--- Log opened Sun Apr 03 00:00:44 2022
00:00 < muurkha> maaku: yeah, I was thinking that possibly less anxiety would help me focus better, since anxiety is a major factor in procrastination
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05:29 < maaku> nmz787_: lol
05:30 < maaku> muurkha: I see the logic I guess. depends on what your procrastiation blocker is
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06:11 < redlegion> ADHD sucks.
06:12 < redlegion> the meds are great for a while, but eventually you'll end up playing a tolerance game, trying to take occasional breaks to keep the efficiency of the med afloat.
06:13 < redlegion> though I'd be a good deal worse off overall had I not sought my diagnosis.
06:14 < redlegion> well, honestly, it wasn't something I was seeking. it was slapped on me after I described my education history.
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06:57 < lsneff> maaku: I’m starting the process, but I’m leaving this area in 3-4 weeks for the summer, so I’m not sure I’d have time to get through it
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09:40 < muurkha> maaku: didn't work
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10:54 < kanzure> "Viable offspring derived from single unfertilized mammalian oocytes" https://www.pnas.org/doi/10.1073/pnas.2115248119
10:55 < kanzure> cc yashgaroth 
10:57 < kanzure> "We report live mammalian offspring derived from single unfertilized oocytes, which was achieved by targeted DNA methylation rewriting of seven imprinting control regions. Oocyte coinjection of catalytically inactive Cas9 (dCas9)-Dnmt3a or dCpf1-Tet1 messenger RNA (mRNA) with single-guide RNAs (sgRNAs) targeting specific regions induced de novo methylation or demethylation, respectively, of ...
10:57 < kanzure> ...the targeted region. Following parthenogenetic activation, these edited regions showed maintenance of methylation as naturally established regions during early preimplantation development. The transfer of modified parthenogenetic embryos into foster mothers resulted in significantly extended development and finally in the generation of viable full-term offspring. These data demonstrate that ...
10:57 < kanzure> ...parthenogenesis can be achieved by targeted epigenetic rewriting of multiple critical imprinting control regions."
10:58 < muurkha> nice!
11:02 < yashgaroth> yeah the targeted methylation/demethylation is interesting, could be useful for designer babies if there's issues with imprinting regions after extended in vitro culture. Btw this is with pre-meiotic oocytes that have both sets of chromosomes, so...identical genome to the parent but with chromosomal rearrangement between each pair of chromosomes? I forget my devo bio
11:03 < yashgaroth> fulltest http://civica.com.es/wp-content/uploads/2022/03/pnas.2115248119.pdf
11:03 < yashgaroth> text, rather
11:03 < muurkha> what mammal?
11:04 < yashgaroth> extremely inbred lab mice
11:05 < muurkha> awesome
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15:29 < fenn> redlegion: and what was your thoughtcrime that got you chemically fixated?
15:36 < fenn> .title https://www.theverge.com/2022/4/2/23007575/russia-suspend-iss-cooperation-sanctions-lifted-ukraine-space-nasa
15:36 < saxo> Russia says it will suspend ISS cooperation until sanctions are lifted - The Verge
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19:12 < lsneff> Can’t decide on ML or space stuff again.
19:56 < maaku> redlegion: I'm lucky I've never been hit with tolerance issues, but the side effects are killer
19:57 < maaku> lsneff: not ML. don't join a field at peak hype
19:58 < maaku> (says the blockchain engineer, lol)
20:03 < maaku> lsneff: I was perscribed medication on my first visit with a psychiatrist, so it could be pretty quick
20:04 < maaku> would probably be much slower if you go through insurance
20:05 < maaku> shout out to my doc who is really good : https://www.silverlakeadhd.com
20:31 < jrayhawk> more honest article title: "russian leadership pretends the shutdown of space program is by choice"
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--- Log closed Mon Apr 04 00:00:45 2022