--- Log opened Mon Feb 08 00:00:23 2021 00:37 -!- HumanG33k [~HumanG33k@82-64-99-84.subs.proxad.net] has quit [Read error: Connection reset by peer] 00:37 -!- HumanG33k [~HumanG33k@82-64-99-84.subs.proxad.net] has joined ##hplusroadmap 02:15 -!- darsie [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has joined ##hplusroadmap 02:33 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-prdqvovryojjquds] has joined ##hplusroadmap 03:09 -!- srk [~sorki@gateway/tor-sasl/sorki] has quit [Remote host closed the connection] 03:10 -!- srk [~sorki@gateway/tor-sasl/sorki] has joined ##hplusroadmap 04:08 -!- ccdle12 [955adef3@243.222.90.149.rev.vodafone.pt] has joined ##hplusroadmap 04:39 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Ping timeout: 264 seconds] 04:46 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 04:53 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-prdqvovryojjquds] has quit [Quit: Connection closed for inactivity] 04:54 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:e8fa:1666:b10:730c] has joined ##hplusroadmap 04:56 < docl> lsneff: nanotech is freaking important. lots of glory to be had there. but if you want to be a star, you need to focus on a thing nobody else is doing... lots of subcategories of nano fit this profile 04:57 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Remote host closed the connection] 04:57 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 04:59 < docl> that said I definitely relate to not being able to pick one thing to focus on. definitely easier to find a way to get paid to sling code. 05:03 < docl> am currently working for a retail giant. lets me get paid to grind C/C++ programming skill, but super boring and not something I will ever be famous for or make much of a difference for the world. 05:10 < TMA> docl: just for my own curiosity, how old are you? [I am trying to figure out whether I burned out sooner or later than is usual.] 05:11 < docl> 37 05:12 < docl> just got my associate's in comp sci a couple years ago 05:12 < apotheon> "grind $foo programming skill" seems familiar 05:13 < apotheon> (from some of my own employment life) 05:15 < docl> yep... I had a call center job for 9 years, but luckily was able to grind some SQL during that time and put in a bit of open source stuff otherwise it would be unlikely I'd have got this job without a bachelor's. 05:21 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Remote host closed the connection] 05:21 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 05:25 -!- sanehatter [~sanehatte@141.98.255.152] has joined ##hplusroadmap 05:27 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-sykpcfswbezsatgb] has quit [Write error: Connection reset by peer] 05:27 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-ecnevpgerhrrvsyo] has quit [Read error: Connection reset by peer] 05:27 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-blkvuxnortytbkss] has quit [Read error: Connection reset by peer] 05:27 -!- acertain [sid470584@gateway/web/irccloud.com/x-yywtldtivzbefsrr] has quit [Write error: Connection reset by peer] 05:27 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-excmasexioyozrmq] has quit [Read error: Connection reset by peer] 05:27 -!- strages [sid11297@gateway/web/irccloud.com/x-obkimwnqzzplxpxe] has quit [Read error: Connection reset by peer] 05:27 -!- yonkunas [uid403824@gateway/web/irccloud.com/x-iloxfcplvigrwvgj] has quit [Read error: Connection reset by peer] 05:27 -!- redlegion [sid429547@gateway/web/irccloud.com/x-ebfnmtmgffmnnvcu] has quit [Read error: Connection reset by peer] 05:27 -!- potatope [sid139423@gateway/web/irccloud.com/x-uoelynnlmkbgzkuj] has quit [Read error: Connection reset by peer] 05:27 -!- wallet42____ [sid154231@gateway/web/irccloud.com/x-lqwrexozzfjzdwgt] has quit [Read error: Connection reset by peer] 05:27 -!- lsneff [sid265665@gateway/web/irccloud.com/x-eywhyzgpnqrxtoev] has quit [Read error: Connection reset by peer] 05:28 -!- potatope [sid139423@gateway/web/irccloud.com/x-fjolytkmddrapamw] has joined ##hplusroadmap 05:28 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-tirpenzomsqmwbbp] has joined ##hplusroadmap 05:28 -!- strages [sid11297@gateway/web/irccloud.com/x-poztwizgrcjkvbrp] has joined ##hplusroadmap 05:29 -!- yonkunas [uid403824@gateway/web/irccloud.com/x-uijcpotwjshunnbk] has joined ##hplusroadmap 05:29 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Remote host closed the connection] 05:30 -!- redlegion [sid429547@gateway/web/irccloud.com/x-onlavtagonmekvro] has joined ##hplusroadmap 05:30 -!