--- Log opened Wed Nov 03 00:00:22 2021
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02:35 < nsh> Malvolio, what do you imagine the benefit to humans might be of having vitrified cells?
02:38 < nsh> the fremen have stillsuits which drastically reduce the degree of water pervasion from the human dermis. they don't live forever. if you reduced it to zero it would be somewhat difficult to maintain homeostasis i would imagine
03:07 < nsh> or for some kind of (non-cryo)stasis maybe...
03:09 < nsh> <nsh> the tardigrades also use amorphous "intrinsically disoredered proteins" which to some extent replace the water in their cells
03:09 < nsh> <nsh> *disordered
03:09 < nsh> <nsh> this may only be effective up to a certain complexity of the proteins interacting within them as a substitute medium
03:09 < nsh> <nsh> who knows
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04:40 < kanzure> "Non-magnetic objects induced to move by electromagnets" https://www.nature.com/articles/d41586-021-02771-5 https://arc.aiaa.org/doi/abs/10.2514/1.A33320
04:42 < kanzure> ugh https://twitter.com/stricklebee/status/1455827815098511367
04:46 < kanzure> "Modularity and neural coding from a brainstem synaptic wiring diagram" https://www.biorxiv.org/content/10.1101/2020.10.28.359620v1.full
04:46 < kanzure> see figure 1a in particular
04:52 < kanzure> "Accurate prediction of protein structures and interactions using a 3-track network" https://www.biorxiv.org/content/10.1101/2021.06.14.448402v1
04:53 < kanzure> https://robetta.bakerlab.org/
05:06 < kanzure> https://future.a16z.com/what-we-learned-doing-fast-grants/
05:10 < kanzure> https://patrickcollison.com/fast
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10:28 < docl> hmm. would that be the protein that synthesizes a bunch of trehalose? that's on my short list of plausible approaches to bioreversible cryonics
10:30 < docl> synthesis or uptake... it's a sugar mammals don't really use, so we lack the proteins for facilitated diffusion or synthesis
10:30 < docl> we do have an enzyme to break it down into glucose, but that's counterproductive
10:33 < docl> it has some neuroprotective effects, so there's a bit of research on it
10:33 < docl> https://www.nature.com/articles/s41419-018-0749-9
10:33 < docl> .title
10:33 < saxo> Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction | Cell Death & Disease
10:34 < docl> lol "Deuterium-derived primitive organisms also do not own trehalose-synthesizing genes"
11:08 < docl> Oh I see, that's nothing to do with heavy hydrogen but evolutionary ancestry
11:08 < docl> .title https://en.wikipedia.org/wiki/Deuterostome
11:08 < saxo> "Deuterostomia /ˈdjuːtəroʊstoʊmiə/ (lit. 'second mouth' in Greek) are animals typically characterized by their anus forming before their mouth during embryonic development." - https://en.wikipedia.org/wiki/Deuterostome
11:09 < nmz787> lifelong lesson takeaway from highschool biology class, when another kid blurted out "I'm a deuterostome, my ass came first!"
11:09 < docl> Was wondering how they manage to derive life forms from heavy hydrogen
11:11 < docl> I wonder if the article has a typo or deuterium is considered correct usage... Wikipedia does not have a see also for deuterium so probably a typo
11:13 < Malvolio> (well like without the whole liquid nitrogen thing. or in addition to)
11:15 < Malvolio> (if tardigrades can come back to normal they maybe we can too)
11:16 < Malvolio> :x bbl
11:17 < docl> Yeah helps with higher temp vitrification, depending how much water replacement you can manage. even a small amount can mitigate the issues of other solutes
11:18 < docl> even just dry ice cryonics would be a lot cheaper
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--- Log closed Thu Nov 04 00:00:22 2021