--- Log opened Tue Feb 02 00:00:33 2021 00:10 < L29Ah> a caffeine pill tastes as awful as coffee 00:23 -!- ottavio [~m0ttv@unaffiliated/m0ttv] has joined ##hplusroadmap 00:26 < archels> top tip: don't chew the non-chewable supplement pills 00:27 < archels> lsneff: caffeine is great, but one adapts insanely quickly to it, so it loses its efficacy within days 00:27 < L29Ah> it still tastes awful as it gets dissolved a lil while passing over the moist mucuous membranes 00:28 < L29Ah> yeah the tolerance buildup is really fast compared to mainstream ADHD things like amphetamine 00:31 -!- hellleshin [~talinck@cpe-174-103-159-2.cinci.res.rr.com] has joined ##hplusroadmap 00:35 -!- helleshin [~talinck@cpe-174-103-159-2.cinci.res.rr.com] has quit [Ping timeout: 264 seconds] 00:40 < lsneff> archels: I'll be careful there. How do you suggest I attempt to reduce my tolerance to it, to prevent efficacy loss as much as possible? 00:44 -!- hellleshin [~talinck@cpe-174-103-159-2.cinci.res.rr.com] has quit [Ping timeout: 240 seconds] 00:50 -!- helleshin [~talinck@cpe-174-103-159-2.cinci.res.rr.com] has joined ##hplusroadmap 00:58 -!- ShellcatZero1 [~ShellcatZ@174-29-98-61.hlrn.qwest.net] has joined ##hplusroadmap 00:59 -!- ShellcatZero [~ShellcatZ@75-166-68-216.hlrn.qwest.net] has quit [Ping timeout: 260 seconds] 01:08 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-jigcctvrxkbpgskj] has joined ##hplusroadmap 01:17 < archels> not much to be done afaik 01:24 < ottavio> I'm trying to reduce my dependence on caffeine with l-tyrosine. 01:26 < ottavio> Apparently it's got to do with dopamine and stuff. 01:28 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 272 seconds] 01:28 < ottavio> "Drink Coffee. Do stupid things faster!" 01:41 -!- darsie [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has joined ##hplusroadmap 02:26 < fenn> didn't bitcoin transcripts get moved to their own site that's not diyhpluswiki? 02:28 < fenn> re: chewing pills, once i really burned my throat because the coating had scratched off a little bit on an ibuprofen pill 02:28 < fenn> rather unexpected 02:31 < fenn> caffeine and piracetam go together well. the piracetam reduces the "cognitive noise" or tendency to bounce around between random thoughts, as well as physical tremors 02:31 < fenn> i haven't tried other racetams 02:45 -!- ShellcatZero1 [~ShellcatZ@174-29-98-61.hlrn.qwest.net] has quit [Ping timeout: 258 seconds] 02:48 -!- ShellcatZero [~ShellcatZ@174-29-127-2.hlrn.qwest.net] has joined ##hplusroadmap 02:52 -!- livestradamus [~quassel@unaffiliated/livestradamus] has quit [Quit: No Ping reply in 180 seconds.] 02:53 -!- livestradamus [~quassel@unaffiliated/livestradamus] has joined ##hplusroadmap 02:58 < lsneff> Caffeine seems to reduce "cognitive noise" for me, oddly enough. 03:09 < fenn> do you get tremors? 03:09 < fenn> or like a sub-threshold jittering feeling 03:17 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-jigcctvrxkbpgskj] has quit [Quit: Connection closed for inactivity] 03:23 < fenn> the tragedy is that springfield really did need a monorail, and instead of learning to be skeptical about government financing we've instead learned the wrong lesson that monorails are stupid and anyone who likes monorails is a bad guy 03:24 < fenn> #hashtagwheresmymonorail 03:28 < nmz787> monorail, monorail, monorail 03:47 < fenn> trending: "scientists have taught spinach to send emails" 03:47 < fenn> am I a joke to you? 03:49 < ottavio> fenn: I know some cabbage who can send emails. 04:04 -!- mgxm [~mgxm@unaffiliated/mgxm] has quit [Quit: ....] 04:06 -!- mgxm [~mgxm@unaffiliated/mgxm] has joined ##hplusroadmap 04:25 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 04:29 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 256 seconds] 05:49 < lsneff> fenn: I get jitters. 05:54 < docl> theanine can help with the jitters, I've heard 05:58 < docl> by the time I get a high enough dose to cause jitters I have other symptoms hard to describe but cognitive noise might be correct 05:59 < ottavio> docl: mildly. You need a 3:1 theanine/caffeine ratio to counteract jitters. 