--- Log opened Mon Jan 20 00:00:14 2020 00:12 -!- berndj [~berndj@azna.co.za] has quit [Ping timeout: 260 seconds] 00:16 -!- berndj [~berndj@azna.co.za] has joined ##hplusroadmap 00:31 -!- HumanG33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 00:32 -!- HumanG33k [~HumanG33k@62.147.242.8] has quit [Remote host closed the connection] 00:33 -!- HumanG33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 01:26 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:29 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 265 seconds] 02:06 -!- CRM114 is now known as Urchin 03:42 < maaku> "this end towards enemy" 03:51 < nsh> that would allow for incredibly energy release 03:52 < nsh> (inverse baryogenesis) 03:53 < nsh> oh, except it's claimed the universe simply wouldn't have a globally consistent notion of charge sign 03:54 < nsh> so maybe there wouldn't be mutual annihilation 03:55 < nsh> fun fact though: a mobius strip can controvert a 2-torus to the klein bottle and back 03:56 < nsh> (if you add/affix a mobious strip to a 2-torus then it can be continuously topologically transformed into a klein bottle and vice versa) 04:10 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 258 seconds] 04:26 -!- preview [~quassel@2407:7000:8423:b00::3] has quit [Ping timeout: 260 seconds] 04:31 -!- preview [~quassel@2407:7000:8423:b00::3] has joined ##hplusroadmap 04:37 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 05:06 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has quit [Read error: Connection reset by peer] 05:06 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has joined ##hplusroadmap 05:56 -!- superjen96 [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has quit [Read error: Connection reset by peer] 06:03 < maaku> .title https://www.nature.com/articles/d41586-019-03951-0 06:03 < EmmyNoether> A watershed moment for protein structure prediction 06:32 < lsneff> nsh: maybe a NOW would flip time direction as well so you'd end up back where you started? 06:37 < nsh> surewhynot 06:37 < nsh> C*P*T is the most universally preserved symmetry 06:37 < nsh> or conserved even 06:38 < nsh> but time may have more than just a sign parity 06:38 < nsh> differently gauged observers may have unique 'directions' in time in some number of dimensions 06:38 < nsh> who knows. humans aren't very good at understanding time 06:38 < nsh> time is a lot better at processing humans 06:42 < kanzure> https://www.genomeweb.com/business-news/revocation-broad-institute-crispr-patent-upheld-europe 06:42 < nsh> .t https://twitter.com/the01programmer/status/1219130084918988800 06:43 < EmmyNoether> The US Patent and Trademark Office gave out 333,530 patents in 2019...a 15% jump annually. Most patented things were: Crispr, hybrid plant creation, car dashboards (which were big at CES), and 3D printing.... https://www.facebook.com/100002302809698/posts/2704065103013557/ (@the01programmer) 06:43 < nsh> .t https://www.juve-patent.com/news-and-stories/cases/epo-revokes-broad-institute-patent-but-its-just-the-beginning-for-crispr-cas/ 06:43 < nsh> genomeweb loginwalled 06:43 < EmmyNoether> EPO revokes Broad Institute patent - but it's just the beginning for CRISPR-Cas - JUVE Patent 06:47 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 06:51 < kanzure> electrochemical machining of a rifle barrel https://twitter.com/FuggGunControl/status/1216550662894432256 07:09 -!- filipepe [uid362247@gateway/web/irccloud.com/x-rcwohzcvfgzwfzvv] has joined ##hplusroadmap 07:09 < kanzure> .tw https://twitter.com/peterktodd/status/1219271084803002368 07:09 < EmmyNoether> Speaking of, I'm inclined to give @kanzure push access to the repo to give him the ability to maintain it. // I'm not terribly interested in doing more Python for fun, and no-one is paying me to maintain python-bitcoinlib. // Interested if people have any objections. https://twitter.com/kanzure/status/1219270537668714501 (@peterktodd) 07:17 < kanzure> .tw https://twitter.com/kallewoof/status/1218172815376965633 07:17 < EmmyNoether> #btcdeb updated with 2 new features: mock signatures (h/t @kanzure for the idea) and inline operators. You can now do this: // btcdeb '[sig1 pub1 OP_DUP OP_HASH160 hash160(pub1) OP_EQUALVERIFY OP_CHECKSIG]' --pretend-valid=sig1:pub1 // See details here: https://github.com/kallewoof/btcdeb/blob/master/doc/mock-values.md (@kallewoof) 07:19 < kanzure> fuzz testing https://bitcoincore.reviews/17860.html 07:22 < kanzure> .title https://lists.linuxfoundation.org/pipermail/lightning-dev/2020-January/002425.html 07:22 < EmmyNoether> [Lightning-dev] Speculations on hardware wallet support for Lightning 07:25 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 07:29 -!