--- Log opened Thu Jan 09 00:00:03 2020
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05:14 < kanzure> oh okay.
05:47 < LeoTal> kanzure: Well, the mosquito thing is tricky because you pretty much get only one chance. It works because the wild population doesn't have Wolbachia, and your introduced population does. If the drive fails (the population recovers, or goes down but not enough to help much with stopping disease transmission), then you're stuck with the result. Also if your mosquitoes cross over with a population that's trying a different drive (e.g
05:47 < LeoTal> . sterile males vs suppressing a given disease) then it ruins the other drive too.
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07:00 < kanzure> "Translational regulation of non-autonomous mitochondrial stress response promotes longevity" https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30858-7
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10:14 < kanzure> .wik cramfs
10:14 < EmmyNoether> "The compressed ROM file system (or cramfs) is a free (GPL'ed) read-only Linux file system designed for simplicity and space-efficiency." - https://en.wikipedia.org/wiki/Cramfs
10:30 < kanzure> "Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904953/
10:30 < kanzure> i don't like the new look for pubmedcentral
10:31 < kanzure> https://github.com/crasm/vpnshift.sh
10:32 < superkuh> Yeah. It means an extra click for me. At least they have a 'classic' site though. There was a while there where pubmed wasn't usable at all. Then it was great for a few years. Now it's okay.
10:34 < kanzure> https://phillm.net/libgen-stats-table.php
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14:21 < andytoshi> nyt article on gene drives .. haven't read it yet but linking for archival purposes
14:22 < andytoshi> .title https://www.nytimes.com/2020/01/08/magazine/gene-drive-mosquitoes.html
14:22 < EmmyNoether> gene-drive-mosquitoes
14:22 < andytoshi> "The Gene Drive Dilemma: We Can Alter Entire Species, but Should We" by Jennifer Kahn
14:29 < andytoshi> has lots of interesting discussion of history of public perception about genetic research and seems (40% through..) to be pro-information, anti-patent, anti-censorship
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14:32 < kanzure> saying we'll wipe out of the misquitoes is disingenuous; there's no way you can force people to give up their mosquitos and we'll have no colonies in any labs.
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14:59 < LeoTal> kanzure: I assume people who say "wipe out the mosquitoes" (either for or against) mean "in the wild". Smallpox is eradicated, but we have two (IIRC) samples.
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15:45 < kanzure> how do we have only two samples? ugh
15:45 < kanzure> that's awful
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15:55 < LeoTal> If for some reason you need to make smallpox from scratch, you can probably synthesise it from just the genome (we've done that for horse pox, but not for smallpox, because that would be suicidally stupid). Smallpox is highly infectious in pretty much any form you can store it in, and if you catch it you will die a lot, so it's not a great idea to have tons of it around. Also what do you want to do with smallpox samples?
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16:15 < andytoshi> yeah i'd bet you can synthesize it
16:15 < andytoshi> when i had a gf who was doing bioinformatics it'd always creep me the hell out when she'd show me ASCII representations of virus genomes
16:16 < kanzure> here you go https://diyhpl.us/~bryan/papers2/bio/genomes/viruses/
16:17 < LeoTal> The horse pox thing (which was explicitly meant to be a model of smallpox) was done in a small lab for $100k. So yeah you can afford your very own smallpox.
16:33 < kanzure> .wik zerodium
16:33 < EmmyNoether> "Zerodium is an American information security company founded in 2015 based in Washington, D.C.. Its main business is acquiring premium zero-day vulnerabilities with functional exploits from security researchers and companies, and reporting the research, along with protective [...]" - https://en.wikipedia.org/wiki/Zerodium
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--- Log closed Fri Jan 10 00:00:02 2020