05:59 < docl> ahh, maybe that is why I didn't notice anything when I took it 06:11 < ottavio> docl: caffeine stimulates cortisol, which is not good, especially for performance/learning. It gives a good feeling though. It's an addictive drug. It's poor mans cocaine. 06:12 < lsneff> Maybe I should try to get diagnosed with ADHD, so I can get real stimulants. 06:12 < L29Ah> or try darknet 06:13 < lsneff> no 06:13 < L29Ah> adderall™ is insanely expensive in US 06:14 < ottavio> What do you need stimulants for? Is your life boring? 06:14 < lsneff> I looked at Vyvanse's insurance coverage, and it might come down to 30 bucks or so 06:14 < L29Ah> 30 bucks for what? 06:14 < lsneff> ottavio: to focus 06:14 < lsneff> for a month 06:14 < L29Ah> what's a month? 150mg? 06:15 < ottavio> lsneff: try fasting and ketogenic diet. 06:15 < ottavio> Brain works better on ketones. 06:15 < ottavio> and in a fasted state. 06:15 < L29Ah> ottavio: [citation needed] 06:15 < ottavio> Where do we start? 06:15 < lsneff> I already do intermittent fasting 06:15 < L29Ah> in my experience, i can't do complex things when i'm hungry 06:16 < docl> 30 bucks for vyvanse? really? 06:16 < ottavio> Start from here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194504/pdf/tacca00002-0213.pdf 06:16 < lsneff> Based on the manufacturer's website, could be wrong 06:16 < L29Ah> clinical and climatological association, huh 06:16 < docl> goodrx says 10x that https://www.goodrx.com/vyvanse 06:17 < ottavio> L29Ah: fasted doesn't mean hungry. 06:18 < lsneff> docl: I see that 06:18 < lsneff> criminal 06:19 < lsneff> docl: on that link: "Vyvanse is covered by most Medicare and insurance plans." 06:19 < L29Ah> 17:16:12] Start from here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194504/pdf/tacca00002-0213.pdf 06:19 < L29Ah> doesn't say anything about brain working "better" 06:19 < docl> I've been using nicotine gum (wouldn't dream of smoking), but it carries downsides. noticably my feet get cold where they didn't before. I think cognitive performance / executive function is better than baseline. amount of coffee I consume dropped a lot, but I am up to 40mg-60mg/day which seems high. 06:20 < ottavio> Have you already read 15 pages? Wow, then you need no stimulants, you're a genius. 06:20 < docl> ottavio: it's called ctrl-F, you learn these things when you have adhd :P 06:20 < L29Ah> great, then we're done i guess 06:21 < ottavio> ctrl-F is not a very intelligent way of learning. 06:22 < ottavio> Actually it's quite stupid. 06:22 < ottavio> No stimulants can compensate for stupidity. 06:22 < L29Ah> speed reading doesn't boil down to ctrl-f 06:22 < L29Ah> was i asking for stimulants? 06:23 < docl> depends on the context. sometimes you are just trying to find if a paper mentions a thing before you devote your expensive attention to it. 06:23 < ottavio> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194504/pdf/tacca00002-0213.pdf 06:23 < ottavio> goto page 8 06:23 < L29Ah> ottavio: and? 06:24 < ottavio> just do it, read it and use your brain. 06:24 < ottavio> where it says that ketones are better fuel than glucose. 06:24 < L29Ah> so? 06:24 < ottavio> Do you need to be spoon fed? 06:25 < L29Ah> it doesn't follow that brain works better while the human is in ketosis 06:25 < L29Ah> also rat heart is not a representative tissue for a human brain 06:26 < ottavio> It does, because the brain uses up 30% of daily calories. If you give the brain a better fuel, it will work better. It's all about metabolism. 06:26 < L29Ah> as heart muscles carry a special sort of mitochondria that don't occur anywhere else 06:26 < ottavio> You are grossly missing the point and not connecting the dots. I think this is the problem that no adderall can fix. 06:27 < L29Ah> will my laptop CPU work better if i plug 220V in it instead of 0.9V it runs on? it's more efficient power after all, and CPU consumes over 70% of my laptop power 06:28 < ottavio> Bad comparison. Stick to the point. The brain is not a CPU. 06:28 < L29Ah> brain is not heart as well. 06:28 < ottavio> You want to use your brain better, you need to start using first. 