--- Log opened Thu May 12 00:00:21 2022
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04:32 < kanzure> https://github.com/aws/aws-fpga
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11:20 < fenn> food prices going up, just like jaydugger predicted http://www.nytimes.com/2022/04/30/world/europe/cooking-oil-shortage-ukraine.html
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11:40 < kanzure> https://www.deepmind.com/publications/a-generalist-agent
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11:41 < lsneff> I think everyone predicted that food prices would continue to rise
11:47 < kanzure> "Proof-carrying data from accumulation schemes" https://eprint.iacr.org/2020/499
11:47 < kanzure> "Halo Infinite: Recursive zk-SNARKs from any additive polynomial commitment scheme" https://eprint.iacr.org/2020/1536
11:47 < kanzure> "Proof-carrying data with succinct arguments" https://eprint.iacr.org/2020/1618
11:51 < kanzure> er, without succinct arguments
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14:00 < L29Ah> https://www.daniclodedesign.com/thethirdthumb
14:22 < kanzure> interesting combo: https://github.com/alufers/mitmproxy2swagger + https://github.com/ioxiocom/openapi-to-fastapi + https://github.com/koxudaxi/fastapi-code-generator
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14:35 < kanzure> why did it turn out that the hippocampus was so easy to simulate? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395724/
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14:51 < kanzure> "Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan" https://www.biorxiv.org/content/10.1101/2022.05.11.491574v1
15:19 < docl> .tw https://twitter.com/longevion/status/1524841585627779082
15:20 < saxo> Now @aubreydegrey and @CharlesMBrenner agree a lot more than usual 👀 https://twitter.com/i/spaces/1LyxBoyzQnpKN (@longevion)
15:20 < docl> follow up convo to this: https://rss.com/podcasts/letstalklongevity/
15:21 < kanzure> https://portswigger.net/daily-swig/nvidia-hackers-allegedly-attempting-to-blackmail-company-into-open-sourcing-gpu-drivers
15:22 < kanzure> https://developer.nvidia.com/blog/nvidia-releases-open-source-gpu-kernel-modules/
15:31 < kanzure> .tw https://twitter.com/briankrebs/status/1506754458008670209
15:31 < saxo> Experts say the LAPSUS$ data extortion group that hit Okta and Microsoft this week is run by a 17-year-old from the UK who recently bought the Doxbin doxing website, and then leaked its database. Naturally, Doxbin responded by doxing the LAPSUS$ leader. https://krebsonsecurity.com/2022/03/a-closer-look-at-the-lapsus-data-extortion-group/ (@briankrebs)
15:35 < kanzure> https://krebsonsecurity.com/2022/03/a-closer-look-at-the-lapsus-data-extortion-group/
16:08 < kanzure> orion's arm discord server https://discord.gg/gcBKANv
16:18 < kanzure> "Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity" https://www.pnas.org/doi/pdf/10.1073/pnas.2112812119
16:20 < kanzure> that's a cool review.
16:26 < kanzure> "Figure 4. DNA Polymerase Activity Sensor. A phi29 DNA polymerase is conjugated to the sensor bridge using the SpyTag-SpyCatcher conjugation scheme The 25-second-long signal trace shows an isolated burst of sensor activity that occurs after adding a primed 40-mer template (sequence 5'-25T 15G-3') and corresponding (dCTP and dATP) nucleotides. The expectation is the polymerase would acquire a ...
16:26 < kanzure> ...template and incorporate 15 C's followed by 25 A's. A series of ~40 discrete major pulses are seen, representing putative incorporation events. The signal trace has ~15 wide-spaced, narrower pulses on the left (green region), and ~25 closely spaced, broader pulses on the right (red region), suggesting these are the C and A events, respectively, and that therefore the C and A incorporations ...
16:26 < kanzure> ...events can be distinguished by examining pulse features."
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16:36 < kanzure> need an excuse to try https://github.com/pyscript/pyscript
16:49 < kanzure> .tw https://twitter.com/CharlesMBrenner/status/1524889256698687489
16:49 < saxo> @kanzure @Nature @Cell_Onion Bryan's dystopian mouse colony.... (@CharlesMBrenner, in reply to tw:1524888117240553473)
16:50 < kanzure> bah
16:51 < docl> biomolecular factory on a chip is an awesome idea, I'm becoming increasingly convinced
16:52 < docl> picturing an implant that can synthesize precise doses of any drug, hormone, etc
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16:54 < docl> downloadable vaccines for the latest virus. wouldn't want to leave this connected to the internet often though
16:54 < kanzure> i am thinking immobilized ribosome between nanoelectrodes in a gap junction, use various forcs to manipulate operation of 30 nm (or larger) ribosomal units 
16:55 < kanzure> for nanomanufacturing purposes
16:55 < kanzure> DNA synthesis is important and useful but we can also get pretty far if we just have programmable real-time control over ribosome
16:55 < docl> very true
16:55 < mlaga97> docl gives a whole new purpose to those antivirus popups
16:55 < docl> yeah...
