--- Log opened Sat May 25 00:00:05 2024
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11:16 < hprmbridge> alonzoc> Full colour eink display at 60hz would be awesome. I could see it as a better replacement for smart  whiteboards as well even at a lower refresh rate
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14:34 < fenn> .t https://www.science.org/doi/10.1126/science.adl0984
14:34 < saxo> Just a moment...
14:35 < fenn> ^ crows have vocalisations for numbers and count out loud
14:37 < fenn> @Eli "I can post a link if it's allowed in the channel?" sure, it seems topical
14:37 < fenn> can't promise i'll watch everything, but 5 mins is pretty easy
14:51 < fenn> neuralink update: "Just four months ago, Noland Arbaugh had a circle of bone removed from his skull and hair-thin sensor tentacles slipped into his brain. But as weeks passed, about 85 percent of the device’s tendrils slipped out of his brain. Neuralink’s staff had to retool the system to allow him to regain command of the cursor. Though he needed to learn a new method to click on something,
14:51 < fenn> he can still skate the cursor across the screen."
15:42 < kanzure_> https://x.com/patrissimo/status/1794493623947403750
16:33 < fenn> .m
16:34 < fenn> "I've been asked by a number of people for my thoughts on the @MinicircleDNA  skepticism piece ..."
16:36 < fenn> "The only intervention I've ever done that's even close to comparable is taking amphetamines."
16:38 < fenn> "I love living in an age that produces inventions so awesome that it’s hard to believe they could be real."
16:39 < fenn> what does he mean by "eagerness to get back to Próspera & get my reversal reversed ASAP"
16:50 < hprmbridge> kanzure> yashgaroth covered the "reversal" tech in his writeup
16:58 < hprmbridge> alonzoc> We're really doing well for snakeoil  biotech atm aren't we. Minicircle and the anti tooth decay probiotics
16:59 < hprmbridge> alonzoc> Maybe I should start a company that sells probiotic supplements that produce myostatin inhibitors or just garden variety anabolic steroids
17:00 < hprmbridge> kanzure> "hmm we seem to have a fraud problem. oh! I should also do me a fraud!"
17:07 < hprmbridge> alonzoc> (Just for disambiguation that was supposed to be sarcasm)
17:07 < fenn> alonzoc is there a reason to think the caries vaccine is not effective?
17:09 < fenn> personally i'm not worried about developing mutacin antibiotic resistance because it's not a drug in the first place
17:09 < hprmbridge> kanzure> https://trevorklee.substack.com/p/please-dont-take-luminas-anticavity?ref=MIRIbunker7
17:09 < fenn> yeah i read that article and it's a bunch of shit
17:09 < fenn> don't waste my time with that level of discourse
17:12 < hprmbridge> alonzoc> I can't say much on the actual effectiveness but just releasing antibiotic producing probiotics is a bad plan. Constant long term production of antibiotics is not ideal and I do worry about the selection for resistance because it quickly becomes a slippery slope
17:15 < fenn> antibiotic production is a common feature of bacteria in general. it's a warzone out there, and in there, and everywhere
17:16 < fenn> the original mutacin producing strain was isolated from a grad student's mouth
17:17 < fenn> here's an article on the technology from long ago https://www.sciencedirect.com/science/article/abs/pii/S0167779903000854
17:18 < hprmbridge> alonzoc> Yeah, but we don't need to have humanity pushing the pedal and increasing selection pressures. Mutacin resistance can evolve and you need to revise your probiotic.
17:18 < hprmbridge> alonzoc>
17:18 < hprmbridge> alonzoc> It's solving a problem which can be solved by much more minor and less involved solutions. If it effective it's massively over engineering vs standard dental hygiene.
17:18 < hprmbridge> alonzoc>
17:18 < hprmbridge> alonzoc> Also iirc there's some good work from regenerative medicine on growing new teeth. Which I would prefer as a solution, repair or regrow. Don't fight a battle that's been going on for millennia
17:20 < hprmbridge> alonzoc> Slight correction; don't fight a battle that's been going on for millennia if you have other options. Defending against bioweapons etc is a necessary fight
17:20 < fenn> it hasn't been going on for millennia. tooth decay is mostly caused by modern diets, not just sugar and potato chips but also pasteurized milk, lack of vitamin K
17:21 < fenn> "standard dental hygiene" only works for some people
17:22 < fenn> also amphetamines cause tooth decay
17:22 < hprmbridge> alonzoc> The "millennia" is in reference to antibiotics and antibiotic resistance
17:22 < fenn> billions of years then
17:22 < hprmbridge> alonzoc> Huh? can I have references on the amphetamines? Not questioning it but curious
17:23 < fenn> it causes dry mouth, and saliva carries IgA which tends to stop tooth decay
17:23 < fenn> .wik meth mouth
17:23 < saxo> "Meth mouth is a colloquial term used to describe severe tooth decay and tooth loss, as well as tooth fracture, acid erosion, and other oral problems that are often symptomatic to extended use of the drug methamphetamine.  The condition is thought to be caused by a [...]" - https://en.wikipedia.org/wiki/Meth_mouth
17:26 < hprmbridge> alonzoc> Lovely... Glad I don't use amphetamines medically nor recreationally
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17:36 < jrayhawk> there's a 2-3 order of magnitude difference between typical medical and recreational dosages with concomitant difference in dry mouth symptoms
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17:41 < jrayhawk> and also 2-3 order of magnitude differences in appetite suppression (i.e general lean mass loss i.e. odontoblast suppression) and stress behaviors such as teeth grinding
17:42 < fenn> good to know
17:46 < jrayhawk> the MAO-B inhibitors in an undercooked clove of garlic, for instance, cause *way* more drymouth for me than medical doseages of stimulants ever have
17:56 < jrayhawk> along with the things you mentioned, muscle-as-endocrine-organ should also be mentioned as a going concern for nerds and dental health
17:57 < jrayhawk> https://scholar.google.com/scholar?q=igf-1+odontoblast
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--- Log closed Sun May 26 00:00:06 2024