06:29 < ottavio> Making silly comparisons doesn't help. 06:29 < L29Ah> indeed. 06:29 < ottavio> Ketogenic diets are also being investigated to treat AD and dementia. 06:29 < ottavio> But they cost nothing and big pharma won't make a profit, so... 06:30 < ottavio> while adderall makes a profit... 06:30 < docl> if your brain is going down useless rabbit holes it doesn't matter how efficiently it does so. there's no scarcity of caloric energy. 06:32 < ottavio> if your brain is going down useless rabbit hole = what does it actually mean in scientific terms? This is poetic language. 06:35 < docl> attention deficit, not being able to focus in a constructive way on topics you choose to focus on 06:36 < ottavio> I can give anecdotal evidence of myself having increased my attention span and focus many fold by practising fasting and keto diets. 06:36 < docl> with stimulants in your system, you can more easily pick something and focus on it 06:37 < ottavio> adderall and co. might work, but it's just a shortcut. Cocaine also works, but is it healthy? 06:37 < ottavio> Stimulants only make you do stupid things faster. 06:40 < ottavio> You need to be careful when you stimulate the dopamine pathway. You want more dopamine but you also get more cortisol as side effect. 06:40 < ottavio> And cortisol impairs attention, so you're back to square one. 06:40 < docl> "Stimulants only make you do stupid things faster." now who's using poetic language? :) 06:41 < ottavio> No, it's a matter of fact. 06:42 < ottavio> Stimulants don't change your brain circuitry. They are a short term fix with side effects. 06:44 < ottavio> Also fasting increase attention span naturally. If you're "starving", you're more alert. 06:44 < ottavio> Note that I used "starving" paradoxically. 06:45 < ottavio> You're also more alert when you're angry. 06:45 < ottavio> Anger and hunger improve attention because of the fight/flight thingy. 06:46 < docl> fight or flight would tend to imply increased cortisol, no? 06:46 < ottavio> That reminds me I haven't eaten for 22 hours. 06:47 < fenn> ottavio: "caffeine is not good for performance" eh? caffeine is the only thing that gets most people out of bed and able to do anything at all 06:47 < fenn> anything > 0 06:47 < ottavio> docl: yes, that's why it's complicated. 06:47 < ottavio> fenn: yes, but is it healthy in the long run? 06:47 < fenn> yes, it turns out that caffeine extends lifespan 06:48 < docl> interesting that fasting is a stimulant. maybe a good thing to try on days when you aren't using caffeine e.g. to reduce tolerance 06:48 < fenn> most people who experience negative side effects from drugs are simply taking way too much of them 06:48 < ottavio> fenn: motivation is what gets people out of bed not caffeine. 06:48 < fenn> bullshit 06:48 < fenn> everybody is cheating with all the caffeine. without it the economy would crumble 06:48 < lsneff> that is pretty funny 06:48 < ottavio> Disclaimer: I am trying to quit caffeine myself. 06:48 < fenn> and by the way, cocaine powered the personal computer revolution 06:49 < fenn> just because something is illegal doesn't mean it's not effective 06:49 < ottavio> I drink 5-6 decafs a day. 06:49 < lsneff> I've avoided caffeine until now because I didn't want to build dependency 06:49 < fenn> just take less of it, sheesh 06:49 < ottavio> lsneff: good stuff. I am taking tyrosine. 06:50 < fenn> ottavio: try phenylalanine. it's less anxiety inducing 06:50 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-uddpmaxefepdqdmp] has joined ##hplusroadmap 06:50 < ottavio> fenn: yes, but it's more expensive. 06:50 < fenn> (than tyrosine) 06:50 < lsneff> I just noticed lots of people around me getting headaches and feeling awful when they didn't get coffee. 