16:56 < kanzure> docl: are you familiar with the george church proposal for recoding mammalian genome with new codons so that natural viruses are incapable of hijacking cell machinery
16:56 < docl> no, hadn't seen it
16:56 < kanzure> it's on our wiki somewhere
17:00 < docl> precision biomolecular dosing with an implanted chip factory would be capable of a lot of things ranging from birth control to mind control. security would be even more paramount than usual
17:01 < docl> er chip based factory, not factory of chips
17:01 < kanzure> docl: https://gnusha.org/logs/2016-09-17.log near the facebook link
17:01 < kanzure> wait, wrong reference
17:01 < kanzure> you want in vivo drug manufacturing and downloadable drugs, not organoid simulation chip factory
17:02 < docl> right
17:02 < kanzure> well i think the logs go on to discuss in vivo drug synthesis
17:03 < docl> I can't be the first to think of something like that... fits neatly with your electronic polymerase ideas, although in principle everything could be done stepwise
17:03 < kanzure> downloadable anti-virus more practical with on-chip oligonucleotide synthesis than enzymatic dna synthesis :(
17:14 < lsneff> Before in vivo, if you can set up a programmable ribosome to synthesize drugs in general, that’d change the world
17:14 < docl> true
17:16 < docl> kanzure: you mention downloadable antivius later in the same chat, good points imo
17:25 < docl> can memory chips be used to guide reactions? maybe with very small amounts of fluid involved, you could guide molecular collections through a series of reactions with the surface voltage changes?
17:41 < lsneff> Electrode arrays aren’t hard to make with semiconductor manufacturing tech
17:55 < kanzure> docl: sounds like OWED stuff.
17:56 < kanzure> SCOEW, rather
17:56 < kanzure> ttps://gnusha.org/logs/2021-02-11.log
18:01 < docl> ah yeah, electrowetting or maybe optoelectrowetting
18:01 < docl> .wik Electrowetting
18:01 < saxo> "Electrowetting is the modification of the wetting properties of a surface (which is typically hydrophobic) with an applied electric field. /  The electrowetting of mercury and other liquids on variably charged surfaces was probably first explained by Gabriel Lippmann in 1875 [...]" - https://en.wikipedia.org/wiki/Electrowetting
18:05 < docl> it links to e-paper. maybe an e-paper display is usable as a lab if you switch out the ink
18:06 < docl> https://en.wikipedia.org/wiki/Electronic_paper#Electrowetting
18:09 < docl> hmm. if you can shock a ribosome into doing whatever you want with nanoelectrodes you might not really need stepwise mfg
18:23 < muurkha> lsneff: depends on what you mean by "electrode arrays"
18:55 < docl> .t https://pubmed.ncbi.nlm.nih.gov/20448870/
18:55 < saxo> Single-sided continuous optoelectrowetting (SCOEW) for droplet manipulation with light patterns - PubMed
18:55 < docl> "The unique lateral field-driven optoelectrowetting mechanism also enables extremely low light intensity actuation, and droplet manipulation can be achieved by directly positioning the SCOEW chip on a LCD screen used in a laptop or portable cellular phone. "
18:59 < kanzure> i am going to be hosting a workshop on open-source silicon chip design for hardware wallets and trusted computing, here's some information about attending https://www.blockchaincommons.com/salons/silicon-salon/
18:59 < kanzure> (let me know privately if any of you would need or like one of the freebie invites)
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19:36 < lsneff> kanzure: do you have any literature on that ribosome idea?
20:12 < docl> SCOEW paper http://diyhpl.us/~bryan/papers2/microfluidics/Single-sided%20continuous%20optoelectrowetting%20(SCOEW)%20for%20droplet%20manipulation%20with%20light%20patterns%20-%20LCD%20-%202010.pdf
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23:33 < nsh> .t https://physicsworld.com/a/quantum-error-correction-makes-its-zero-magnetic-field-debut/
23:33 < saxo> Quantum error correction makes its zero-magnetic field debut – Physics World
--- Log closed Fri May 13 00:00:21 2022