--- Log opened Wed Apr 01 00:00:39 2020 00:00 -!- nsh [~lol@wikipedia/nsh] has joined ##hplusroadmap 00:02 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 00:10 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 00:48 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 246 seconds] 00:49 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 01:02 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 01:16 -!- Codaraxis_ [Codaraxis@gateway/vpn/mullvad/codaraxis] has joined ##hplusroadmap 01:20 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has quit [Ping timeout: 258 seconds] 01:23 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 01:29 -!- jtimon [~quassel@206.160.134.37.dynamic.jazztel.es] has joined ##hplusroadmap 02:12 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 02:12 -!- TC is now known as Guest77750 02:15 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 264 seconds] 02:22 -!- Codaraxis [Codaraxis@gateway/vpn/mullvad/codaraxis] has joined ##hplusroadmap 02:26 -!- Codaraxis_ [Codaraxis@gateway/vpn/mullvad/codaraxis] has quit [Ping timeout: 250 seconds] 02:39 -!- Codaraxis [Codaraxis@gateway/vpn/mullvad/codaraxis] has quit [Read error: Connection reset by peer] 02:43 -!- jenelizabeth [~jenelizab@185.92.25.103] has quit [Ping timeout: 265 seconds] 02:45 -!- iAmDecim [~iAmDecim@99-38-191-33.lightspeed.clmasc.sbcglobal.net] has joined ##hplusroadmap 02:49 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 02:50 -!- galambo [~galambo@84.247.48.163] has quit [Ping timeout: 256 seconds] 02:51 -!- adlai [~adlai@unaffiliated/adlai] has joined ##hplusroadmap 02:52 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 02:52 -!- jenelizabeth [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has joined ##hplusroadmap 02:53 -!- superjen96 [~jenelizab@185.92.25.103] has joined ##hplusroadmap 02:54 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 240 seconds] 02:57 -!- jenelizabeth [~jenelizab@cpc155793-brmb11-2-0-cust474.1-3.cable.virginm.net] has quit [Ping timeout: 256 seconds] 02:57 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 240 seconds] 03:33 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Remote host closed the connection] 03:35 -!- Human_G33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 03:56 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Quit: bye bye] 03:56 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 04:06 < nsh> the current excuse of the UK government (and media PR people) for lack of covid19 testing is 'shortage of reagents for PCR' 04:06 < nsh> which has to be the biggest crock of shit so far 05:02 -!- iAmDecim [~iAmDecim@99-38-191-33.lightspeed.clmasc.sbcglobal.net] has quit [Quit: WeeChat 1.9] 05:20 < kanzure> https://www.coindesk.com/github-is-burying-bitcoin-code-inside-an-arctic-mountain-to-ride-out-the-next-1000-years 05:57 -!- CRM114 [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 05:57 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Disconnected by services] 05:57 -!- CRM114 is now known as Urchin 07:20 < darsie> The Arctic (/ˈɑːrktɪk/ or /ˈɑːrtɪk/)[1][Note 1] is a polar region located at the northernmost part of Earth. The Arctic consists of the Arctic Ocean, adjacent seas, and parts of Alaska (United States), Finland, Greenland (Denmark), Iceland, Northern Canada, Norway, Russia, and Sweden. 07:48 -!- smjparsons [~smjparson@75.170.154.13] has joined ##hplusroadmap 07:48 < smjparsons> This is free for life if you use the coupon code [STAYINSIDEANDLEARN] today: https://www.udemy.com/course/practical-ethical-hacking/ 08:07 -!- smjparsons [~smjparson@75.170.154.13] has quit [Quit: Leaving] 08:07 -!- smjparsons [~smjparson@75.170.154.13] has joined ##hplusroadmap 08:26 -!- yashgaroth [~ffffffff@172.58.19.12] has joined ##hplusroadmap 08:34 -!- smjparsons [~smjparson@75.170.154.13] has quit [Quit: Leaving] 08:41 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-quhxwffqmjnjsmcc] has joined ##hplusroadmap 08:41 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 246 seconds] 08:57 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 09:27 -!