--- Log opened Thu Mar 26 00:00:34 2020 01:06 -!- Netsplit *.net <-> *.split quits: midnight, saxo, kuldeep 01:06 -!- Netsplit over, joins: saxo 01:08 -!- Netsplit over, joins: kuldeep 01:19 -!- HumanGeek [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 01:22 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Ping timeout: 250 seconds] 02:03 -!- pepesza [~pepesza@185.83.218.228] has quit [Ping timeout: 258 seconds] 02:19 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 02:22 -!- Guest29865 [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 03:54 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 04:09 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Remote host closed the connection] 04:11 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 04:21 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 04:41 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:e9f4:57b2:ae91:a2c1] has joined ##hplusroadmap 05:17 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 05:18 -!- TC is now known as Guest42630 05:20 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 240 seconds] 05:59 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 06:01 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:e9f4:57b2:ae91:a2c1] has quit [Remote host closed the connection] 06:01 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has joined ##hplusroadmap 06:01 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has quit [Remote host closed the connection] 06:02 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has joined ##hplusroadmap 06:02 -!- Guest42630 [~talinck@98.29.27.253] has quit [Ping timeout: 256 seconds] 06:08 -!- fltrz [~fltrz@109.236.129.249] has joined ##hplusroadmap 06:09 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has quit [Read error: Connection reset by peer] 06:10 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has joined ##hplusroadmap 06:26 -!- yashgaroth [~ffffffff@172.58.22.238] has joined ##hplusroadmap 06:26 < lsneff> .tw 1242918035788365830 06:26 < saxo> Thanks to our AMAZING community, we’ve crossed the exaFLOP barrier! That’s over a 1,000,000,000,000,000,000 operations per second, making us ~10x faster than the IBM Summit! https://video.twimg.com/tweet_video/ET-7XOQXsAkCWWU.mp4 (@foldingathome) 07:26 -!- aeiousom1thing [~aeiousome@unaffiliated/aeiousomething] has joined ##hplusroadmap 07:29 -!- aeiousomething [~aeiousome@unaffiliated/aeiousomething] has quit [Ping timeout: 264 seconds] 07:30 -!- gwillen [~gwillen@unaffiliated/gwillen] has quit [Ping timeout: 240 seconds] 07:30 -!- berndj [~berndj@197.242.93.82] has quit [Ping timeout: 264 seconds] 07:30 -!- sivoais [~zaki@unaffiliated/sivoais] has quit [Ping timeout: 264 seconds] 07:30 -!- berndj [~berndj@azna.co.za] has joined ##hplusroadmap 07:31 -!- sivoais [~zaki@199.19.225.239] has joined ##hplusroadmap 07:31 -!- dongcarl [~dongcarl@unaffiliated/dongcarl] has quit [Read error: Connection reset by peer] 07:31 -!- gwillen [~gwillen@li450-236.members.linode.com] has joined ##hplusroadmap 07:31 -!- sivoais [~zaki@199.19.225.239] has quit [Changing host] 07:31 -!- sivoais [~zaki@unaffiliated/sivoais] has joined ##hplusroadmap 07:31 -!- gwillen [~gwillen@li450-236.members.linode.com] has quit [Changing host] 07:31 -!- gwillen [~gwillen@unaffiliated/gwillen] has joined ##hplusroadmap 08:01 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 08:04 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 240 seconds] 08:04 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 08:04 -!- TC is now known as Guest52150 08:07 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 08:37 -!- pompolic [~A@unaffiliated/pompolic] has quit [Ping timeout: 265 seconds] 08:39 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 08:55 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 09:19 -!- HumanGeek [~HumanG33k@62.147.242.8] has quit [Read error: Connection reset by peer] 09:20 -!- HumanGeek [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 09:26 < fenn> Humanity is a massively parallel supercomputer. Each of our immune systems confronts and solves challenges presented by invaders.  The answers are in our bloods. During 09:26 < fenn> epidemics we network our bloods.  (Social distancing on one hand.  Maximal intimacy on the other.) 09:26 < fenn> 09:26 < fenn> Banking this blood and analyzing the nature and character of immune responses (most simple version: which antibodies are built) by different humans in response to the 09:27 < fenn> pathogen is hugely important for basic science but also has immediate implications. 09:28 < fenn> "If we really are in an exponential phase, transfusions from the recovered couldn't possibly help most people.  It's one of these old hacks that clinicians love but that end up being hugely difficult logistically to scale up to treat a larger population" 09:29 < fenn> "We know how to mass-produce Abs.  It's just that it's normally a many-year testing and approval process... but if your safety benchmark is injecting some rando's plasma, why don't we fast track the hell out of anti-sars-cov-2 biologics?" 09:31 < kanzure> because regulations shouldn't be removed in war time: they made their bed, now they should sleep in it 09:32 < kanzure> they shouldn't get a temporary exemption just because they realize their policy is completely stupid 09:32 < kanzure> they need to assess their shortcomings and permanently fix these regulations 09:32 < fltrz> fenn, perhaps the answer to covid-19 is 42? then the computation can be halted 09:34 < kanzure> before it was only a sort of hypothetical death of people they were okay with, but suddenly when it's their own lives on the line they want to temporary change things? no 09:39 < Urchin> fenn: afaik, some did use plasma of the recovered people on sick patients 09:39 < Urchin> ok, I need sleep 09:41 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 09:48 < yashgaroth> even throwing all safety testing out the window, it still takes months to get a stable cell line expressing a monoclonal at a useful titer, and 99% of large-scale monoclonal manufacturing