06:50 < lsneff> Didn't want that 06:50 < fenn> but really, who cares about the relative price when it's like $0.05/day 06:51 < ottavio> fenn: I need to order it from outside the UK and it would cost me a fortune in extra charges. 06:51 < ottavio> Plus I want to avoid Hermes. Most online sellers use Hermes, which is pretty bad. 06:52 < ottavio> Thinking of starting my supplement business, though. 06:52 * L29Ah is suspicious about people suggesting essential amino acid supplementation 06:52 < fenn> i just looked up the price and it's literally $0.05 per pill (500mg) from swanson vitamins 06:52 < lsneff> fenn: do you have diagnosed adhd? 06:52 < fenn> mp 06:52 < fenn> no* 06:53 < L29Ah> if it really works, maybe you should consider consuming a complete protein instead, as it's cheaper and healthier than that specific amino acid that you happened to identify your deficiency with? 06:53 < fenn> L29Ah: with single amino acid supplementation your brain absorbs more of that one amino acid when insulin causes amino acids to be driven across the blood brain barrier 06:53 < fenn> taking a complete protein completely defeats the point 06:54 < fenn> the whole idea is to have an unbalanced ratio at some time 06:54 < fenn> our goal here is to modify neurotransmitter levels 06:54 < ottavio> fenn: this is true especially of tryptophan. 06:55 < ottavio> You also need p5p piridoxal phospate. 06:55 * L29Ah got into the fad and forced 5g of tryptophan down his throat, it was hard but i did it, yet observed no effects 06:55 < fenn> good for you 06:55 < ottavio> and probably also magnesium. 07:26 < docl> what's everyone's favorite cheap protein? I've been using cottage cheese lately. some tuna, but I now live with 2 cats and they get ideas when I open a can. 07:26 < L29Ah> docl: i mostly consume oats and soy textured protein 07:27 < L29Ah> oat protein isn't as nicely balanced as soy but cheaper 07:28 < L29Ah> consider eating your cats, they have some protein + you save your tuna from vermin 07:28 < docl> lol good idea 07:28 < lsneff> Oats and textured protein sounds pretty boring 07:29 < ottavio> docl: meat, mature cheese. I stopped eating fish because of plastic pollution. 07:29 < lsneff> I eat rarely as is, it's difficult to convince myself to eat food that isn't interesting 07:30 < ottavio> I find any food interesting. 07:30 < L29Ah> lsneff: i tend to tell apart nutrition and entertainment, but you can grab some garlic/capsaicin/glutamate/aspartame to make it funnier 07:30 < docl> for those of us who overeat easily bland can be good, but for a hard gainer it's not necessarily the best strategy 07:30 < docl> nutritional yeast flakes make cottage cheese bettter (to my taste) 07:31 < docl> basically you have to mix strong tasting stuff with bland stuff for it to taste all right 07:32 < docl> adding shredded cheddar cheese to cottage cheese makes it taste good, but I worry about calorie balance + incentive to overeat 07:33 < L29Ah> i consider consuming orexin agonists for some time to get more muscle (and hunger for it), but i'm not happy about injecting substances with questionable origins; otherwise my BMI is rock stable for my entire life regardless of my food 07:34 -!- spaceangel [~spaceange@ip-94-112-205-34.net.upcbroadband.cz] has joined ##hplusroadmap 07:34 < docl> nice! 07:35 < docl> part of why I like nicotine is appetite control. caffeine increases my appetite 07:47 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:7cb3:db53:9dbd:ef16] has joined ##hplusroadmap 07:53 < fenn> oats, canned salmon, whey protein 07:53 < fenn> i have a theory that large quantities of nutritional yeast can induce psychosis or a delusional break of some sort 07:54 < lsneff> this is seriously what you guys eat? 07:54 < fenn> or possibly habitually eating large amounts of nutritional yeast and suddenly stopping 07:54 -!- ottavio_ [~m0ttv@unaffiliated/m0ttv] has joined ##hplusroadmap 07:54 < L29Ah> lsneff: i mostly eat https://github.com/l29ah/muesli 07:54 -!