--- Log opened Tue Aug 06 00:00:14 2024
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03:02 < fenn> https://arstechnica.com/science/2024/08/the-dangers-of-losing-weight-faster-than-your-doctors-can-keep-up/
03:02 < fenn> i thought this was going to be about GLP-1 side effects
03:02 < fenn> nope
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04:47 < hprmbridge> setecastronomy1891> https://www.wired.com/story/rayv-lite-laser-chip-hacking-tool/
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08:19 < hprmbridge> kanzure> infinitely long polypeptides manufactured by ribosome https://rnajournal.cshlp.org/content/4/9/1047.full.pdf (1998)
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12:48 < hprmbridge> setecastronomy1891> How do I stop persistent neuropathic pain signal
12:48 < hprmbridge> nmz787> depends on what nerves
12:49 < hprmbridge> nmz787> lidocaine or novocaine
12:49 < hprmbridge> nmz787> capsaicin is another option, but that's more like "try to hurry through the pain"
12:50 < hprmbridge> nmz787> (where hurry here is still years or neverending)
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12:51 < hprmbridge> setecastronomy1891> Eye pain
13:00 < hprmbridge> nmz787> I've heard cannabis reduces eye blood pressure, or something like that
13:00 < hprmbridge> nmz787> I suppose some sort of numbing drops (-caine stuff) might be an easy experiment
13:01 < hprmbridge> nmz787> since your eyes are normally quite protected, I don't think sensation loss would be too worrisome
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16:21 < hprmbridge> Eli> You go to the doctor and figure out what’s wrong. If you have a choroid rupture or something you need to know
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20:09 < docl> it occurs to me that a kombucha scoby could be innoculated with a methanotroph. since it already fixes nitrogen, you could go straight from natural gas to protein that way
20:12 < docl> you need 500 ppm to get Methylotuvimicrobium buryatense 5GB1C to work, but we're talking about a solution with ethanol in it so it might be soluble enough. also the cellulosic biofilm tends to trap gas
20:15 < docl> the main issue might be that kombucha tends to be relatively low pH
20:19 < docl> ah, I found a ref saying M. buryatense is alkaliphilic. so that won't work
20:23 < hprmbridge> nmz787> For what? Growing stuff on Jupiter?
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20:27 < docl> am more just thinking cheap protein
20:28 < docl> like, there's 3 orders of magnitude between the cost of protein and the cost of natural gas
21:32 < fenn> we need more development of reverse microbial fuel cells. there are microbes e.g. geobacter that grow protein "wires" to connect to redox active particles in the environment and drain the particles of energy like a battery, which drives their life processes
21:33 < fenn> methanotrophs are a good first step but it really makes no sense to insert a bunch of inefficient bulk chemistry steps into the process
21:35 < fenn> yes you *could* use a solar panel to do electrolysis and split water into hydrogen and oxygen, and then use that hydrogen to make methane with the sabatier process, and then feed that to microbes, and then they convert it into other stuff, and eventually it charges up the cell membrane potential and generates ATP, *or* just start with the charging the cell membrane part
21:36 < fenn> mycelial biomass protein grown on rice in giant vats already covers the "cheap shitty protein" gap
21:42 < fenn> somehow they've managed to put even less useful information on the website https://www.solein.com/what-is-solein
21:44 < fenn> https://solarfoods.com/science/
21:46 < fenn> "Solein is 65-70% protein, 5-8% fat and 10-15% dietary fibers and 3-5% mineral nutrients. 100g of Solein contains 385kcal"
21:48 < fenn> it used to say what the microbe was. it seems unconscionable to me that they would withold his info from the consumer
21:48 < fenn> people need to know which organisms they're consuming, for allergy avoidance and just understanding what the hell's going on
21:51 < fenn> solar foods' Hydrocow will produce beta-lactoglobulin the protein found in whey
21:52 < fenn> from hydrogen and CO2 and water
21:57 < docl> not cheap enough, looks like
21:58 < docl> also they aren't apparently even selling it
22:00 < docl> they were bragging to the press about it 4 years ago it's not even for sale anywhere :(
22:02 < docl> https://en.wikipedia.org/wiki/Hydrogen-oxidizing_bacteria
22:03 < docl> thing is, we have lots of cheap methane
22:05 < fenn> according to the patent, the strain they're using is a Xanthobacter VTT-E-193585 derivative
22:06 < fenn> isolated from the seashore in Naantali, Finaland
22:07 < fenn> there are some 16S sequences that could help find related organisms
22:09 < fenn> they also patent using Xanthobacter: agilis, aminoxidans, autotrophicus, flavus, tagetidis, viscosus, sp. 126, sp. 91
22:09 < fenn> there is now a factory and supposedly they are selling gelato in singapore
22:10 < fenn> i don't understand why they are so many DNA sequences in this patent
22:14 < fenn> there are enough sequences here you could probably construct a functioning copy with a related microbe and a DNA printer
22:17 < fenn> it is capable of nitrogen fixation, but grow slower
22:18 < fenn> VTT did some work on methanotrophs for food protein before these guys spun out solar foods
22:19 < fenn> i think it's the same people
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--- Log closed Wed Aug 07 00:00:15 2024