- HumanG33k [~HumanG33k@62.147.242.8] has quit [Remote host closed the connection] 07:36 < kanzure> argument for transcripts: you're telling me you have a meeting or a conference with 50-100 people, all of whom have time that is valued at least $50/hour, and you can't pay rev.com $60 for 1 hour of transcripts? that's absurd. 07:39 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 258 seconds] 07:41 -!- llloid [~htemp@2a02:2788:1028:d2c:91e2:3658:7062:b98c] has joined ##hplusroadmap 07:41 < kanzure> llloid: be greeted 07:44 -!- not_you [~whaun@c-68-81-194-160.hsd1.pa.comcast.net] has joined ##hplusroadmap 07:44 < kanzure> "It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures3. Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we ... 07:44 < kanzure> ...construct a potential of mean force4 that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences." 07:45 -!- llloid [~htemp@2a02:2788:1028:d2c:91e2:3658:7062:b98c] has quit [Client Quit] 07:45 < kanzure> https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery 07:46 < kanzure> "ProSPr: Democratized implementation of AlphaFold protein distance prediction network" https://www.biorxiv.org/content/10.1101/830273v2 07:46 < kanzure> https://github.com/dellacortelab/prospr 07:46 < kanzure> ugh "All of the data used to train the ProSPr models (~2TB) is publically accessible at https://files.physics.byu.edu/data/prospr/ 07:49 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 07:56 < kanzure> https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13 07:57 -!- dustinm [~dustinm@static.38.6.217.95.clients.your-server.de] has quit [Quit: Leaving] 07:59 < kanzure> do we have a protein folding wish list? 07:59 -!- dustinm [~dustinm@static.38.6.217.95.clients.your-server.de] has joined ##hplusroadmap 08:00 < kanzure> something about molecular protein legos 08:00 < kanzure> and long-tube proteins that have molecular factories inside (which are evidently natural) 08:09 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Quit: leaving] 08:17 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=c6f875df Bryan Bishop: long-overdue basic wishlist for protein engineering >> http://diyhpl.us/diyhpluswiki/protein-engineering/ 08:23 -!- not_you [~whaun@c-68-81-194-160.hsd1.pa.comcast.net] has quit [Ping timeout: 272 seconds] 08:25 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=78fd5411 Bryan Bishop: a few more protein engineering wishlist items >> http://diyhpl.us/diyhpluswiki/protein-engineering/ 08:25 < kanzure> https://diyhpl.us/wiki/protein-engineering 08:38 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 08:44 < lsneff> kanzure: "long-tube protein molecular-chemistry factories" sounds very interesting 08:49 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-urivvydevjnskypg] has joined ##hplusroadmap 08:54 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has joined ##hplusroadmap 09:20 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has quit [] 09:22 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has joined ##hplusroadmap 09:22 -!- jenelizabeth [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has joined ##hplusroadmap 09:24 -!- superjen96 [jenelizabe@gateway/vpn/privateinternetaccess/jenelizabeth] has joined ##hplusroadmap 09:25 -!- jeneliza_ [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has joined ##hplusroadmap 09:25 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:2817:4767:6c79:c1a5] has joined ##hplusroadmap 09:26 -!- superjen96 [jenelizabe@gateway/vpn/privateinternetaccess/jenelizabeth] has quit [Read error: Connection reset by peer] 09:26 < kanzure> lsneff: it's in the logs somewhere.. 09:27 -!- jenelizabeth [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has quit [Ping timeout: 260 seconds] 09:39 -!- preview [~quassel@2407:7000:8423:b00::3] has quit [Ping timeout: 245 seconds] 09:39 < kanzure> "Enzyme clustering accelerates processing of intermediates through metabolic channeling" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666537/ 09:40 < kanzure> "We present a quantitative model to demonstrate that coclustering multiple enzymes into compact agglomerates accelerates the processing of intermediates, yielding the same efficiency benefits as direct channeling, a well-known mechanism in which enzymes are funneled between enzyme active sites through a physical tunnel" 09:46 < kanzure> "Polyketide and non-ribosomal peptide synthases: Falling together by coming apart" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC152231/ 09:46 < kanzure> "... These enzymes represent some of the largest proteins known, and, as a consequence of their multifunctional character, a single protein can catalyze dozens of discrete biochemical reactions. For example, the rapamycin PKS (3) and cyclosporin NRPS (4) catalyze 51 and 40 steps in assembly of their respective products. .." 