- wallet42____ [sid154231@gateway/web/irccloud.com/x-nrnjyscfuzfhfxil] has joined ##hplusroadmap 05:30 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 05:31 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-whkjlfpexlylznca] has joined ##hplusroadmap 05:32 < docl> .title https://en.wikipedia.org/wiki/Microfluidics 05:32 < saxo> "Microfluidics refers to the behaviour, precise control, and manipulation of fluids that are geometrically constrained to a small scale (typically sub-millimeter) at which surface forces dominate volumetric forces." - https://en.wikipedia.org/wiki/Microfluidics 05:33 < docl> this appears to be a productive field to study 05:34 -!- lsneff [sid265665@gateway/web/irccloud.com/x-ietahgezeydxjsbp] has joined ##hplusroadmap 05:45 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-uotvgzdhuchqqgwc] has joined ##hplusroadmap 05:45 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-izjqtpicggwevlyq] has joined ##hplusroadmap 05:49 -!- acertain [sid470584@gateway/web/irccloud.com/x-qcnlnbxhzvnipgcz] has joined ##hplusroadmap 06:05 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Ping timeout: 246 seconds] 06:09 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 06:13 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Remote host closed the connection] 06:17 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 06:19 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Remote host closed the connection] 06:19 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has joined ##hplusroadmap 07:18 < docl> .title https://hackaday.com/2017/02/28/microfluidic-lego-bricks/ 07:18 < saxo> Microfluidic LEGO Bricks | Hackaday 07:23 -!- ccdle12 [955adef3@243.222.90.149.rev.vodafone.pt] has quit [Quit: Ping timeout (120 seconds)] 08:55 -!- HEx1 [~HEx@hexwab.plus.com] has quit [Ping timeout: 264 seconds] 09:27 -!- grimler32 [~grimler67@pool-108-49-215-20.bstnma.fios.verizon.net] has quit [Quit: Leaving] 09:34 < docl> .title https://www.xprize.org/prizes/elonmusk 09:34 < saxo> Carbon Removal At Gigaton Scale | XPRIZE Foundation 09:37 -!- thahxa [~thahxa@vlnsm4-toronto63-142-122-136-238.internet.virginmobile.ca] has joined ##hplusroadmap 09:56 -!- spaceangel [~spaceange@ip-94-112-205-34.net.upcbroadband.cz] has joined ##hplusroadmap 10:25 -!- wallet42____ [sid154231@gateway/web/irccloud.com/x-nrnjyscfuzfhfxil] has quit [Read error: Connection reset by peer] 10:25 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-tirpenzomsqmwbbp] has quit [Read error: Connection reset by peer] 10:26 -!- wallet42____ [sid154231@gateway/web/irccloud.com/x-jujxerrvfrbgtepo] has joined ##hplusroadmap 10:26 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-iohsmtwfjecwgeft] has joined ##hplusroadmap 10:32 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-vpyjlfpqwjkjebvf] has joined ##hplusroadmap 10:41 < docl> hmm. inkjet printers are just consumer grade microfluidic distributors. not suitable for some reagents that can't handle atmospheric exposure, but I wonder if they are useful for spiroligomer synthesis 10:45 < docl> .wik Spiroligomer 10:45 < saxo> "Spiroligomers (also known as bis-peptides) are synthetic oligomers made by coupling pairs of bis-amino acids into a fused ring system." - https://en.wikipedia.org/wiki/Spiroligomer 10:45 < docl> "Spiroligomers are synthesized in a step-wise approach by adding a single bis-amino acid at each stage of the synthesis. This stepwise elongation allows for complete control of the stereochemistry, as any bis-amino acid can be incorporated to allow for elongation; or any mono-amino acid can be added to terminate a chain. This can be accomplished using either solution-phase or solid-phase reactions." 10:47 < docl> so maybe that means you can load up some cartridges with bis-amino acids and print them as a "color photo" to get tiny amounts of custom built spiroligomers? use multiple passes with different cartridge sets? 11:06 -!- jcorgan [~jcorgan@unaffiliated/jcorgan] has left ##hplusroadmap [] 11:07 -!- jcorgan [~jcorgan@unaffiliated/jcorgan] has joined ##hplusroadmap 11:24 -!- nmz787_ [~nmz787@bryan.fairlystable.org] has joined ##hplusroadmap 11:25 -!- nmz787_ [~nmz787@bryan.fairlystable.org] has quit [Changing host] 11:25 -!- nmz787_ [~nmz787@unaffiliated/nmz787] has joined ##hplusroadmap 11:30 -!- srk [~sorki@gateway/tor-sasl/sorki] has quit [Remote host closed the connection] 11:31 -!- srk [~sorki@gateway/tor-sasl/sorki] has joined ##hplusroadmap 11:31 -!- HEx1 [~HEx@hexwab.plus.com] has joined ##hplusroadmap 12:30 < fenn> nobody is doing nanotech :( 12:36 < docl> schafmeister is 12:46 -!