--- Log opened Wed Jun 19 00:00:28 2024
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05:03 < kanzure> saying "it's holographic" is not helpful, make me a hologram decoder
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06:55 < nsh> you just used one
06:55 < nsh> presumably you imagine you'd like to read it into something it isn't
06:55 < nsh> ie classical data
06:55 < nsh> i'm not sure this is a good idea :)
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07:59 < kanzure> it's a great idea
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08:45 < hprmbridge> nmz787> It wouldn't be as compact
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15:17 < faceface> hihi
15:17 < faceface> Anyone want to attend a biohackathon in the UK in October?
15:21 < faceface> https://manifesto.biohackathon.xyz/
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19:54 < hprmbridge> kanzure> "Peptide sequencing via reverse translation of peptides into DNA* https://www.biorxiv.org/content/10.1101/2024.05.31.596913v1
19:55 < hprmbridge> kanzure> "We employ a modified Edman degradation process that converts peptides into DNA-barcoded amino acids, which are subsequently detected by proximity extension assay, yielding multi-barcoded DNA outputs that can be PCR amplified and sequenced. Using our method, we sequenced multiple consecutive amino acids within a model peptide. This method also enables the differentiation of single amino acid
19:55 < hprmbridge> kanzure> substitutions, and the identification of post-translational modifications and their positions within multiple peptides simultaneously. With further development, we anticipate that this method will enable highly parallel de novo protein sequencing with single-molecule sensitivity."
19:55 < hprmbridge> kanzure> https://twitter.com/JuliaBauman2/status/1803554167467942104
19:56 < hprmbridge> kanzure> here's a much older method with a cool uspto code https://patents.google.com/patent/US20030100000A1/en
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20:39 < hprmbridge> geraldmahony> Wow
20:39 < hprmbridge> geraldmahony> The power of DNA templated processes
20:40 < hprmbridge> geraldmahony> There's like 4 people on the author list lol
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21:58 < fenn> reaffirming how awesome it is to have a no-philosophy rule
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--- Log closed Thu Jun 20 00:00:29 2024