09:47 < kanzure> .wik polyketide synthase 09:47 < EmmyNoether> "Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages." - https://en.wikipedia.org/wiki/Polyketide_synthase 09:48 < kanzure> from http://gnusha.org/logs/2015-01-19.log 09:49 < kanzure> .wik nonribosomal peptide 09:49 < EmmyNoether> "Nonribosomal peptides (NRP) are a class of peptide secondary metabolites, usually produced by microorganisms like bacteria and fungi." - https://en.wikipedia.org/wiki/Nonribosomal_peptide 09:49 < kanzure> "Nonribosomal peptides are synthesized by nonribosomal peptide synthetases, which, unlike the ribosomes, are independent of messenger RNA. Each nonribosomal peptide synthetase can synthesize only one type of peptide." 09:50 < kanzure> ".. the first fungal NRP to be found was ciclosporin. It is synthesized by a single 1.6MDa NRPS.[4]" 09:50 < kanzure> aka "specialized nonribosomal peptide-synthetase (NRPS) enzyme" 09:53 < kanzure> https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnature13423/MediaObjects/41586_2014_Article_BFnature13423_Fig1_HTML.jpg 09:56 < kanzure> i think this might be an example https://www.uniprot.org/uniprot/Q58085 09:58 < kanzure> https://www.youtube.com/watch?v=IUw3fvpinSs&t=35s 09:59 -!- sektor [~sektor@95.87.234.241] has joined ##hplusroadmap 10:01 < kanzure> that video has a good visualization 10:10 -!- preview [~quassel@2407:7000:8423:b00::3] has joined ##hplusroadmap 10:11 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-lpelrpwmoekwlkcc] has quit [Read error: Connection reset by peer] 10:11 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-biiussxtjkuydsxb] has joined ##hplusroadmap 10:17 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 10:24 < lsneff> .title https://caseyhandmer.wordpress.com/2020/01/20/what-would-it-be-like-to-work-on-mars/ 10:24 < EmmyNoether> What would it be like to work on Mars? - Casey Handmer's blog 10:37 -!- Alchemical_ [~al@unaffiliated/alchemical] has joined ##hplusroadmap 10:39 -!- Alchemical [~al@unaffiliated/alchemical] has quit [Ping timeout: 240 seconds] 10:42 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has quit [] 10:42 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has joined ##hplusroadmap 10:54 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has quit [] 12:03 < archels> "I call myself a *Senior Research Fellow*, but in the end I'm just a postdoc in the late 40s who has almost no chances to get full tenure and has messed up his life for good." 12:06 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-urivvydevjnskypg] has quit [Quit: Connection closed for inactivity] 12:16 < archels> 29th Annual Computational Neuroscience Meeting - https://www.cnsorg.org/cns-2020-melbourne-australia 12:17 < archels> queue the jokes about will we make it out alive 12:17 < archels> (it's in Melbourne, Australia this year) 12:20 < LeoTal> archels: Is this open to random gawkers who just want to listen to fancy researchers talk about their fancy research? I don't miss the academia grinder but I do miss the larnin' 12:23 < archels> I can't really give you any first-hand account, as I've never gone before 12:38 < LeoTal> I meant legally. Like can you register to attend as a rubbernecker and when they ask what institution you're affiliated with say "oh I'm a cashier at Macca's, I just like listening to stuff about the cerebellum" 12:54 -!- Codaraxis [~Codaraxis@221.sub-174-195-203.myvzw.com] has joined ##hplusroadmap 12:59 -!- Codaraxis [~Codaraxis@221.sub-174-195-203.myvzw.com] has quit [Read error: Connection reset by peer] 13:02 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has quit [Remote host closed the connection] 13:03 -!- jenelizabeth [jenelizabe@gateway/vpn/privateinternetaccess/jenelizabeth] has joined ##hplusroadmap 13:06 -!- jeneliza_ [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has quit [Ping timeout: 268 seconds] 13:25 -!- superjen96 [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has joined ##hplusroadmap 13:26 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has joined ##hplusroadmap 13:28 -!