--- Log opened Thu Apr 14 00:00:54 2022
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07:40 < kanzure> "Chemical reprogramming of human somatic cells to pluripotent stem cells" https://www.nature.com/articles/s41586-022-04593-5
07:40 < kanzure> yashgaroth: ^
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08:08 < yashgaroth> scihub doesn't seem to have it so I can't get too in depth, but I don't see the immediate benefit over just using the yamanaka factors. If they'd claimed higher efficiency or faster reprogramming then that would've been in the abstract, but introducing OSKM transcription factors isn't the hard part, especially for any lab growing PSCs
08:10 < yashgaroth> certainly it's noteworthy that they are helping ~elucidate~ the pathways leading to reprogramming, and could make the process more reliable in the future
08:14 < yashgaroth> unless some crypto billionaire funds another $100m longevity startup based around it, yes it's easier to expose difficult cells in the body to small molecules than to intracellularly-active proteins, but good luck balancing the PK/PD for a dozen chemicals while trying to avoid supercancer
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--- Log closed Fri Apr 15 00:00:55 2022