--- Log opened Thu Jul 29 00:00:22 2021 00:31 -!- johest [~johest@user/johest] has quit [Ping timeout: 265 seconds] 00:33 -!- johest [~johest@user/johest] has joined #hplusroadmap 01:25 < fenn> .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020930/ 01:25 < saxo> Aerosols Transmit Prions to Immunocompetent and Immunodeficient Mice 01:25 < fenn> for very slow biowarfare 01:27 < fenn> can one make an antibody serum antidote to a specific prion? 01:33 < L29Ah> sure 01:33 < fenn> and would it do any good 01:38 < L29Ah> perhaps 01:38 < L29Ah> artificial anti-cancer antibodies kinda work 01:38 < fenn> cancer is a lot more slippery 01:38 < L29Ah> with gruesome side effects tho, but that is likely because killing a cell is much harder than conjugating a protein 01:39 < L29Ah> .t https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157205/ 01:39 < saxo> Immunotherapy against Prion Disease 01:39 < fenn> i wonder if the antibody might not just cause the protein to misfold 01:47 < fenn> "antibodies induced by vaccination will at least reduce PrPSc in the peripheral tissues and prevent the shedding of CWD prions, which is believed to be a main reason for the efficient lateral transmission of CWD" (chronic wasting disease) 01:48 < fenn> alright boys, time to load up yer dart guns with vaccines, we got some wobbly deer to shoot 01:49 < L29Ah> well it may mark it for clearance by leukocytes in proper tissues, but in the brain you're probably screwed^W^W^Widk how to ask astrocytes to harvest garbage 01:49 < fenn> antibodies don't cross blood-brain barrier 01:49 < fenn> not enough of them anyway 01:50 < L29Ah> yup, but they're talking about small molecules also 01:51 < L29Ah> in the worst case you can just disable the autocatalyticity of the protein and let it be tho 01:52 < fenn> you'd have to take that drug for life 01:52 < fenn> and your friends and family would be unable to eat you 02:13 < L29Ah> why not? just add some pepsins 02:13 < fenn> you think it would all "wash out" over time? 02:13 < fenn> through sheer churn 02:13 < L29Ah> i think that chunks of prions are as safe as other peptides 02:14 < L29Ah> tfw bought pineapple 02:14 < fenn> i don't know what happens to a human with active pepsins chewing on everything 02:14 < L29Ah> at first i was like "i eat pineapple" 02:14 < L29Ah> but then the pineapple ate me 02:14 < fenn> in soviet L29Ah-istan 02:15 < L29Ah> 12:14:13] i don't know what happens to a human with active pepsins chewing on everything 02:15 < L29Ah> well i'd start with boiling the human meat thoroughly first 02:15 < L29Ah> and tossing pepsins after 6-12h of such cooking 02:15 < fenn> oh.. i thought you meant injecting pepsins or some kind of gene therapy 02:16 < fenn> yeah i sure as hell wouldn't touch that with a biohazard suit and a remote manipulator cell 02:16 < L29Ah> but boiling itself might be enough if the prions are denatured and won't misfold on their own 02:16 < fenn> cooking doesn't prevent transmission 02:16 < L29Ah> maybe because people love undercooking meat? 02:17 < fenn> maybe. i think there just isn't a level of cooking that results in "meat" which doesn't also have enough prions in it to cause disease 02:17 < L29Ah> when i tell people that i boil meat, they tell me i'm doing it wrong 02:17 < fenn> meh 02:18 < fenn> something something sous vide protocol 02:18 < L29Ah> at least here meat is roasted or grilled 02:18 < L29Ah> sous vide sounds low temp 02:18 < L29Ah> *usually 02:19 < fenn> it's just a more controlled and predictable application of heat via hot water, with plastic to seal the meat juice in 02:19 < L29Ah> if we're speaking tribes dying of familial prion disease, i doubt they boil it 03:36 -!- lsneff [~lsneff@2001:470:69fc:105::1eaf] has quit [Quit: Bridge terminating on SIGTERM] 03:36 -!- lsneff_ is now known as lsneff 03:40 -!- lsneff1 [~lsneff@2001:470:69fc:105::1eaf] has joined #hplusroadmap 07:01 < lsneff1> "Lachlan Sneff: let them live out..." <- There's plenty of space down here to go homesteading if they really want 07:02 -!- lsneff is now known as lsneff_ 07:03 -!- lsneff1 is now known as lsneff 11:40 -!- juri_ [~juri@178.63.35.222] has joined #hplusroadmap 11:42 < juri_> anyone here know anything about cellbricks.com? halfway considering dropping them a resume. 12:42 < maaku> lsneff: not free and ungoverned space, no there isn't 12:45 < maaku> I mean I would have gone to mars 20 years ago if the opportunity was available 12:45 < maaku> Back when I was young and stupid. 12:49 < lsneff> "anyone here know anything..." <- No, but looks neat. 12:50 < lsneff> "Lachlan Sneff: not free and..." <- That's true. Mars won't be ungoverned either though once it's established in any way. 12:59 < nmz787> 18:57 < lsneff> It basically covers anything that uses electrochemical processes on a grid to make a 3d object 12:59 < nmz787> oops 12:59 < nmz787> .title https://www.youtube.com/watch?v=bQy1PUSw77M 12:59 < saxo> The Drones of the Olympic Games #Tokyo2020 - YouTube 12:59 < nmz787> interesting that these are pretty much true volumetric displays 13:01 < lsneff> There's some research being done on using sonic traps to move around particles illuminated by lasers. 13:01 < lsneff> Looks similar, but on a much smaller scale 13:42 < nmz787> ah that's cool 14:03 < maaku> nmz787: see also the korean olympics opening 16:10 < fenn> an intimidating show of strength by the secret robot military 16:11 < fenn> this "olympics" is merely a test of their humanoid infiltration units' performance 16:31 < lsneff> you should write fiction 20:59 < L29Ah> certainly not miltary 21:00 < L29Ah> military would use anabolics at the very least! 22:39 < maaku> lsneff: I shouldn't have been so snappy earlier. Going to Mars would be a very worthwhile endeavour. 22:39 < maaku> For society at least. I've grown roots where I am. 23:46 -!- CryptoDavid [uid14990@id-14990.highgate.irccloud.com] has joined #hplusroadmap --- Log closed Fri Jul 30 00:00:23 2021