--- Log opened Thu May 28 00:00:33 2020
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07:10 < kanzure> "ZKboo: Faster zero-knowledge for boolean circuits" https://eprint.iacr.org/2016/163.pdf
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09:45 < fenn> .title https://phys.org/news/2020-05-espresso-presence-earth-nearest-star.html
09:45 < saxo> ESPRESSO confirms the presence of an Earth-sized planet around the nearest star (Update)
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14:55 < mrdata> time to plan a mission to visit there
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16:09 < kanzure> .title https://news.ycombinator.com/item?id=23334339
16:09 < saxo> The Vintage Beauty of Soviet Control Rooms (2018) | Hacker News
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16:39 < L29Ah> 19:45:03]<saxo> ESPRESSO confirms the presence of an Earth-sized planet around the nearest star (Update)
16:39 < L29Ah> i confirm it too
16:39 < L29Ah> it's tentatively called Earth now
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17:35 < kanzure> .wik south atlantic anomaly
17:35 < saxo> "The South Atlantic Anomaly (SAA) is an area where the Earth's inner Van Allen radiation belt comes closest to the Earth's surface, dipping down to an altitude of 200 kilometres (120 mi).  This leads to an increased flux of energetic particles in this region and exposes [...]" - https://en.wikipedia.org/wiki/South_Atlantic_Anomaly
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20:22 < kanzure> "A novel set of Cas9 fusion proteins to stimulate homologous recombination: Cas9-HRs" https://www.biorxiv.org/content/10.1101/2020.05.17.100677v1
20:22 < kanzure> "CRISPR/Cas9 has revolutionized genetic engineering, however, the inability to control double strand break (DSB) repair has severely limited both therapeutic and academic applications. Many attempts have been made to control DSB repair choice, however particularly in the case of larger edits, none have been able to bypass the rate-limiting step of Homologous Recombination (HR): long-range ...
20:22 < kanzure> ...5’ end resection. Here we describe a novel set of Cas9 fusions, Cas9-HRs, designed to bypass the rate-limiting step of HR repair by simultaneously coupling initial and long-range end resection. Cas9-HRs can increase the rate HR by 2-2.5 fold and decrease cellular toxicity by 2-4 fold compared to Cas9 in mammalian cells with minimal apparent editing site bias, thus making Cas9-HRs an ...
20:22 < kanzure> ...attractive option for applications demanding increased HDR rates for long inserts and/or reduced p53 pathway activation."
20:23 < kanzure> this was work done by a member of biocurious
20:24 < kanzure> http://www.crisp-hrtherapeutics.com/CRISP-HR_Therapeutic_Pipeline.html
20:40 < lsneff> .t https://arxiv.org/abs/2005.14165
20:40 < saxo> [2005.14165] Language Models are Few-Shot Learners
20:40 < lsneff> Paper about GPT-3 from openai. Very impressive results
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--- Log closed Fri May 29 00:00:36 2020