- spaceangel [~spaceange@ip-89-177-23-46.net.upcbroadband.cz] has joined ##hplusroadmap 09:30 < kanzure> .tw https://twitter.com/dj_bitwreck/status/1245387625344753664 09:30 < saxo> @_drgo @kanzure @CaitlinLong_ BULLISH ON KANZURE (@dj_bitwreck, in reply to tw:1245381673350389760) 09:30 < kanzure> (fan club stuff) 09:31 -!- spaceangel [~spaceange@ip-89-177-23-46.net.upcbroadband.cz] has quit [Ping timeout: 256 seconds] 10:17 -!- filipepe [uid362247@gateway/web/irccloud.com/x-zuasuldttxilygru] has joined ##hplusroadmap 10:25 < lsneff> kanzure: Do you know what happened to Mark Sims, the founder of nanorex? 10:39 < kanzure> lsneff: he quit. he handed me the keys to the source code and that's where https://github.com/kanzure/nanoengineer comes from. 10:43 < lsneff> kanzure: Do you know what he’s doing now? 10:55 -!- Urchin [~urchin@unaffiliated/urchin] has quit [Remote host closed the connection] 11:07 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 11:09 -!- superjen96 [~jenelizab@185.92.25.103] has quit [Ping timeout: 264 seconds] 11:11 -!- shawwwn [uid6132@gateway/web/irccloud.com/x-quhxwffqmjnjsmcc] has quit [Quit: Connection closed for inactivity] 11:12 -!- jenelizabeth [~jenelizab@185.92.25.103] has joined ##hplusroadmap 12:03 < archels> what does it mean to be bullish on someone? 12:04 < TMA> archels: == to expect the price to rise 12:04 < TMA> wall street slang 12:05 < fenn> you'd want to invest in them, hypothetically 12:07 < TMA> willing to enter a long position rather, it need not be an investment, speculation is another valid motive 12:49 < kanzure> lsneff: i assume he's just spending his time doing "ball room dancing" that seems to be his current hobby 12:56 < kanzure> .title https://github.com/oskardolch/SteamCAD 12:56 < saxo> GitHub - oskardolch/SteamCAD: 2D CAD especially designed to draw steam locomotives 12:57 -!- filipepe [uid362247@gateway/web/irccloud.com/x-zuasuldttxilygru] has quit [Quit: Connection closed for inactivity] 13:03 < lsneff> kanzure: Interesting. Thanks for letting me know. 13:08 -!- dongcarl [~dongcarl@unaffiliated/dongcarl] has quit [Ping timeout: 264 seconds] 13:16 -!- Guest77750 is now known as helleshin 13:45 -!- jtimon [~quassel@206.160.134.37.dynamic.jazztel.es] has quit [Remote host closed the connection] 13:52 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Remote host closed the connection] 13:54 -!- Human_G33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 14:02 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 14:03 < fltrz> proteins tagged with the ubiquitin protein are broken down by proteasomes, is there an analog of ubiquitin for RNA degradation? 14:03 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 14:05 < fenn> RNA is constantly being broken down in the normal case 14:05 < fltrz> fenn, right, but thats also what I thought about proteins, catabolism and anabolism, I thought they were simply in equilibrium without much thought about them getting tagged with ubiquitin 14:06 < fltrz> hence my question, by what is RNA broken down, and is there a marker analogous to ubiquitin that marks the RNA polymer molecule to be broken down? 14:06 < fenn> "The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA 14:06 < fenn> degradation. This is also sometimes the case for eukaryotic non-coding RNAs." 14:07 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 260 seconds] 14:07 < fltrz> ok so we do the opposite as bacterian, presumably to prevent bacterial infection? 14:09 < fltrz> fenn, once the poly(A) tail is short enough, it is tagged by an analog of ubiquitin or it is recognized by the proteins that break it down? also what shortens the poly(A) tail? translation? 14:11 < fenn> i get the impression it's constantly being nibbled upon, (by poly-A binding protein?) and poly-A binding protein prevents the enzymatic degradation 14:13 < fenn> oh it adds the poly-A, nm 14:28 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 14:31 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 260 seconds] 14:48 -!- urkk_ [~urkk@98.240.17.95.dynamic.jazztel.es] has joined ##hplusroadmap 14:51 -!