--- Log opened Wed Dec 29 00:00:14 2021
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02:32 < fenn> bbrittain: this is the same world where digging a subway tunnel costs a billion dollars a mile
02:32 < fenn> probably related
02:33 < fenn> bbrittain: maybe you could work on first principles cost estimation software
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03:16 < L29Ah> 13:32:30]<fenn> bbrittain: this is the same world where digging a subway tunnel costs a billion dollars a mile
03:16 < L29Ah> moscow subway does it 15-20 times cheaper, including the stations
03:19 < fenn> get moscow on the geoengineering train then
03:19 < fenn> we can have a good old fashioned geoengineering race
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06:30 < kanzure> gametogenesis company https://www.ivynatal.com/
06:41 < kanzure> https://www.ivynatal.com/blog/new-progress-on-direct-reprogramming-for-ivg
06:43 < kanzure> "First, we are leveraging more computational methods to identify transcription factors to drive meiosis and reprogramming. We believe this is important because we are working with human cells, and human egg cell data is scarce relative to mice, and because of the complexity of the process of egg cell development. (If you’re interested in the basics of our approach, we wrote another blog post ...
06:43 < kanzure> ...recently about our earliest, surprising results predicting direct reprogramming targets.)"
06:46 < kanzure> "The model we have built for human transcription factors predicts their DNA binding sites, which is related to which genes the transcription factors may modify the expression of. Individually, these predictions could be used to study the function of each transcription factor, but our goal is to understand the relationship between a cell’s identity, whether it is a skin cell or an egg cell, ...
06:46 < kanzure> ...and the transcription factors active in the cell ... feature extraction to identify the transcription factors that are relatively more active between our cell types, which helps us further narrow the set of potential transcription factors to directly reprogram skin cells into egg cells"
06:47 < kanzure> "Reconstitution of the oocyte transcriptional network with transcription factors" https://www.nature.com/articles/s41586-020-3027-9
07:40 < kanzure> another gametogenesis company https://conception.bio/
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09:55 < kanzure> "Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation" https://www.nature.com/articles/s41557-021-00773-4
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10:42 < kanzure> geneh: welcome back
11:30 < geneh> hey
11:34 < kanzure> https://www.omg.org/spec/SyM/
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12:50 < lsneff> > SysML reuses a subset of UML 2 constructs
12:51 < lsneff> gross
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14:03 < muurkha> not sure if SysML is a useful thing
14:04 < muurkha> my dad is enthusiastic about it
14:18 < L29Ah> is this just a file format for 2d diagrams, like svg but a lil higher-level?
14:19 < L29Ah> all the text around it sounds very, ehm, enterprise-grade
14:34 < lsneff> Except for digital logic design, i can’t see UML diagrams or anything like them being useful
14:38 < muurkha> I think the idea is that when you're designing, say, a helicopter engine, you need some common representation for communication between the ECU team, the hydraulics team, the turbine aerodynamics team, the DFM folks, etc.
14:40 < muurkha> because neither a mechanical view nor a schematic can represent most of the important aspects of the design
14:40 < muurkha> I don't know if this actually works in practice, but that's the idea
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--- Log closed Thu Dec 30 00:00:15 2021