national-security/justice-department-investigates-sci-hub-founder-on-suspicion-of-working-for-russian-intelligence/2019/12/19/9dbcb6e6-2277-11ea-a153-dce4b94e4249_story.html
23:08 < fenn> i guess there's some news in there if you squint real hard
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23:52 < nsh> disband the DOJ
23:53 < nsh> also the washintonpost combining their GDPR consent splash page with a subscription offer
23:53 < nsh> is obnoxious as fuck
23:53 < nsh> "a woman who runs a major Internet piracy operation"
23:53 < nsh> it's not piracy is it
23:53 < nsh> is a library piracy
23:54 < nsh> all of these people need to die.
23:54 < nsh> everyone who writes for the washington post needs to die and everyone who works for the US federal government needs to die. preferably at the hands of russian intelligence, or just fucking into the fucking sea
23:54 < nsh> *falling
23:56 < nsh> how reliant are you guys on this country of yours existing but i'm rapidly losing patience with it again
23:56 < nsh> *because
--- Log closed Mon Dec 23 00:00:46 2019