capacity is already busy producing stuff like avastin 24/7 09:49 < kanzure> .tw https://twitter.com/kanzure/status/1243216587689263104 09:49 < saxo> So we had all this red tape + regulations for medicine/drugs/tech, and suddenly we want to temporarily bypass because emergency? Now OK? // We must say no: either rescind the red tape and the Federal Death Agency (FDA), or don't: live with the consequences. // https://www.capitalismmagazine.com/2019/07/the-federal-death-agency-fda/ (@kanzure) 09:49 < yashgaroth> and say what you will about the safety bar of 'someone else's blood', at least the plasma has been shown as safe in the donor's body 09:51 < yashgaroth> but yes in the exponential phase the demand for convalescent serum will easily outstrip supply 10:02 < fenn> no kanzure, "they" _should_ get a temporary exemption, because it's destructive and harmful to everybody, not just the people who put the stupid policy in place 10:02 < fenn> the answer to a bad policy is not to nuke the world 10:03 < fenn> unless you're volunteering to be that guy who pours gasoline on himself on the FDA steps 10:05 < fenn> fltrz: if covid-19 = 42 then covid = 42+19 = 61 10:05 < fenn> i'll show myself out now 10:06 < kanzure> it's destructive and harmful to everybody **regardless* of the emergency 10:09 < fenn> ok how about a compromise. everybode else can skip the testing and regulations, but FDA staffers must only use treatments approved by the FDA 10:12 < kanzure> the line men were just following orders... hmm. 10:12 < kanzure> dumb orders, but still- they are probably low wage workers etc. 10:16 < fenn> i'm pretty sure the author of that "federal death agency" has misunderstood the meaning of the word "altruism" 10:16 < fenn> it does not mean "coercion" 10:21 < fltrz> fenn lol 10:23 < fenn> i generally agree with the substance of the article, if not the typical aggrieved randist tone 10:28 < fenn> tell mrgunn to RTFA as per his culture war hippocratic oath 10:38 * fenn considers continuing but realizes it's veering into politics and decides better of it 10:46 < juri_> it's easy to attack people online now. there's a lot of anger to go around. just try to own your piece of what might be helpful, and concentrate on that. 10:47 < juri_> ... and may the future have mercy on each of us who could have done more. 10:51 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has quit [] 11:14 < fenn> i haven't really seen a lot of anger, except directed towards the government 11:15 < fenn> right now i think it's more important to make damn sure you're saying correct things, rather than worrying about "could I have done more?" 11:15 < fenn> every person that sits in their room all day playing minecraft is a person not transmitting the virus 11:16 < fenn> do your part, hikikomoris of the world 12:01 < kanzure> social distancing? i've been practicing for years! https://xkcd.com/2276/ 12:01 < kanzure> it's neard heaven- everyone indoors, no meetings, no group gatherings, no contact allowed, and all sports canceled. 12:02 < kanzure> nerd* 12:13 < superkuh> Except for the constant terrible anxiety and uncertainty and grieving. 12:17 < kanzure> right, there's that. 12:20 < TMA> as if that were not the status quo ante 12:33 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 12:59 -!- midnight [~midnight@unaffiliated/midnightmagic] has joined ##hplusroadmap 13:20 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 13:21 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has joined ##hplusroadmap 13:23 -!- Guest52150 [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 13:52 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-rdafzamshjpsyzfp] has joined ##hplusroadmap 14:54 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 14:57 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 258 seconds] 14:57 -!- jtimon [~quassel@206.160.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 15:19 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 15:21 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 240 seconds] 15:30 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has quit [Remote host closed the connection] 15:30 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has joined ##hplusroadmap 15:35 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has quit [Ping timeout: 256 seconds] 15:56 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has joined ##hplusroadmap 16:01 -!- mauz555 [~mauz555@2a01:e0a:56d:9090:ed93:1afc:1e0c:84c9] has quit [Ping timeout: 272 seconds] 16:21 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-rdafzamshjpsyzfp] has quit [Quit: Connection closed for inactivity] 16:23 -!- helleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 16:25 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 260 seconds] 16:28 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 16:41 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-ayisdqwqphxzpygw] has joined ##hplusroadmap 16:43 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 16:57 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 17:01 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 250 seconds] 17:41 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 240 seconds] 18:30 -!- mauz555 [~mauz555@88.125.182.66] has joined ##hplusroadmap 18:35 -!- mauz555 [~mauz555@88.125.182.66] has quit [Ping timeout: 265 seconds] 18:49 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 19:03 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 19:37 -!- dongcarl [~dongcarl@unaffiliated/dongcarl] has joined ##hplusroadmap 19:52 -!- heath is now known as h 19:52 -!- h is now known as heath 20:23 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-ayisdqwqphxzpygw] has quit [Quit: Connection closed for inactivity] 20:34 -!- yashgaroth [~ffffffff@172.58.22.238] has quit [Quit: Leaving] 21:46 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 22:55 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 22:56 -!- TC is now known as Guest14395 22:59 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 264 seconds] --- Log closed Fri Mar 27 00:00:34 2020