- ottavio [~m0ttv@unaffiliated/m0ttv] has quit [Ping timeout: 240 seconds] 07:55 < fenn> he asked for cheap protein. it's what i use for cheap protein, and yes i do eat what i said 07:55 < L29Ah> damn the photo hosting is dead, should've put the photos in the repo maybe 07:55 < fenn> i don't like soy because it causes farts/diarrhea 07:56 < L29Ah> worksforme 07:56 < fenn> soy contains trypsin inhibitors which interfere with digestion allowing bacteria to grow 07:56 < L29Ah> but yeah soy or gluten intolerance are common-ish 07:56 < fenn> if you are combining it with yogurt then maybe it the lactic acid suppresses that 07:56 < fenn> or some other wacky microbiome shenanigans 07:56 < L29Ah> afaik trypsin inhibitors aren't as abundant in TVP as in whole soy 07:57 < lsneff> L29Ah: how much does that end up costing? 07:57 < L29Ah> > It consumes about $1 and 15mins per day 07:57 < lsneff> sorry, illiterate 07:59 < fenn> i found some graphical circle plots for amino acid balance of a few different types of protein, but haven't been able to find a source with lots of data or a consistent way of comparing them without doing a lot of tedious data entry and coding just to get them in the same format 08:00 < fenn> for some reason this is not in the USDA nutrition database? it's a strange omission 08:01 < lsneff> L29Ah: and you feel healthy mostly just eating that? 08:01 < fenn> lsneff i'm curious what sort of answer you were expecting 08:01 < L29Ah> idk, i don't have health receptors in my body 08:01 < lsneff> I'm curious as well 08:02 < lsneff> that's why I asked 08:02 * fenn injects L29Ah with health receptor growth stimulant 08:02 < L29Ah> fenn: USDA database has essential amino acids for the most common stuff 08:03 < fenn> link? search keywords? 08:04 < L29Ah> wut 08:04 < L29Ah> search your shit 08:04 < L29Ah> click "list every nutrient" 08:04 < fenn> fuck you gimme the keywordssss 08:04 < L29Ah> look down 08:04 < L29Ah> keywords for what? for oats? 08:04 < L29Ah> it's "oats" 08:04 < fenn> for what the hell they call the amino acid composition 08:04 < fenn> or whatever interface you are using 08:05 < fenn> i am search-challenged these days 08:05 < fenn> not by choice or mental inability 08:05 < lsneff> searchly-disabled 08:05 < L29Ah> ok their webshit search doesn't work at all for me today 08:06 < L29Ah> https://fdc.nal.usda.gov/fdc-app.html used to work 08:06 < fenn> does grep and tracker mean i'm searchly-different 08:06 < lsneff> differently-searched 08:07 < fenn> or how about at the very least, a specific food that you have seen amino acid balance data for, from the USDA 08:09 < L29Ah> fenn: defatted soy flour 08:10 < fenn> ok see i would not have thought to look for that, like, ever 08:10 < fenn> and i do see the amino acid data there, thanks 08:14 < L29Ah> you asked for a specific one; i also got it for oats, buckwheat and whatnot, but the database is full of tons of shitty entries for those to confuse you 08:16 < fenn> ok i don't know what i was doing wrong before as suddenly it's easily visible in my database search tool (nut-nutrition) 08:18 < L29Ah> wats "nut-nutrition"? 08:18 < fenn> just some terminal program that comes with a copy of the USDA database 08:18 < L29Ah> if you're grep-enabled, tell me what do i download so i can grep shit too 08:18 < L29Ah> as their web interface gradually gets worse with time 08:22 < fenn> i guess nut-nutrition has to download the db from somewhere 08:22 < fenn> the db is 5.7MB and nut is 144k 08:23 < fenn> and yes it has all the campbells soup and taco bell crap 08:23 < fenn> whale snouts and dried chives 08:24 < docl> hmm. spirulina in bulk is $11/kg, maybe I should get some 08:24 < fenn> i've gradually come to the opinion that spirulina is worse than nothing 08:24 < fenn> chlorella might be good though 08:24 < fenn> nothing meaning no intervention 08:25 < docl> what's the downside of spirulina? 08:25 < fenn> maybe mercury toxicity? 08:25 < fenn> it tastes like paint? 