- ccdle12 [955adef3@149.90.222.243] has joined ##hplusroadmap 12:55 < nmz787_> "no one" lol 12:56 < docl> Moheimani is also doing some APM stuff https://utdallas.edu/news/science-technology/2-4-million-grant-supports-research-to-improve-atomically-precise-manufacturing/ 12:56 < nmz787_> I just got a project from design and debug through mass manufacturing for trillions of buddhist mantras for next-generation nanotech prayer wheels 12:57 < docl> oh wow 12:57 < nmz787_> https://www.norsam.com/products/buddhist-nano-film/ 12:58 < docl> > Norsam provides custom mantras on nano film for prayer wheels and archival preservation and spiritual applications utilizing electron and ion beam technologies and state of the art duplication methods. Rolls of nano film can be supplied in any length and height. For instance, a 2,000 ft roll of nano film 5â€" high can hold approximately one trillion mantras. 12:59 < nmz787_> (I realize this is not the nanotech fenn is likely talking about... but it's definitely good learning for me to get to the "real" stuff) 13:03 < docl> spamming the gods with more efficient prayers, well I guess there are less accurate descriptions of nanotech out there 13:05 < superkuh> https://en.wikipedia.org/wiki/The_Nine_Billion_Names_of_God 13:07 < docl> now I know where unsong got the idea 14:05 -!- L29Ah [~L29Ah@unaffiliated/l29ah] has quit [Write error: Connection reset by peer] 14:16 -!- L29Ah [~L29Ah@unaffiliated/l29ah] has joined ##hplusroadmap 14:34 < juri_> there needs to be more bioprinting. it's been a while since i saw anything interesting out of that. 14:39 -!- join_cordblood [~join_cord@135-23-248-163.cpe.pppoe.ca] has quit [Quit: leaving] 14:45 -!- L29Ah [~L29Ah@unaffiliated/l29ah] has quit [Ping timeout: 240 seconds] 14:46 -!- L29Ah [~L29Ah@unaffiliated/l29ah] has joined ##hplusroadmap 15:04 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-uotvgzdhuchqqgwc] has quit [Read error: Connection reset by peer] 15:04 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-whkjlfpexlylznca] has quit [Read error: Connection reset by peer] 15:04 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-izjqtpicggwevlyq] has quit [Read error: Connection reset by peer] 15:04 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-vacykevlcltjliir] has joined ##hplusroadmap 15:05 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-vrfvyczcignesbni] has joined ##hplusroadmap 15:05 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-feigsoxbyvjberaf] has joined ##hplusroadmap 15:05 < fenn> when i say nanotech i mean the original intended meaning, not the fake "anything with dimensions measured in nanometers" crowd that jumped on the wagon and broke it 15:06 < fenn> reza moheimani is developing MEMS actuators for scanning probe tooltips, which, while highly relevant, is still not actually doing the thing itself 15:06 < fenn> first you get good, then you scale it up 15:07 < fenn> starting out by parallelizing something is backwards 15:07 < L29Ah> s/nanotech/complex diamondoids/? 15:07 < fenn> atomically precise manufacturing 15:08 < fenn> there COULD be a route through biotech, but i haven't seen anything beyond some amateurish DNA origami stuff 15:08 < fenn> most protein engineering is focused on the biological applications 15:08 < L29Ah> x-ray photolitography 15:09 < fenn> x-ray is far too broad a term 15:09 < fenn> i'm also not convinced that it would be atomically precise 15:10 < fenn> there's also the problem of making something useful. you can make a slab of atoms that's exactly 1000 atoms thick, but that's sort of missing the point 15:10 < L29Ah> it is not, as you have alignment problems, but it is probably the best bet at macroscale atomically precise manufacturing 15:10 < fenn> well whatever, this is rapidly going off into fake nanotech territory 15:10 < fenn> i'm talking about the vision in engines of creation, nanosystems, etc 15:18 < docl> spiroligomers are real molecular machines. not the same category as eutactic environment stuff. I was discussing this with lsneff here the other day 15:19 < docl> the machine parts have to be made of atoms, which is tricky because atoms tend to wriggle around to the lowest energy structure 15:20 < docl> so you need very low temperatures for rigid nanosystems to work 15:21 < docl> spiroligomers are related to proteins, but not really the same thing. proteins are floppy things designed to fold, which is hard to predict, and they have lots of single bonds which make them delicate by comparison 15:21 < fenn> spiroligomers are not floppy? 15:24 < docl> no, as I understand it they have double bonds so they are more stable than proteins 15:25 < fenn> so for making complex shapes you must insert a hinge unit at each corner? 