--- Log opened Sun Oct 24 00:00:12 2021
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07:13 < kanzure> "Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging" https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13492
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08:57 < Thane> Hi there
09:14 < fenn> .title https://www.telegraph.co.uk/global-health/climate-and-people/mozambique-elephants-born-without-tusks-evolutionary-response/
09:14 < saxo> Elephants born without tusks in ‘evolutionary response’ to violent poachers
09:14 < fenn> couldnt we genetically engineer elephants without tusks, but without the mutation that affects males
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10:14 < kanzure> make them poisonous
10:30 < fenn> they turn the tusks into decorative carving, they don't eat it
10:30 < fenn> or i guess you could have like a giant hedgehog elephant hybrid
10:31 < fenn> anyway it says the harmful mutation is "linked" which means that it's not the same mutation
10:31 < fenn> probably just close by on the chromosome
10:51 < Thane> Better to "genetically engineer" the poacher-types out of the planet
10:51 < Thane> Anyways
10:52 < Thane> Do you guys have any suggestions on replacements for caffeine?
10:52 < Thane> I hear ginseng, gingko, rosewood extract etc are good, but I've no idea if they're potent
10:53 < fenn> modafinil
10:53 < Thane> what's that?
10:53 < fenn> a drug with caffeine-like effects, used to stay awake
10:54 < fenn> methylphenidate is another drug that's commonly used for studying and doing repetitive tasks
10:56 < Thane> Is modafinil easily accessible?
10:56 < Thane> or would getting a prescription be as simple as asking a doctor, do you think?
10:57 < fenn> yes, and there is a non-prescription prodrug called adrafinil which is slightly less safe when used long-term
10:57 < fenn> in general people take doses of drugs that are far too high, and this applies to modafinil and methylphenidate too
10:58 < fenn> a quarter tablet of modafinil (50mg) is more than enough
10:58 < Thane> I am on methylphenidate atm
10:59 < fenn> it's probably not a good idea to mix MAOIs (ginkgo) with dopaminergics (methylphenidate)
10:59 < Thane> Tbh after having read an article on cerebral allergies, I suspect that the adhd they discovered might in part be that. Thus I want to minimise caffeine-use, because I hear you get used to methylphenidate very fast, and that it can exacerbate caffeine-induced cerebral allergy
11:00 < Thane> Why not?
11:00 < fenn> the effects multiply together
11:00 < fenn> it's hard to dose correctly, and there could be circulatory side effects (?)
11:00 < Thane> Ah ok
11:01 < Thane> I mean I only buy the stuff from the biopharmacies, i.e. glorified nutrition supplement-shops
11:01 < Thane> Idk if it would be potent enough
11:01 < Thane> I guess I mainly use the gingko because of the countering effect on bloodvessel-shrinkage in the brain
11:01 < fenn> most drugs are derived from purified plant extracts
11:01 < Thane> (also brought about by caffeine)
11:02 < Thane> Fair enough
11:02 < Thane> Have you heard about cerebral allergies before?
11:02 < fenn> sounds like BS but i'm not interested in arguing at the moment
11:02 < Thane> Nah I wouldn't argue, only curious
11:02 < Thane> The concept is disputed, but gaining attention
11:03 < Thane> I can post the link to where I heard about it if you want
11:04 < Thane> http://www.doctoryourself.com/caffeine2.html
11:16 < Thane> Anyways, thanks for the advice!
11:17  * fenn tips hat
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17:14 < lsneff> How does whole-brain emulation become a mainstream view for the average person?
17:19 < superkuh> Use in a popular sitcom as a plot.
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22:21 < jrayhawk> oh, the myocarditis looks to be caused by a procedural injection error, and children just have denser vascularization https://pubmed.ncbi.nlm.nih.gov/34406358/
--- Log closed Mon Oct 25 00:00:13 2021