--- Log opened Sun Jul 28 00:00:06 2024
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09:47 < alethkit> Are dully synthethic cells the cloest thing we have to a genome compiler, or do they require more steps than "turn DNA intro chromosones, insert into cell, let mitosis happen"?
09:47 < alethkit> (Signed, a computer scientist who wishes biology were less complicated)
09:48 < hprmbridge> kanzure> depends on what you mean by genome compiler
09:48 < hprmbridge> kanzure> not all cells have chromosomes btw, that's how the mycoplasma minimal cell was made
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13:03 < hprmbridge> Eli> If big pharma could sell personal responsibility in a pill it would eliminate 50% on the medical industrial complex.
13:13 < nsh> per ardua ad astra
14:34 < alethkit> Eli: isn't that what semaglutide (and the ADHD pills, to some extent) do?
14:38 < alethkit> (are there any hybrid organisms between viruses and prokaryotes? )
14:39 < alethkit> (so something that requires bootstrapping from another cell, but can then reproduce on its own)
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14:59 < hprmbridge> kanzure> alethjit, have you read about venter's minimal cell?
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22:11 < hprmbridge> Eli> Semaglutide could have a massive impact on western society, even beyond just the healthcare system. So, yes, for those it works for it can be incredible.
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23:00 < jrayhawk> I don't see how.
23:07 < jrayhawk> Exactly as one expects from the equation of "energy stores are regulated to meet the needs of Y lean mass for X days, where X controlled by inflammatory cytokine levels as a measure of how much trouble the body is in", when you force a decrease in energy storage without doing anything about the cytokines, you force the downregulation of lean mass 
23:07 < jrayhawk> https://link.springer.com/article/10.1007/s00125-019-05065-8
23:08 < jrayhawk> taking sick people and removing adipose tissue does not make for healthy people, it makes for weak sick people https://www.omgwallhack.org/home/jrayhawk/hidden/weight/Association_Of_Weight_Status_With_Mortality_In_Adults_With_Incident_Diabetes.pdf
23:08 < jrayhawk> https://www.omgwallhack.org/home/jrayhawk/hidden/weight/Keith_Norris_Scale_Weight.mp4
23:37 < hprmbridge> Eli> Yes, I strongly agree. Sleep, diet, and exercise are essential. Those on GIP receptor/GLP-1 receptor agonists especially need to get enough protein and practice resistance exercise to maintain as much lean muscle mass as possible. There's no question about that.
23:37 < hprmbridge> Eli>
23:37 < hprmbridge> Eli> I don't personally have any patients because I'm not a doctor. But from what doctors have said, some people just have to have these medications. Many of the people on the show The Biggest Loser gain all their fat back after the show is over. For people who need help resetting their satiety set point, these medications seem to give some people hope. Additionally, there will be research into other
23:37 < hprmbridge> Eli> areas. There may be benefits when it comes to getting people off addictive substances like drugs and alcohol. There's still a lot of science to do.
23:52 < jrayhawk> It is trying to use the tail to wag the dog.
--- Log closed Mon Jul 29 00:00:06 2024