15:26 < docl> drmeister says they are using spiroligomers as scaffolds with other molecules mounted on them as tools 15:26 < L29Ah> fenn: i wonder what do you personally want atomically precise manufacturing for 15:26 < fenn> go read the books 15:26 < docl> I should probably rewatch https://www.youtube.com/watch?v=mbdXeRBbgDM 15:26 < fenn> .title 15:26 < saxo> 2018 LLVM Developers’ Meeting: C. Schafmeister “Lessons Learned Implementing Common Lisp with LLVM” - YouTube 15:27 < L29Ah> mainly is it about feature size or about the chemical interaction capabilities 15:27 < fenn> neither really. it's about rates of material production and the economics of capital 15:28 < fenn> basically everything would become very inexpensive 15:28 < L29Ah> you get higher rates of production with macroscale techniques 15:28 < fenn> false 15:28 < L29Ah> as you have mechanics and thermodynamics at your side 15:28 < fenn> go read the books, i'm not going to argue 15:28 < docl> yeah that's something you can get with spiroligomers, as they can synthesize each other (being catalysts) 15:28 < L29Ah> "the" books? 15:30 < docl> if you have a chain of catalysts making each other, that's a class of self replicating tech 15:33 < fenn> http://fennetic.net/irc/nanosystems.tar http://fennetic.net/irc/EnginesofCreation2_8803267.pdf http://molecularassembler.com 15:33 < fenn> where'd the zyvex thing go? 15:33 < fenn> also islandone and institute of molecular manufacturing 15:33 < fenn> the stupid internet broke again 15:35 < fenn> http://www.islandone.org/MMSG/ 15:35 -!- spaceangel [~spaceange@ip-94-112-205-34.net.upcbroadband.cz] has quit [Remote host closed the connection] 15:38 < fenn> http://www.zyvex.com/nano/ 15:38 < L29Ah> docl: generally with the current tech if you can make one molecule, you can make a shitload of them (in fact you make one molecule by making a shitload of them), so i don't really see the use cases, except probably for some really complex nanomachine that is hard to make but otherwise capable of self-assebling through catalysis, but that feature would probably constrain the machine a LOT, as you need 15:38 < L29Ah> to make really complex catalysts for reactions to be specific to your bigger intermediate chunks, not the source molecules 15:39 * L29Ah stares at ribosome.gif 15:40 < fenn> little known fact: ribosomes are primarily RNA and the active site is RNA, not protein 15:44 < docl> more catalysts make it possible to do more on a tabletop setup, so macro scale machines/factories that self replicate without hard to manage features like pressure tanks and furnaces are more likely to emerge. think 3d printers but they take rocks or natural gas or something as input 15:45 < docl> like, if you take a ton of dirt from your back yard there's a ton of assorted metals and oxygen right there. not much more energy binding them than a ton of CO2 from a third of a ton of coal. 15:45 < docl> what's missing? either processes -- furnaces, etc. -- or catalysts. 15:45 < L29Ah> more like a slurry of chemical feedstock: thermodynamics is not at your favor in case of rocks 15:46 < docl> it is if you have say, sunlight 15:46 < L29Ah> though there are photocatalyzers 15:46 < docl> exactly 15:47 < docl> and thermal processing is very unfriendly to small scale because of surface area to volume ratio 15:48 < fenn> nanosystems have the same problem with heat rejection, but you can build coolant distribution into it 15:48 < docl> but then you are still spending the energy 15:48 < fenn> you have to spend some energy no matter what 15:49 < fenn> at high production rates there will be a lot of energy dissipated in a small volume 15:49 < docl> sure, but tends to be a lot less if you operate at a lower temperature 15:49 < fenn> no, operating at a lower temperature is a requirement because atoms will jump around on their own and make a mess of things at higher temperatures 15:50 < fenn> the minimum energy dissipated is the same 15:50 < docl> that too. you likely can't run a nanosystem at high temperature. 15:51 < fenn> maybe you can build slightly more efficient tools because they're less massive and it takes less energy to accelerate the arm parts if you don't have to build them big and beefy to withstand thermal noise 15:51 < docl> whereas solution phase chemistry can handle room temperature 15:52 < fenn> you simply can't make the same structures with solution phase chemistry 15:52 < fenn> instead you have to constrain everything with patterns of covalent bonds 15:53 < fenn> no xenon atoms sitting on a surface spelling out "IBM" 15:53 < fenn> the xenon would just fly everywhere instantly 15:54 < docl> any room temperature system shares this property? 