08:25 < fenn> there might be a wide range in quality too 08:25 < fenn> just judging by taste 08:25 < docl> it's not tasty, for sure 08:25 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 08:26 < fenn> well the "organic" tablets i have taste good, but the generic powder i have doesn't 08:30 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 246 seconds] 08:31 < fenn> docl: i will caution that whey protein is insulinogenic so if you chug a bunch of it with your soda it will cause you to put on fat. bodybuilders like it because it causes you to put on weight, but the fat/muscle is determined by whether you have recently exercised 08:32 < fenn> because of the relatively high valine/isoleucine content iirc 08:34 < fenn> "Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP)" 08:34 < fenn> .title http://pubmed.ncbi.nlm.nih.gov/22647249/ 08:34 < saxo> The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells - PubMed 08:38 < docl> good to know! 08:40 < fenn> really the paper should be using another protein as the control, not glucose 09:16 < lsneff> any of you know of any research on building small circuits/machines with STMs? 09:34 -!- thahxa [~thahxa@lnsm1-toronto10-142-116-155-169.internet.virginmobile.ca] has joined ##hplusroadmap 09:40 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 10:21 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 264 seconds] 11:13 < L29Ah> 19:25:25] maybe mercury toxicity? 11:13 < L29Ah> why would anyone add mercury to their spirulina pools? 11:17 < fenn> well my theory is that it binds mercury already present in the body and makes it more bioavailable 11:17 < fenn> feel free to disregard 11:21 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 11:23 < archels> haha, Anders Sandberg suggests to use GPT-3 to write grant applications 11:29 < mjr[m]> lol 11:29 < thahxa> maybe you can use it to write cover letters 11:36 < superkuh> When I was in middle school I used one of Kurzweil's poetry generation bots to do an english assignment. 11:37 < superkuh> The tech has come a long way. 11:50 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 258 seconds] 11:57 < fenn> maybe spacex starship SN9 launch in half an hour 11:57 < fenn> with large error bars 12:00 < L29Ah> russian opposition leader was launched into prison today :< 12:00 < fenn> didn't they arrest him upon landing at the airport? 12:01 < L29Ah> they did, and today was the court hearing 12:01 < fenn> what were the charges? 12:02 < kanzure> refusing to be poisoned to death 12:02 < kanzure> let's stick to spacex though 12:02 < L29Ah> fenn: https://en.wikipedia.org/wiki/Alexei_Navalny#Yves_Rocher_case_and_home_arrest 12:02 < L29Ah> okay 12:10 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 12:14 < fenn> T-11m ish 12:15 < L29Ah> huh, no stream in youtube!? 12:17 < fenn> apparently not 12:18 < fenn> i'm watching nasaspaceflight who generally know what they're talking about http://youtu.be/wfHqbahPKpY 12:18 < abetusk> fenn, you were working on an oligonucleotide synthesis machine at one point, right? 12:18 < fenn> yes, ask me about that later plz 12:19 < abetusk> 6+ hours ok? 12:19 < fenn> might not be awake then 12:19 -!- ottavio_ [~m0ttv@unaffiliated/m0ttv] has quit [Quit: Leaving] 12:19 < abetusk> 2+ hours? 12:19 < fenn> basically the hackerspace/lab didn't want to/couldn't install a fume hood 12:19 < fenn> and we needed to work with acetonitrile 12:20 < thahxa> isnt acetonitrile not that bad all things considered? 12:20 < fenn> i couldn't get safety data on the DNA precursor chemicals 12:20 < thahxa> gimmie a sec 12:21 < abetusk> Did you buy a used one that you were going to refurbish? How far did you get, barring the fume hood installation? 12:21 < thahxa> cuz you can normally get sds's from sigma aldrich 12:21 < fenn> anyway abetusk if you want to read about it look for "POSAM" 12:21 < fenn> which we were simply going to replicate 12:21 < thahxa> oh yea posam i read that paper 12:21 < abetusk> fenn, thanks 12:21 < fenn> http://diyhpl.us/wiki/dna/synthesis/notes/ 12:22 < fenn> ok T-4 minutes 12:22 < thahxa> wrt to the safety data on the dna precursors you can grab the sds's from sigma cant ya? 12:22 * fenn sticks fingers in ears nyaaa 12:22 < fenn> .title https://www.youtube.com/watch?v=_zZ7fIkpBgs 12:22 < saxo> Starship | SN9 | High-Altitude Flight Test - YouTube 12:23 < fenn> 2 minutes 12:23 < fenn> cutting it a little close there guys! 12:25 < L29Ah> brrr 12:27 < thahxa> haha rocket go brrr 12:34 < fenn> that's not the landing i wanted! 