- jenelizabeth [jenelizabe@gateway/vpn/privateinternetaccess/jenelizabeth] has quit [Read error: Connection reset by peer] 13:43 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-aicqqpeqaqixcwcw] has joined ##hplusroadmap 14:20 -!- Codaraxis [~Codaraxis@2600:1012:b147:7105:e0f9:6240:9a28:7f6f] has joined ##hplusroadmap 14:31 -!- jenelizabeth [jenelizabe@gateway/vpn/privateinternetaccess/jenelizabeth] has joined ##hplusroadmap 14:34 -!- superjen96 [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has quit [Ping timeout: 268 seconds] 14:36 -!- sektor [~sektor@95.87.234.241] has quit [Ping timeout: 268 seconds] 15:00 < fenn> "Ciclosporin has been investigated as a possible neuroprotective agent in conditions such as traumatic brain injury, and has been shown in animal experiments to reduce brain damage associated with injury" 15:01 < kanzure> how old is atp synthetase? 15:01 < fenn> older than dinosaurs 15:01 < fenn> probably a couple billion years 15:01 -!- not_you [~whaun@c-68-81-194-160.hsd1.pa.comcast.net] has joined ##hplusroadmap 15:03 < fenn> or much older if you subscribe to the panspermia theory of the origin of earth-bound life 15:03 < kanzure> ".. This link is tenuous, however, as the overall structure of flagellar motors is far more complex than that of the FO particle and the ring with about 30 rotating proteins is far larger than the 10, 11, or 14 helical proteins in the FO complex." 15:04 < kanzure> "The modular evolution theory for the origin of ATP synthase suggests that two subunits with independent function, a DNA helicase with ATPase activity and a H+ 15:04 < kanzure> motor, were able to bind, and the rotation of the motor drove the ATPase activity of the helicase in reverse.[13][17] This complex then evolved greater efficiency and eventually developed into today's intricate ATP synthases. Alternatively, the DNA helicase/H+ 15:04 < kanzure> motor complex may have had H+ 15:04 < kanzure> pump activity with the ATPase activity of the helicase driving the H+ 15:04 < kanzure> motor in reverse.[13] This may have evolved to carry out the reverse reaction and act as an ATP synthase.[14][18][19]" 15:05 < fenn> it's present in archaea 15:05 < kanzure> i mean.. how much search space can you go through in 1-2 billion years? 15:07 < fenn> "Given that archaea and bacteria contrast so sharply in the composition of their membranes, it is quite surprising that one type of membrane protein is universally conserved and clearly attributable to LUCA, namely the ATP synthase" 15:07 < fenn> apparently archaea have more diverse atp synthases 15:07 < nsh> .wik Ciclosporin 15:08 < EmmyNoether> "Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is taken by mouth or by injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent [...]" - https://en.wikipedia.org/wiki/Ciclosporin 15:08 < nsh> i've been trialled on ciclosporin but it go very far 15:08 < nsh> might get offered it again at my next dermatology consultation 15:08 < nsh> bit dubious about immunesuppressants but being on prednisolone indefinitely isn't great either 15:11 -!- ebowden [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 15:12 -!- ebowden_ [~ebowden@unaffiliated/ebowden] has joined ##hplusroadmap 15:16 -!- ebowden [~ebowden@unaffiliated/ebowden] has quit [Ping timeout: 268 seconds] 15:19 < nsh> "This is indeed theological mathematics proving at most two Gods suffices to convince you of divine intervention." 15:19 < nsh> - [comment to] https://rjlipton.wordpress.com/2020/01/15/halting-is-poly-time-quantum-provable/ 15:32 -!- not_you [~whaun@c-68-81-194-160.hsd1.pa.comcast.net] has quit [Ping timeout: 260 seconds] 15:45 < nsh> .t https://www.independent.co.uk/news/health/cancer-treatment-therapy-t-cell-universal-tumor-cardiff-university-a9292716.html 15:45 < EmmyNoether> Breakthrough discovery could lead to 'one-size-fits-all' cancer treatment | The Independent 15:46 < nsh> -> https://www.cardiff.ac.uk/news/view/1749599-discovery-of-new-t-cell-raises-prospect-of-universal-cancer-therapy 15:47 < nsh> -> https://www.nature.com/articles/s41590-019-0578-8 15:47 < nsh> .t 15:47 < EmmyNoether> Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 | Nature Immunology 15:53 -!- Codaraxis [~Codaraxis@2600:1012:b147:7105:e0f9:6240:9a28:7f6f] has quit [Read error: Connection reset by peer] 16:01 -!- superjen96 [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has joined ##hplusroadmap 16:03 -!- Codaraxis [~Codaraxis@221.sub-174-195-203.myvzw.com] has joined ##hplusroadmap 16:04 -!- jenelizabeth [jenelizabe@gateway/vpn/privateinternetaccess/jenelizabeth] has quit [Ping timeout: 258 seconds] 16:28 -!