15:57 < fenn> i don't know, maybe the solution makes it worse somehow 15:57 < fenn> in addition to thermal noise there's randomness in what the workpiece is exposed to 15:58 < fenn> you could have a slightly more robust workpiece than some xenon atoms, that is able to withstand higher temperatures, but not being exposed to solvent 15:58 < fenn> or there's some equilibrium process involved that makes it so you never get to 100% 15:58 < fenn> the workpiece just keeps dissolving and re-depositing 15:59 < docl> you could use vacuum tech in tandem with solution phase nanotech. the structures won't poof if you evacuate and cool them. you might also use them to create diamond structures of arbitrary shapes, then assemble those with a pick and place system. 15:59 < fenn> so you're limited to reactions that are irreversible (which none are, truly 100% irreversible) 15:59 < fenn> yes i'm a fan of lego bricks 16:00 < fenn> assembling atoms one at a time with precise positioners seems like a waste if you can self assemble bricks of thousands of atoms that are just as good 16:01 < docl> yeah 16:01 < fenn> said bricks need not be rectangular paralellepipeds 16:01 < fenn> parallelepipeds* 16:02 < fenn> carbon nanotubes for example seem like a good building block 16:02 < fenn> or proteins, or maybe spiroligomers (though i haven't read very much about them) 16:03 < fenn> metal organic frameworks, nanoclusters, monolayer films 16:05 < fenn> you can weigh and sort solution grown nanocrystals 16:08 < fenn> with epitaxy the crystals will grow in predictable locations on a framework 16:13 -!- ccdle12 [955adef3@149.90.222.243] has quit [Quit: Ping timeout (120 seconds)] 16:13 < fenn> L29Ah: another aspect of atomically precise manufacturing is that "god is in charge of quality control" - e.g. all carbon atoms are identical (nevermind isotopes for now) so the statistical properties of a system built from identical components are fundamentally different from a bulk system with continuously varying properties 16:14 * L29Ah summons his chunk of monocrystallic silicon to send this message to the irc channel 16:15 < L29Ah> also you somehow imply your production processes will be error-free 16:15 < fenn> when you have an error plugging together lego bricks of consistent size it's much more noticeable than if a jumble of vat solidified stuff is slightly the wrong size 16:15 < fenn> they will not be error free, but the statistics of the process is different 16:16 < fenn> it makes it possible to approach something more like digital matter 16:16 < fenn> things in known exact states that can be reasoned about and proven 16:19 < lsneff> Based on the literature, it should be possible to limit error rates to 1e-12 or lower, iirc 16:26 < fenn> now i'm all riled up 16:27 < fenn> i should probably eat something 16:27 < fenn> mineral epitaxy: https://en.wikipedia.org/wiki/File:Rutile-Hematite-171993.jpg 16:27 < lsneff> doesn't look particularly tasty 16:27 < fenn> https://en.wikipedia.org/wiki/File:Pigtail_from_Single_Crystal_Blade_Casting_shown_with_Kennedy_Half_Dollar_for_size_comparison.jpg 16:37 -!- join_cordblood [~join_cord@135-23-248-163.cpe.pppoe.ca] has joined ##hplusroadmap 17:35 < docl> of course, desktop nanosystems could include cryocooling and vacuum pumps. but the bootstrapping process to get there is expensive. with solution phase stuff you could probably have an inkjet printer make a series of catalysts to build the catalysts, if you have the right recipes. the workload for getting there could be distributed across many desktop scale labs without high vacuum / cryocooling capabi 17:35 < docl> lity.. 17:38 < docl> and for the molecular modeling you can use existing high performance computing servers that have economies of scale and the benefits of many iterations of narrow nanotech (chip fabs). just seems more viable. not necessarily better than throwing a few billion in focused research at the zyvex approach, but more realistic with the given momentum. 17:42 < lsneff> That would be a great startup. 17:44 < fenn> honestly i don't understand how it's even supposed to work 17:45 < fenn> you keep calling them "catalysts" but that doesn't explain how it works at all 17:45 < fenn> add reagents ... and then magic happens ... and you get magic catalysts! 17:46 < fenn> did one of these lisp videos explain it? 17:47 < lsneff> I think the idea is to produce spiroligomers that produce other spiroligomers. Correct me if I'm wrong. 17:48 < docl> yes 17:48 < fenn> add reagents and magic catalysts ... and then magic happens ... and you get magic catalysts!* 17:48 < docl> pretty sure it was mentioned in one or both of the lisp videos, but might have been elsewhere. definitely got the idea from schafmeister somewhere 17:48 < docl> of using spiroligomers to make spiroligomers, that is 17:49 < fenn> well of course 17:49 < fenn> otherwise we're back to desktop DNA synthesis 17:49 < docl> yeah he's not talking dna synthesis 17:49 < fenn> desktop spiroligomer synthesis, block by block 17:50 < fenn> the nobili pesavento universal constructor is a huge monstrosity with a long data tape. how does a spiroligomer create more identical spiroligomers? 