12:34 < kanzure> i want a refund 12:35 < kanzure> abetusk: thahxa: nmz787 also reverse engineered parts of the ABI 394 one. 12:36 < thahxa> pretty interesting 12:37 < thahxa> actually thats pretty cool 12:38 < kanzure> https://diyhpl.us/~bryan/papers2/DNA/abi391/ 12:38 < kanzure> 391, not 394. my mistake. 12:39 < thahxa> fenn: have you looked into using alternate solvents instead of MeCN btw if you can't use it (although i don't see why not) 12:40 < thahxa> cuz i read somewhere stuff like propylene glycol works-ish for this application 12:41 < fenn> no i don't know enough about the chemistry 12:41 < abetusk> kanzure, you have some notes on microfluidic oligonucleotide synthesis...any reason not to pursue that method? 12:42 < kanzure> https://diyhpl.us/~bryan/papers2/microfluidics/ 12:42 < kanzure> https://diyhpl.us/~bryan/papers2/microfluidics/synthesis/ 12:42 < kanzure> https://diyhpl.us/~bryan/papers2/DNA/ 12:42 < kanzure> have fun huffing 1-methylimidazole 12:43 < kanzure> there has been no demonstration of high throughput dna synthesis in microfluidic setups- if your goal isn't high throughput then maybe it's ok 12:44 < thahxa> ah ok 12:44 < kanzure> most of the large-scale synthesis companies are using the semiconductor wafer approach 12:44 < thahxa> because some of the traditional reagents that are used arent super condusive to good health and intactness of fingers 12:44 < thahxa> 1h-tetrazole for example 12:44 < kanzure> nah i don't care about that 12:45 < thahxa> about what? 12:45 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-snrrnmpcbihejptp] has joined ##hplusroadmap 12:46 < kanzure> your health 12:46 < thahxa> ah 12:46 < thahxa> theres other reasons not to use pure tetrazole too 12:46 < thahxa> the whole "its a primary explosive" is just the biggest one 12:46 < kanzure> use standard protection procedures and get on with it 12:47 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 240 seconds] 12:47 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 12:48 < thahxa> tetrazole kinda sucks for activation anyways from what ive read 12:48 < thahxa> and you can just buy dci or somethin elsewhere 12:50 < thahxa> either way kanzure how far along did the reverse engineering bit go wrt being able to replicate it? 13:02 < thahxa> b/c on the website i see a good amount of stuff documenting the device but not much on replication efforts 13:03 -!- jcorgan [~jcorgan@unaffiliated/jcorgan] has joined ##hplusroadmap 13:28 < fenn> we didn't build any hardware 13:45 < docl> I wonder if microfluidic spiroligomer synthesis is a useful idea 13:50 < kanzure> https://www.sciencemag.org/news/2019/03/researchers-embrace-radical-idea-engineering-coral-cope-climate-change 13:50 < kanzure> "radical idea of actually using genetic engineering!" 13:50 < kanzure> morons 13:51 < docl> "but won't that affect the environment?" 13:51 < kanzure> you should also engineer the environment while you're at it! 13:52 * L29Ah engineers his air humidifier: https://tinystash.undef.im/il/4v79rH872uMEMdGWnSQTuuMGwCBJmSPLJAic3vVeKa4RiJgADzvTjZ7oDqQ6wbzx8ptS3ZH4EosNJtGgX9if4D9P 13:52 < L29Ah> meanwhile ultrasound is surprisingly and hideously painful 13:52 < kanzure> turn up the energy 14:37 -!