- filipepe [uid362247@gateway/web/irccloud.com/x-rcwohzcvfgzwfzvv] has quit [Quit: Connection closed for inactivity] 16:53 -!- turona [~quassel@2a01:c23:6021:6100:fdc0:42b:fa74:4068] has quit [Ping timeout: 272 seconds] 16:54 -!- turona [~quassel@2a01:c22:a43d:8900:2048:a467:cebd:cc4d] has joined ##hplusroadmap 17:10 -!- yashgaroth [~ffffffff@2606:6000:ca84:b300:2817:4767:6c79:c1a5] has quit [Ping timeout: 260 seconds] 17:23 -!- filipepe [uid362247@gateway/web/irccloud.com/x-dfrlaujoqfaqocwk] has joined ##hplusroadmap 17:46 -!- not_you [~whaun@c-68-81-194-160.hsd1.pa.comcast.net] has joined ##hplusroadmap 17:56 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-aicqqpeqaqixcwcw] has quit [Quit: Connection closed for inactivity] 18:13 < lsneff> .title https://blogs.scientificamerican.com/life-unbounded/death-on-mars1/ 18:13 < EmmyNoether> Death on Mars - Scientific American Blog Network 18:17 -!- Codaraxis [~Codaraxis@221.sub-174-195-203.myvzw.com] has quit [Ping timeout: 240 seconds] 18:25 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has quit [Quit: Leaving.] 18:31 -!- mauz555 [~mauz555@2a01:e35:8ab1:dea0:aca5:c811:ea2e:974b] has quit [] 18:41 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 268 seconds] 18:48 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 18:52 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=1b7e791d Bryan Bishop: more protein engineering wishlist >> http://diyhpl.us/diyhpluswiki/protein-engineering/ 18:59 < fenn> actually, the radiation problem _can_ be overstated 19:02 < kanzure> yaml docs aren't that good 19:03 < fenn> better than markdown 19:08 < fenn> i'm really unimpressed by scientific american recently 19:12 < fenn> i use yaml a lot for folding hierarchical notes to myself 19:17 < darsie> "The martian radiation environment is a problem for human explorers that cannot be overstated" "This past week Musk brought the idea up again, in typically provocative fashion" 19:23 * darsie proposed 27 m or so rubble on halls for pressure and radiation shielding. 19:28 -!- adlai [~adlai@unaffiliated/adlai] has quit [Ping timeout: 258 seconds] 19:34 -!- adlai [~adlai@unaffiliated/adlai] has joined ##hplusroadmap 19:38 -!- filipepe [uid362247@gateway/web/irccloud.com/x-dfrlaujoqfaqocwk] has quit [Quit: Connection closed for inactivity] 19:44 -!- not_you [~whaun@c-68-81-194-160.hsd1.pa.comcast.net] has quit [Ping timeout: 272 seconds] 19:52 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 20:04 -!- preview [~quassel@2407:7000:8423:b00::3] has quit [Ping timeout: 260 seconds] 20:48 -!- fox2p [~fox2p@cpe-66-108-32-173.nyc.res.rr.com] has quit [Ping timeout: 268 seconds] 20:50 -!- fox2p [~fox2p@cpe-66-108-32-173.nyc.res.rr.com] has joined ##hplusroadmap 20:59 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds] 21:13 -!- preview [~quassel@210.246.32.248] has joined ##hplusroadmap 21:29 -!- preview [~quassel@210.246.32.248] has quit [Ping timeout: 240 seconds] 21:35 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 21:39 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Ping timeout: 268 seconds] 21:40 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has joined ##hplusroadmap 21:52 -!- preview [~quassel@2407:7000:8423:b00::3] has joined ##hplusroadmap 22:17 -!- preview [~quassel@2407:7000:8423:b00::3] has quit [Ping timeout: 260 seconds] 22:18 < maaku> She way overstated the radiation problem 22:18 < maaku> Put some sandbags on the roof. Done. 22:30 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has quit [Read error: Connection reset by peer] 22:34 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has joined ##hplusroadmap 22:40 -!- Codaraxis_ [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 22:43 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has quit [Ping timeout: 268 seconds] 22:43 -!- LeoTal [~Adium@117.170.86.79.rev.sfr.net] has quit [Quit: Leaving.] 23:17 < nmz787> man, software is so much easier than anything hardware related... just for the shear reason of having to get up and change environments, more physical movement... ugh, what a strange feeling of self-disappointment 23:42 * nsh is reminded of the Asimov robots story "Victory Unintended" 23:42 < nsh> (re: putting mammals on Mars) 23:48 < nmz787> I can't even find my hot glue gun... I found the glue sticks... but no gun....... how am I ever supposed to get atomic layer deposition working, let along this stupid MOSFET PWMing of a heater 23:48 < nmz787> ugh --- Log closed Tue Jan 21 00:00:15 2020