--- Log opened Sat Jul 13 00:00:51 2024
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09:48 < hprmbridge> nmz787> Pretty sure Vyvanse would turn me into a never-sleeping zombie. Amphetamines seem to affect me strongly for a lonnnnng time. So much that I pretty much gave up getting my prescriptions of dextro because it was just too disruptive to sleep
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09:59 < L29Ah> how much did you take and at what time of day?
10:01 < hprmbridge> nmz787> It's been more than a decade since I gave up getting a prescription filled every month for dextro, but I'm guessing 5mg-10mg
10:01 < hprmbridge> nmz787> Time was probably 8am plus minus an hour
10:02 < hprmbridge> nmz787> Maybe it was psychosomatic/placebo, but I felt like at midnight I could still feel it influencing me enough to disrupt sleep. I generally tend to stay up late if I'm not careful about forcing myself to slow down.
10:41 < docl> https://foresight.org/ext/ForesightNanotechTree/
10:47 < docl> nothing about spiroligomers, must not be very complete. might be some good lit refs though
10:49 < docl> ah, bottom-up nanotechnology links to one of drmeister's talks
10:53 < docl> https://www.youtube.com/watch?v=yQ09nW8UhU4 // C. Schafmeister | Hardware and Software of a Critical Path to Bottom-up Molecular Nanotechnology
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11:14 < docl> worth watching/rewatching
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11:40 < docl> wrt aldehyde fixation reversal, my current understanding is that (unlike the glucosapene crosslinks he mentions which involve a few specific long-lived structures), glutaraldehyde crosslinks are less specific and you'd need a ton of different specialized spiroligomers to get all of them. still, seems like it might be more plausible with the smaller enzymes possible with spiroligomers vs natural proteins
11:40 < superkuh> https://www.isaaa.org/gmapprovaldatabase/ - list of genetically modified crops approved for use in various countries
11:41 < fenn> glucosepane
11:41 < docl> darn it, I tried to google the spelling
11:42 < docl> this article misspells it like I did https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276923/
11:43 < docl> .wik Glucosepane
11:43 < saxo> "Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. It is an irreversible, covalent cross-link product that has been found to make intermolecular and intramolecular cross-links in the collagen of the [...]" - https://en.wikipedia.org/wiki/Glucosepane
11:44 < fenn> why not just use a long molecule so a big enzyme can get in there and go chop chop
11:46 < docl> I sort of assume the small molecule fixing more stuff is an advantage for preservation
11:47 < docl> but maybe it's overkill to use something that small
12:15 < docl> (my argument wrt the glutaraldehyde being so nonspecific that you need to sense context to target it is kind of ungrounded, I might be wrong)
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13:34 < hprmbridge> kanzure> https://transhumanaxiology.substack.com/p/ice-the-penultimate-frontier
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19:05 < docl> I like the ice continent idea. I wonder if there are cheaper ideas in the adjacent space than the $20M/km^2 price tag. Apparently the ice itself is not that expensive.
19:16 < docl> hmm. if it's cold/dry enough, you can probably spray seawater into the air to make snow (mixed with salt). in a certain temperature range, my guess is the salt tends to mely part of the ice, making brine which flows back into the sea. so cheap platforms of ice might be possible cheaper than reverse osmosis
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--- Log closed Sun Jul 14 00:00:52 2024