--- Log opened Sat Apr 10 00:00:21 2021
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06:32 < kanzure> CRISPRoff for methylation reprogramming https://doi.org/10.1016/j.cell.2021.03.025
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09:27 < jrayhawk> wow
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17:01 < kanzure> yeah
17:03 < L29Ah> can it demethylate?
17:06 < L29Ah> the fourth day into GHRP-6 injection schedule have passed, and i'm already annoyed and anxious about the risk of getting scarring from all the injections
17:06 < L29Ah> peptides sux
17:07 < kanzure> well, is there a demethyltransferase?
17:08 < kanzure> TET1
17:09 < kanzure> (demethylase)
17:10 < kanzure> looks like people have made cas9 fusion proteins with TET1/demethylase so there's your answer
17:31 < kanzure> anyone have a copy of the CRISPRoff  manuscript?
17:37 < kanzure> huh, the articles don't say what methyltranferase they are using
17:39 < gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=cb6708a5 Bryan Bishop: the other CRISPRoff (not the light activation one) >> http://diyhpl.us/diyhpluswiki/gene-editing/
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--- Log closed Sun Apr 11 00:00:22 2021