--- Log opened Thu Jul 18 00:00:56 2024
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05:40 < kanzure> hmph
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06:17 -!- Topic for #hplusroadmap: biohacking, nootropics, transhumanism, open hardware | this channel is LOGGED: http://gnusha.org/logs | https://diyhpl.us/wiki | not quite sponsored by george church | banned by the MIT media lab and the FDA
06:17 -!- Topic set by fenn [~fenn@user/fenn] [Fri Mar 25 06:29:19 2022]
06:17 -!- Irssi: #hplusroadmap: Total of 66 nicks [1 ops, 0 halfops, 0 voices, 65 normal]
06:17 -!- mode/#hplusroadmap [+v gnusha] by ChanServ
06:17 -!- Channel #hplusroadmap created Wed May 19 06:51:36 2021
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10:26 < L29Ah> .t https://pubmed.ncbi.nlm.nih.gov/39020175/
10:26 < saxo> Inhibition of IL-11 signalling extends mammalian healthspan and lifespan - PubMed
11:13 < hprmbridge> Eli> ```Inhibition of IL-11 increased lifespan in both male and female mice. The magnitude of lifespan extension remains to be fully determined but current data suggest that anti-IL-11 therapy given in late life increases median lifespan by more than 20% in both sexes. In these experiments, anti-IL-11 was injected in mice from 75 weeks of age (human equivalent to approximately 55 years of age) and it
11:13 < hprmbridge> Eli> remains to be seen whether administration to older mice has similar effects and/or if short term anti-IL-11 therapy is effective for lifespan extension, as seen for rapamycin. Mouse mortality in old age is often cancer-related44 and our end-of-life autopsy data support the notion that inhibition of IL-11 significantly reduces age-related cancers. Of note, IL-11 is important for tumorigenesis and
11:13 < hprmbridge> Eli> tumour immune evasion and clinical trials of anti-IL-11 in combination with immunotherapy to treat cancer are planned22.```
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11:17 < hprmbridge> Eli> 20% is pretty impressive and seems like it would suck a lot less than CR for your entire adulthood. Definitely worth replicating and testing in different organisms as well as different strains of mice, and with the treatment given at different ages.
11:18 < hprmbridge> Eli> In fact, the results seem too good to be true. 20% lifespan extension, less cancer, bigger muscles? Why should we believe this to be possible with no side effects?
11:22 < hprmbridge> Eli> Unless we assume antagonistic pleiotropy, what would be the teleological reason this is a free lunch?
11:36 < L29Ah> perhaps impacts resistance to infectious diseases
11:37 < L29Ah> > activation of STAT3 by IL-11 is mandatory to allow regeneration and to prevent injury-induced fibrotic remodeling and scar formation
11:39 < L29Ah> https://en.wikipedia.org/wiki/Interleukin_11 plenty of fun eh
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14:11 < hprmbridge> Eli> That
14:11 < hprmbridge> Eli> thats what I'm
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16:19 < hprmbridge> abcedarius> Re the Antarctic wall I had that same thought a few months ago. Odd coincidence
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17:53 < fenn> "inhibition of IL-11 significantly reduces age-related cancers" ok what's the downside?
17:54 < fenn> less energy stored in fat for the winter?
17:56 < fenn> "Transforming growth factor β1 (TGFβ1) through up-regulation of IL-11, stimulates collagen production and is important in wound healing."
17:56 < fenn> and maybe you'll bleed out without enough platelets to clot
18:03 <+gnusha> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=380ff1fa fenn: interleukin-11 inhibition >> http://diyhpl.us/diyhpluswiki/longevity/interventions/
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--- Log closed Fri Jul 19 00:00:57 2024