17:50 < fenn> does it read its own sequence somehow? does it have an amino acid (?) addition head? 17:51 < fenn> bis-amino acid* 17:51 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-vpyjlfpqwjkjebvf] has quit [Quit: Connection closed for inactivity] 17:52 < fenn> do they just line up that way because like follows like? 17:52 < fenn> complementary base pairing style 17:54 < lsneff> It wouldn't be a universal constructor. Something that creates a copy of itself can be far simpler than a universal constructor. 17:57 < docl> basically the building blocks self assemble under certain conditions, but with the right catalysts you can influence the probability of a given reaction occurring and thus cause given spiroligomers to be built quickly/predictably 17:58 < docl> this is the other (older) talk, it goes into more detail: https://www.youtube.com/watch?v=8X69_42Mj-g 18:00 < docl> .title 18:00 < saxo> YouTube 18:01 < docl> at 11:03 he starts talking about catalysts 18:05 < docl> the building blocks are the amino acid based ring shaped molecules, described at 6:16. so the idea he's describing is to have spiroligomers catalyze the production of these from amino acids instead of having to use process chemistry (which does work, but apparently is expensive). 18:17 < fenn> that's how to build the building blocks, but doesn't explain how to assemble the exact correct sequence of building blocks into the machine that does the catalysis 18:19 < docl> actually I think that part is a stepwise process, not depending on the catalyst. so I described it wrong. once you have the building blocks it's basically following a program/recipe to get the given spiroligomer molecule. 18:19 -!- yashgaroth [~ffffffff@2601:5c4:c780:6aa0:e8fa:1666:b10:730c] has quit [Quit: Leaving] 18:19 < fenn> ok so it's like desktop DNA synthesis 18:20 < fenn> you add drops of liquids in a particular sequence and let the reaction run to completion between each drop, and hopefully you don't get too many errors 18:21 < fenn> longer sequences are exponentially more likely to have bis-amino acid incorporation errors 18:21 < fenn> maybe a few errors doesn't matter though 18:22 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-mrbuudjvdqqhqimy] has joined ##hplusroadmap 18:22 < thahxa> might be less important for peptides and these ring-peptide-like-things than with dna 18:22 < thahxa> b/c extra base or one removed in dna means frameshift 18:22 < fenn> off by one errors are much less of a problem 18:23 < fenn> right 18:23 < thahxa> yea more or less 18:23 < thahxa> at the same time though 18:23 < thahxa> dna synthesis uses the ac2o capping step 18:23 < thahxa> so maybe theres something similar here? 18:24 < thahxa> (random thought in the same direction: i wonder how much better/worse acetyl chloride would be than ac2o) 18:25 < fenn> since there's no way to detect and eliminate errors, even with a very low probability of error you end up with most long chains having an error 18:25 < thahxa> yeah 18:25 < thahxa> with no error correction anyways 18:25 < fenn> er, reactions driven very far to completion* 18:26 < fenn> not low probability of error, as that's basically a tautology 18:26 < fenn> most synthesis errors are deletions 18:27 < thahxa> either deletion or double insertion yep 18:27 < L29Ah> preparative mass-spectrometry plzkthx 18:28 < thahxa> isnt that what a calutron basically was? 18:29 < L29Ah> kinda; i guess peptides need softer handling than uranium though 18:29 < thahxa> yeah 18:29 < thahxa> my thought would be that it'd just be hplc 18:30 < L29Ah> afaik hplc can't separate such peptides well 18:30 < thahxa> then youre kinda outta luck then arent you? 18:30 < thahxa> cuz hplc is used for dna 18:31 < L29Ah> is it used to separate dna from dna-1? 18:31 < fenn> it's like running an agarose gel to determine the length, then cutting out the bands 18:31 < L29Ah> or just some different chunks from other completely different chunks out of your soup? 18:32 < fenn> but with less squishy stuff 18:32 < thahxa> iirc it is used for separating dna from dna-1 18:32 < thahxa> tho theres also dmto adhering whatever stuff 18:33 < fenn> what's dmto? 18:33 < thahxa> dimethoxytrityl 18:33 < thahxa> dna synthesis protecting group 18:36 < lsneff> .t https://news.ycombinator.com/item?id=26063523 18:36 < saxo> The computers rejecting job applications | Hacker News 18:36 < fenn> "The next logical step would be to train an adversarial AI against the hiring AI. You'd have the system generate your resume and application to maximize your chances. Then the hiring AI would need to be re-trained to account for this. And so on. 18:37 < fenn> Anybody who still writes out their resume by hand is considered a luddite weirdo, and definitely not someone you'd want to have join your company." 