--- Log opened Wed Nov 10 00:00:28 2021
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01:23 < fenn> doudna is at it again http://www.science.org/content/article/why-delta-so-infectious-new-lab-tool-spotlights-little-noticed-mutation-speeds-viral-spread
01:24 < fenn> .title https://www.science.org/doi/10.1126/science.abl6184
01:24 < saxo> Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles
01:25 < fenn> "We found a possible reason the Delta variant is spreading so quickly! 10X higher RNA packaging in our model system."
01:27 < fenn> higher payload delivery efficiency would help with gene therapy
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07:39 < kanzure> https://blog.robertelder.org/how-to-make-a-cpu/
07:40 < Malvolio> https://www.nbcnews.com/news/us-news/ability-force-recalls-fda-can-only-warn-consumers-benzene-hand-sanitiz-rcna4585
08:19 < lsneff> > how to make a cpu except I don’t actually know how to make a cpu, just the general process 
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09:26 < fltrz_> new IRC client test
09:26 < fltrz_> check :)
09:27 < fltrz_> so I have recently had an idea to replace focus stacking with realtime all optical setup using multiple "ideal lenses" to have a whole volume "in focus"
09:28 < fltrz_> from preliminary analytical analysis (using ideal lenses) this seems entirely possible. Not sure why humanity has stuck to using planar focusing throughout history.
09:29 < fltrz_> also the whole "focus stacking" community highlights demand for such a thing, but is an inelegant solution
09:31 < fltrz_> the problem with single lens (or essentially single lens) microscopes is that the magnification is dependent on depth, and the volume of interest (even if care was taken to design the optical setup for constant magnification as a function of depth) that this image isn't placed beyond the hyperfocal distance
09:33 < fltrz_> assuming ideal lenses its essentially an exercise of inserting in computer algebra system the  1/x_1 + 1/x_2 = 1/f map
09:34 < fltrz_> and then trying one by one a single lens magnification system, a dual lense system, a triple lens system etc, to find the lowest number of lenses that allow the final map to be a 3D scaling as opposed to a 2d scaling
09:35 < fltrz_> a 3D scaling is just a map such that the magnification is constant as a function of depth of an object
09:38 < fltrz_> in SageMath CAS, you essentially use the N times iterated (for N lens system) lens map, where each lens has a focal length and a position, and then you get a rational polynomial, and you set the required coefficients that prevent a linear scaling to 0, which gives the equations that determine the needed positions and focal lengths
09:38 < fltrz_> I'm astounded this wasn't done before?
09:46 < fltrz_> perhaps it was presumed impossible? perhaps each next generation overestimated the skills of the previous generations of designers of magnification systems?
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09:48 < fltrz_> its was tacitlyt assumed impossible? generating an impossibility theorem for such a thing is straightforward: objects and image planes are conjugate, so whatever optical system, the sensor plane will correspond to a specific input plane at the object
09:48 < fltrz_> but this ignores the finite resolution of any imaging sensor, which is what results (together with aperture) in a hyperfocal distance
09:50 < fltrz_> for example in a microscope even a fraction of a milimeter defocus will result in blurring, but take a picture of mountains in the distance and they seem in focus even if one mountain is a kilometer further away than the other
09:51 < fltrz_> technically when taking a picture of such mountains at distinct distances, the image sensor plane will map to a specific distance and those mountains are not at that distance and technically "out of focus", the limited resultion means they are still in focus with respect to the pragmatic finite resultion of the image sensor
09:52 < fltrz_> so really to have the same phenomenon in microscopy, all we need to do is insist the compound system of lenses should have constant magnification, both laterally and in depth, and that this magnification should be independent of depth of the object
09:53 < fltrz_> aka solving a system of equations
09:54 < fltrz_> since the niche is proven (people go out of their way to have non-realtime focus stacking setups), this should be a viable product, and since it doesn't rely on digital processing, it would be realtime, so it would increase the size of the niche market
09:56 < fltrz_> I suspect I am too lazy to actually build the setup, let alone start a small home factory for such setups, so perhaps I should just crunch the equations and publish the theoretical proof of concept?
11:31 < muurkha> yes
11:32 < muurkha> for sure
11:42 < fenn> well that's a wall of text. have you heard of plenoptic imaging?
11:45 < redlegion> my company makes a CNC measurement machine with three axis of movement that uses a plenoptic camera for its detection sensor
11:45 < redlegion> sad to say our product is just the "least shitty option in the field"
11:47 < lsneff> .wik Interference_lithography
11:47 < saxo> "Interference lithography (or holographic lithography) is a technique for patterning regular arrays of fine features, without the use of complex optical systems or photomasks. /  The basic principle is the same as in interferometry or holography." - https://en.wikipedia.org/wiki/Interference_lithography
11:47 < lsneff> .wik Electron-beam_lithography
11:47 < saxo> "Electron-beam lithography (often abbreviated as e-beam lithography, EBL) is the practice of scanning a focused beam of electrons to draw custom shapes on a surface covered with an electron-sensitive film called a resist (exposing).  The electron beam changes the solubility [...]" - https://en.wikipedia.org/wiki/Electron-beam_lithography
12:02 < docl> "Electron-beam lithography systems used in commercial applications are dedicated e-beam writing systems that are very expensive (> US$1M). For research applications, it is very common to convert an electron microscope into an electron beam lithography system using relatively low cost accessories (< US$100K)."
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13:45 < muurkha> lsneff: so how do you build your SNN circuits?  what inputs have you been able to differentiate with them?
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--- Log closed Thu Nov 11 00:00:29 2021