--- Log opened Tue Nov 16 00:00:34 2021
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07:17 < fenn> "Systematic napping"
07:17 < fenn> how to rapidly eliminate caffeine from the body? say you have suddenly a need to be asleep, for example you learn you will need to wake up early, but you have just drank coffee or whatever
07:18 < fenn> (have drunk?)
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07:19 < fenn> (Drank is the past tense of to drink. Drunk is the version used after had, has, or have i.e., the past participle)
07:27 < fenn> .title http://carcin.oxfordjournals.org/content/21/6/1157.long
07:27 < saxo> Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets | Carcinogenesis | Oxford Academic
07:27 < fenn> "a diet rich in cruciferous vegetables (broccoli, cauliflower, brussel sprouts, etc.) increased production of CYP1A2. Conversely, a diet heavy in apiaceous vegetables (carrots, celery, dill, etc.) reduced CYP1A2."
07:28 < fenn> i wonder if this is related to sulforaphane
07:51 < L29Ah> fenn: i doubt there's a way to speedup caffeine elimination radically w/o seriously messing up metabolism
07:51 < L29Ah> but you can try counteracting it with sedatives
07:52  * L29Ah easily feels pumped up from caffeine and sleepy at the same time; sleep is certainly possible and much easier than with phenylethylamines
08:00 < fenn> i was wondering if there was something simple and straightforward like exercise
08:14 < fenn> "Cigarette smoking induces (increases activity of) the CYP1A2 enzyme which in turn makes the enzyme work faster and harder. Thus, anything metabolized by 1A2 will have a shorter life in the human body and thus have less effect overall. Thus, cigarette smoking decreases the effects of caffeine due to enzyme induction."
08:14 < fenn> well shit
09:04 < docl> cigarettes specifically or nicotine in general?
09:07 < fenn> nicotine
09:07 < fenn> which is still bad for you btw
09:08 < fenn> uh no actually cigarettes
09:08 < fenn> "ts expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke."
09:09 < fenn> its*
09:10 < fenn> "Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme"
09:11 < fenn> PAHs are also in burned foods
09:12 < fenn> theophylline is an inhibitor
09:14 < fenn> melatonin is a substrate (degraded by CYP1A2)
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09:39 < muurkha> your body is a mixture of materials
09:40 < muurkha> in general the answer to the question "I have this mixture of many materials and I want to rapidly eliminate one; how do I do it?" is "you can't, you're sort of fucked", with occasional exceptions
09:53 < fenn> apparently smoking can reduce caffeine's half life by 30-50%
09:54 < fenn> that's not nothin
09:54 < fenn> i'd also accept answers of the form "add adenosine" if that were somehow possible (i haven't looked into it)
09:58 < muurkha> concur!
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14:43 < kanzure> https://astera.org/parpa/
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17:41 < lsneff> Looks similar to the Convergent FROs
17:47 < lsneff> I do like that the astera site mentions molecular assemblers being a goal
17:48 < lsneff> I think convergent FROs is more interested in brain emulation
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--- Log closed Wed Nov 17 00:00:35 2021