18:38 < thahxa> my next resume is gonna just be 3000 resumes put into gpt-neo and the first 300 words that comes out of that 18:39 < lsneff> "I kind of rambled on about this in another comment on this thread, but I paid someone $250 to optimize my resume with key words to appease AI. It worked. I got automated replies to schedule phone screenings from jobs that had rejected my old resume. It's already happening." 18:39 < L29Ah> plot twist: the industry switches to tiktok resumes 18:39 < fenn> "Growth opportunities I look forward to exploring" and then a long list of buzzwords and fad technologies in white text on a white background 18:39 < fenn> awesome suggestion 18:39 < lsneff> Yeah, I thought that was funny 18:40 < thahxa> the next thing that happens is that people start giving the tiktok resume both adversial static 18:40 < lsneff> I wish it was clearer how to make resume parsable by companies 18:44 < lsneff> honestly, pdfs are just such a shitty format for this 18:46 < L29Ah> 05:39:29] plot twist: the industry switches to tiktok resumes 18:46 < L29Ah> it was supposed to be a joke, but quick googling suggests it is a thing already 18:46 < lsneff> wait what 18:46 < lsneff> seriously? 18:49 < fenn> this sounds ripe for trolling 18:50 < lsneff> https://www.vice.com/en/article/889ymz/as-the-job-market-collapses-gen-z-is-making-resumes-on-tiktok 18:53 < fenn> "I've made a TikTok about why you should hire me! (Hint: it's for my dog 🙃) 18:53 < fenn> will someone please think of the dog-children 18:57 < fenn> that chonker needs more snausages! 19:05 < fenn> "made me play a number of simple online games from the comfort of my own home. 19:05 < fenn> These included having to quickly count the number of dots in two boxes, inflating a balloon before it burst to win money, and matching emotions to facial expressions. Then an artificial intelligence (AI) software system assessed my personality, and either passed or failed me." 19:05 < fenn> totally not an IQ test, because that would be illegal crimethinc(tm) 19:07 < thahxa> are iq tests actually illegal? i thought they were fine for employment 19:07 < lsneff> if an application asked me to do a personality test, I'd probably just not submit it 19:08 < L29Ah> lsneff: why? 19:08 < fenn> http://en.wikipedia.org/wiki/Griggs_v._Duke_Power_Co. 19:11 < lsneff> L29Ah: a company that is so large as to require that much filtering is probably not doing something very interesting 19:11 < lsneff> then again, I might do it because I just need a job 19:13 < L29Ah> ah, yeah, huge corporations aren't fun 19:14 < lsneff> even msft isn't doing that kind of filtering 19:14 < fenn> how do you know? 19:14 < lsneff> I interned there twice 19:14 < fenn> did you walk in the front door or were you referred? 19:15 < fenn> (implicitly vouched-for) 19:15 < lsneff> Not referred. Talked to recruiters who came to my university. Hmm, I guess that could've pushed through any filtering. 19:16 < lsneff> My friends haven't said anything about it though, so I don't think they are 19:21 < L29Ah> 06:08:30] http://en.wikipedia.org/wiki/Griggs_v._Duke_Power_Co. 19:21 < L29Ah> ohh that's why goog floods you with programming/compsci tasks instead 19:21 < fenn> eh? 19:22 < fenn> programming/CS is highly relevant to most jobs at google 19:23 < fenn> it's probably an even better predictor of job performance than IQ 19:23 < lsneff> They're probably directly correlated anyhow 19:23 < L29Ah> CS is mostly irrelevant to web and systems programming 19:24 < fenn> google does a lot of stuff at large scale, where knowledge of algorithms is important for even seemingly mundane problems 19:24 < L29Ah> aptitude at the technologies involved is more important 19:25 < fenn> a single programmer can accidentally tie up hundreds of millions of computers, wasting large amounts of electricity and machine time 19:25 < L29Ah> fenn: what algorithms do you need to know (more than their purpose and performance criteria alone) for (even not so) mundane problems? 19:26 < fenn> i don't work at google 19:26 -!- jcorgan [~jcorgan@unaffiliated/jcorgan] has quit [Quit: leaving] 19:27 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-feigsoxbyvjberaf] has quit [Ping timeout: 264 seconds] 19:27 < fenn> big-O notation IS performance criteria 19:27 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-vrfvyczcignesbni] has quit [Ping timeout: 260 seconds] 19:27 -!