- saurik [saurik@carrier.saurik.com] has joined ##hplusroadmap 14:38 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 258 seconds] 14:40 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 14:45 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 265 seconds] 14:48 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 15:10 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Ping timeout: 258 seconds] 15:15 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-snrrnmpcbihejptp] has quit [Quit: Connection closed for inactivity] 15:21 < fltrz> so I downloaded the ~180GB JSON corpus of semantic scholar article metadata, does anyone know if theres any interesting project that makes use of it? 15:22 < L29Ah> no, but i can suggest you some even bigger stuff to download 15:22 < fltrz> :) 15:23 < fltrz> always open, but I can't handle libgen nor scihub, unless its physical media 15:23 < L29Ah> you can host chunks of libgen 15:23 < L29Ah> also GSM cracking rainbow tables should be about a couple TBs 15:23 < fltrz> L29Ah, theres topical chunks or just chunks? 15:24 < L29Ah> just chunks 15:24 < fltrz> was thinking if we could use retraction watch & citation graph / author data to more efficiently hunt bullshit 15:25 < L29Ah> and there's no service that checks which ones should you host to have the biggest availability impact afaik :( 15:35 < thahxa> its already been done iirc but you can map the social network of citations 15:35 < thahxa> and see where the deeply connected nodes of the small world you'd (probably) get out are 15:40 < kanzure> the textonly libgen dump is pretty small 15:45 -!- sanehatter [sanehatter@gateway/vpn/mullvad/sanehatter] has joined ##hplusroadmap 15:46 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has joined ##hplusroadmap 16:02 -!- realisation [~realisati@cpe-98-150-146-3.hawaii.res.rr.com] has quit [Quit: Lost terminal] 16:13 -!- spaceangel [~spaceange@ip-94-112-205-34.net.upcbroadband.cz] has quit [Remote host closed the connection] 16:14 -!- Urchin[emacs] [~user@unaffiliated/urchin] has quit [Ping timeout: 240 seconds] 16:56 -!- Urchin[emacs] [~user@unaffiliated/urchin] has joined ##hplusroadmap 17:11 -!- preview [~quassel@2407:7000:8423:b79:29e:ecd2:bbd0:8cfd] has quit [Ping timeout: 264 seconds] 17:14 -!- preview [~quassel@2407:7000:8423:b79:29e:ecd2:bbd0:8cfd] has joined ##hplusroadmap 17:25 -!- CryptoDavid [uid14990@gateway/web/irccloud.com/x-uddpmaxefepdqdmp] has quit [Quit: Connection closed for inactivity] 18:05 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:7cb3:db53:9dbd:ef16] has quit [Quit: Leaving] 19:08 < fenn> https://www.kice.com/blog-of-kice/origin-of-the-kice-chickenveyor/ pneumatic bird delivery 19:13 < kanzure> i have many questions 19:14 < fenn> is one of them about getting your house connected to the chicken delivery network? 19:17 < kanzure> does this work for all avian lifeforms? 19:18 < kanzure> like what about strategic pneumatic ostrich delivery 19:19 < kanzure> and how frequently is someone transporting a chicken that they need to automate this? 19:30 < fenn> do you want to move millions of chickens or do you wanna be a crybaby 19:46 -!- darsie [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 265 seconds] 19:52 < lsneff> is this the chicken version of the soup tube? 20:00 < fenn> how closed-minded to think that cans only contain soup 20:01 < fenn> this is the liberating canless chicken public transportation system 20:01 < fenn> minimal bruising! 20:07 -!- thahxa [~thahxa@lnsm1-toronto10-142-116-155-169.internet.virginmobile.ca] has quit [Remote host closed the connection] 20:07 < lsneff> for context on the soup tube: https://twitter.com/redditships/status/1280975449485651969 20:10 < fenn> "obviously, the idea is completely insane" 20:11 -!- thahxa [~thahxa@lnsm1-toronto10-142-116-155-169.internet.virginmobile.ca] has joined ##hplusroadmap 20:13 < fenn> this is amazing, visionary even https://nitter.net/pic/media%2FEcbwYxCWAAEHiYJ.jpg:orig 20:14 < fenn> nothing says modern like "liquid slurry silo" 20:39 -!- yonkunas [uid403824@gateway/web/irccloud.com/x-jyhgmybeppgvumpo] has quit [Quit: Connection closed for inactivity] 20:42 < lsneff> that's beautiful 21:43 < thahxa> that soup tube post fucking broke me 22:02 < fltrz> kanzure, I think we talked about text only before, but it wasn't libgen, or it was only fiction or something --- Log closed Wed Feb 03 00:00:34 2021