--- Log opened Mon Jun 03 00:00:13 2024
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08:55 < hprmbridge> kanzure> deming's cryonics startup https://www.cradle.xyz/page/whitepaper-i
08:57 < hprmbridge> kanzure> https://twitter.com/LauraDeming/status/1797641862309937627
09:00 < geneh2> there's no upper limit to math that can find practical use in robotics and control
09:02 < geneh2> even rational trigonometry has some use. Rational trigonometry is trigonometry without real numbers developed by a finitist mathematician.
09:03 < geneh2> That being said, I think a great way to learn about controlling robots is to build them in simulation. If you can't get it to work in sim, it's going to be even more difficult IRL
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10:19 < hprmbridge> kanzure> https://www.bloomberg.com/news/articles/2024-06-03/cryogenic-freezing-finds-new-hope-from-cradle-healthcare?accessToken=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJzb3VyY2UiOiJTdWJzY3JpYmVyR2lmdGVkQXJ0aWNsZSIsImlhdCI6MTcxNzQyMTU5NSwiZXhwIjoxNzE4MDI2Mzk1LCJhcnRpY2xlSWQiOiJTRUk5R0lEV0xVNjgwMCIsImJjb25uZWN0SWQiOiI5MTM4NzMzNDcyQkY0QjlGQTg0OTI3QTVBRjY1QzBCRiJ9.TbMaEaVctBZC9ho_J9ErzIcdIZE-jY724cHkctvg7H8
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17:03 < fenn> "As of February 2024, we’re excited to announce that we’ve recovered electrical activity in a cryopreserved and rewarmed slice of rodent neural tissue"
17:04 < fenn> is that actually new? i thought there was a re-warmed dog that derped around for a few minutes before dying
17:04 < fenn> why the sapphire tissue sandwich?
17:07 < fenn> "This is, to our knowledge, the first demonstration of action potentials in cryopreserved and rewarmed acutely resected neural tissue."
17:08 < kanzure> small cell cryopreservation was already a thing right? so where does the other $48m come from?
17:12 < fenn> from being laura deming
17:15 < fenn> https://www.longevity.vc/
17:17 < fenn> i've actually never heard of any of the companies in this portfolio, with the exception of conception.bio
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17:20 < fenn> i'd argue that "Increasing healthy human lifespan with a drug is the most important milestone" is completely wrong
17:21 < fenn> it's going to take many years to get any feedback on that metric, and by that time you're halfway dead. better to focus on things that improve health metrics by plausibly reversing aging
17:21 < fenn> we aren't interested in increasing lifespan by a few percent, so anything with less than spectacular results is a complete waste of time
17:22 < fenn> so measure the health metrics directly, not lifespan
17:23 < fenn> focus research interventions on the root mechanisms of aging pathology
17:23 < hprmbridge> kanzure> even if programmed aging is false, at this point I think advocating for solely programmatic interventions might be warranted
17:23 < hprmbridge> kanzure> to bypass all the small molecule miracle drug worship
17:24 < hprmbridge> kanzure> or supplement frenzy
17:24 < fenn> is there a proof of concept whole organism rejuvenation with OSK yamanaka factors?
17:24 < hprmbridge> kanzure> with or without cancer?
17:25 < fenn> either
17:29 < fenn> another metzger
17:29 < fenn> .t https://www.biorxiv.org/content/10.1101/2023.01.04.522507v2
17:29 < saxo> Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice | bioRxiv
17:29 < fenn> "systemically delivered AAVs, encoding an inducible OSK system, in 124-week-old mice extends the median remaining lifespan by 109% over wild-type controls and enhances several health parameters. Importantly, we observed a significant improvement in frailty scores indicating that we were able to improve the healthspan along with increasing the lifespan."
17:30 < fenn> womp womp
17:31 < fenn> so 124 week old mice lived to 134 in the control group, and 144 in the intervention (roughly)
17:32 < fenn> i wish they had tried it on mice of varying ages
17:37 < fenn> "is it possible to reverse cellular aging in vivo without causing uncontrolled cell growth and tumorigenesis? Initially, it didn’t seem so, as mice died within two days of expressing OSKM. But work by the Belmonte lab, our lab, and others have confirmed that it is possible to safely improve the function of tissues in vivo by pulsing OSKM expression or by continuously expressing only OSK,
17:38 < fenn> leaving out the oncogene c-MYC"
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21:47 < fenn> the AI wars are already getting started https://www.aria.org.uk/programme-safeguarded-ai/
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--- Log closed Tue Jun 04 00:00:14 2024