- wallet42____ [sid154231@gateway/web/irccloud.com/x-jujxerrvfrbgtepo] has quit [Read error: Connection reset by peer] 19:27 -!- acertain [sid470584@gateway/web/irccloud.com/x-qcnlnbxhzvnipgcz] has quit [Read error: Connection reset by peer] 19:27 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-vacykevlcltjliir] has quit [Read error: Connection reset by peer] 19:27 < L29Ah> yes, and you don't need to know the implementation details or be able to implement the algorithm to know its big-O 19:27 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-mrbuudjvdqqhqimy] has quit [Ping timeout: 258 seconds] 19:28 < fenn> sometimes you need to implement an algorithm even if it is commonly used 19:28 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-pirbjhmuppbmnvuo] has joined ##hplusroadmap 19:28 -!- wallet42____ [sid154231@gateway/web/irccloud.com/x-ihozpqrvbxpcilcr] has joined ##hplusroadmap 19:28 < L29Ah> today almost no one needs to think out or implement an algorithm that is not just a few common ones clumped together using their interfaces, if we aren't talking research positions in the first place (that should have a separate hiring process as it's much different from sweng in the required skills and attitudes) 19:28 < fenn> this is like complaining about having to know spelling because there exist spell-checkers 19:28 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-iohsmtwfjecwgeft] has quit [Ping timeout: 258 seconds] 19:29 -!- EnabrinTain [sid11525@gateway/web/irccloud.com/x-kgkfknwwbiwecjzh] has joined ##hplusroadmap 19:29 < lsneff> why are you guys arguing about this again? 19:29 < L29Ah> and i can read the ideas for the implementation in the thick book of algorithms of the decade 19:29 < fenn> people just like to argue apparently 19:29 < L29Ah> huh, have i argued about this already? 19:30 < fenn> again = idiom "please explain why" 19:30 < fenn> something like that anyway 19:31 < L29Ah> yeah, pretty much; arguing is good for you! 19:31 < fenn> too much argument makes jack a sour boy 19:31 -!- s0ph1a [sid246387@gateway/web/irccloud.com/x-avgfjervieragkwx] has joined ##hplusroadmap 19:32 * L29Ah goes back to implementing a FTP client for a RTOS-less MCU bootloader 19:33 -!- acertain [sid470584@gateway/web/irccloud.com/x-pfvaigabdrzptrjm] has joined ##hplusroadmap 19:33 -!- rodarmor [sid210835@gateway/web/irccloud.com/x-fivmykcoehvwjrdb] has joined ##hplusroadmap 19:35 -!- Solgriffin [sid282649@gateway/web/irccloud.com/x-ggrchdsqaxuvlwhj] has joined ##hplusroadmap 19:43 * lsneff is implementing a replacement for gtkwave 20:02 -!- justanotheruser [~justanoth@unaffiliated/justanotheruser] has joined ##hplusroadmap 20:04 -!- justan0theruser [~justanoth@unaffiliated/justanotheruser] has quit [Ping timeout: 265 seconds] 20:28 -!- darsie [~kvirc@84-113-55-200.cable.dynamic.surfer.at] has quit [Ping timeout: 272 seconds] 20:36 < lsneff> hmm, maybe I should look into kernelco 20:41 -!- filipepe_ [uid362247@gateway/web/irccloud.com/x-pirbjhmuppbmnvuo] has quit [Quit: Connection closed for inactivity] 21:56 -!- Codaraxis__ [Codaraxis@gateway/vpn/mullvad/codaraxis] has joined ##hplusroadmap 21:59 -!- Codaraxis_ [~Codaraxis@ip68-5-90-227.oc.oc.cox.net] has quit [Ping timeout: 265 seconds] 22:27 < fenn> ...We shall win new feelings, superior to love and loyalty, from the field of the human heart. https://assets.gocomics.com/uploads/blogs/blog_image_large_4086_7578_Emoji_Day_Comics_201707061109.jpg 22:47 < fenn> "Each civilization has its royal affect, and its ignored or forgotten feelings. You have learned that in the human heart, love resides within such and such a circle, hate there in another, and between are pride, jealousy, all the royal and plebeian emotions. We say instead emotion is one unbounded field. Our way of life causes us to cross this field, now in one direction, now another, again and 22:47 < fenn> again on our way to the goals to which our world has constrained us. The paths crisscross, and eventually the field has well-travelled intersections, and blank areas where we 22:47 < fenn> have never walked. We name the intersections just as we do towns but not 22:47 < fenn> the empty fields between them. We name these oft-crossed places love, hate, jealousy, pride. But our destinations were made by the conditions of our lives, they are not eternal or inevitable. 23:04 -!- thahxa [~thahxa@vlnsm4-toronto63-142-122-136-238.internet.virginmobile.ca] has quit [Ping timeout: 240 seconds] 23:08 < nmz787_> L29Ah: electron beam lithography is a LOT higher resolution and cheaper than x-ray litho --- Log closed Tue Feb 09 00:00:24 2021