- urkk [~urkk@27.134.239.188.dynamic.jazztel.es] has quit [Ping timeout: 256 seconds] 15:00 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Quit: Leaving] 15:00 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 15:02 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Client Quit] 15:03 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 15:03 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Remote host closed the connection] 15:03 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 15:08 -!- Netsplit *.net <-> *.split quits: AgenttiX 15:15 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Remote host closed the connection] 15:19 -!- Human_G33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 15:20 -!- Human_G33k [~HumanG33k@62.147.242.8] has quit [Remote host closed the connection] 15:22 -!- Human_G33k [~HumanG33k@62.147.242.8] has joined ##hplusroadmap 15:29 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has quit [Ping timeout: 256 seconds] 15:30 -!- AgenttiX [agenttix@kapsi.fi] has joined ##hplusroadmap 15:33 -!- dongcarl [~dongcarl@unaffiliated/dongcarl] has joined ##hplusroadmap 15:50 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 256 seconds] 15:56 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 15:57 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 250 seconds] 16:04 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 16:04 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 16:04 -!- galambo_ [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 256 seconds] 16:11 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 256 seconds] 16:50 -!- filipepe [uid362247@gateway/web/irccloud.com/x-rorjcoyhykpjtopo] has joined ##hplusroadmap 16:56 -!- abetusk [~abe@68.175.128.91] has quit [Remote host closed the connection] 16:58 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has quit [Read error: Connection reset by peer] 16:58 -!- Codaraxis [~Codaraxis@ip68-5-175-208.oc.oc.cox.net] has joined ##hplusroadmap 17:36 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 17:36 -!- hehelleshin [~talinck@98.29.27.253] has joined ##hplusroadmap 17:40 -!- helleshin [~talinck@98.29.27.253] has quit [Ping timeout: 250 seconds] 18:21 -!- urkk [~urkk@116.128.239.188.dynamic.jazztel.es] has joined ##hplusroadmap 18:25 -!- urkk_ [~urkk@98.240.17.95.dynamic.jazztel.es] has quit [Ping timeout: 256 seconds] 18:38 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Quit: Leaving] 19:05 -!- abetusk [~abe@68.175.128.91] has joined ##hplusroadmap 19:31 < kanzure> hmph 19:32 < kanzure> the "human nature" crispr documentary is like 5x too slow 19:32 < kanzure> literally half of the shots are recorded in slowmo 19:57 -!- TC [~talinck@98.29.27.253] has joined ##hplusroadmap 19:58 -!- TC is now known as Guest95740 20:01 -!- hehelleshin [~talinck@98.29.27.253] has quit [Ping timeout: 256 seconds] 20:26 -!- Urchin [~urchin@unaffiliated/urchin] has joined ##hplusroadmap 20:43 -!- yashgaroth [~ffffffff@172.58.19.12] has quit [Quit: Leaving] 21:04 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has joined ##hplusroadmap 21:27 -!- galambo_ [~galambo@86.106.31.168] has joined ##hplusroadmap 21:30 -!- galambo [galambo@gateway/vpn/protonvpn/galambo] has quit [Ping timeout: 264 seconds] 21:56 < fltrz> jrayhawk, "full chain verification can be done with at most $100 worth of hardware literally anywhere on the surface of the Earth, public" << you mean it's broadcast from satellite? full chain? or how does that work? 21:57 < jrayhawk> Yeah, broadcast from satellite. 21:57 < jrayhawk> Full chain. 22:04 < fltrz> jrayhawk, any links on how to receive etc? also where are uplinks? in an internet censorship scenario, the few uplinks essentiallly become the miners over time. also what if the SWAT teams show up to shut down the uplink? 22:07 < jrayhawk> https://github.com/Blockstream/satellite https://blockstream.com/satellite/ five geosync satellites controlled from at least five independent ground stations around the earth, each cross-receiving from eachother to avoid partitioning. 22:19 -!- filipepe [uid362247@gateway/web/irccloud.com/x-rorjcoyhykpjtopo] has quit [Quit: Connection closed for inactivity] 22:30 -!- darsie [~kvirc@84-114-73-160.cable.dynamic.surfer.at] has joined ##hplusroadmap 22:43 -!- galambo_ [~galambo@86.106.31.168] has quit [Quit: Leaving] --- Log closed Thu Apr 02 00:00:40 2020