--- Log opened Fri Aug 09 00:00:17 2024
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02:45 < fenn> gingery "sounds like ding-a-ling" is all i know
02:54 < fenn> .t
02:54 < saxo> Template-free RNA synthesis by Qβ replicase | Nature
02:56 < fenn> the gingery books are good for learning how to actually build something, which nobody will teach you in a school these days
02:58 < fenn> the world has changed since 1970s and there are more different bootstrapping paths available now, like hot wire CNC and lost foam, cheap chinese ballscrews and linear rail, open source machine control software and microcontrollers, metal reinforced epoxy (moglice, jb-weld) for creating precision flat surfaces from a surface plate or granite countertop
02:59 < fenn> air bearings on granite or precision cast epoxy granite is particularly interesting, not just for crappy garage stuff
03:00 < fenn> my plan was to use stewart platforms and ballscrews and eliminate the linear motion constraint element entirely
03:00 < fenn> or possibly roller leadscrews
03:01 < fenn> choice of materials depends on what you mean by bootstrapping
03:07 < fenn> at least some fraction of the concrete lathe wiki was archived https://web.archive.org/web/20180611080154/http://concretelathe.wikispaces.com/Current+Design+Drawings
03:08 < fenn> i'm rather suspicious of the lack of photos
03:22 < fenn> why don't academics put the name of the thing that they just invented into the title of the paper they wrote about the thing?
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07:44 < kanzure> https://bessstillman.substack.com/p/the-drugs-killing-dying-patients
07:48 < kanzure> firefox gets native sidebar vertical tabs https://news.ycombinator.com/item?id=41192118 https://blog.nightly.mozilla.org/2024/08/07/firefox-sidebar-and-vertical-tabs-try-them-out-in-nightly-firefox-labs-131/
07:53 < SupUser> whoa
07:54 < kanzure> only took.. a few decades.
10:06 < jrayhawk> well, there goes Opera's lifeline
10:06 < hprmbridge> kanzure> mozilla too right, what are they going to do for revenue now
10:06 < hprmbridge> kanzure> now that google can't pay them by court ruling
10:07 < jrayhawk> charge for sidebar tabs, naturally
10:07 < hprmbridge> kanzure> charge per tab
10:09 < jrayhawk> the list of dead xulrunner projects living rent-free in my head because of that missing feature: galeon 1.4, midori, k-meleon, kazehakase
10:12 < hprmbridge> kanzure> is sideberry any good?
10:14 < jrayhawk> no wait, 1.2
10:54 < L29Ah> fenn: because it wastes precious index tokens on an item that is unlikely to be used to look for the paper
10:55 < L29Ah> also novel terms are among the signs of bullshit
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15:48 < docl> am prepping to plunge back into academia. anyone have advice other than "don't"?
15:50 < L29Ah> haha papers go brrr
16:11 < docl> well the current path is to be getting a bachelor's in physics. does it make sense to start paper-maxxing as an undergrad?
17:05 < hprmbridge> kanzure> what's your goal? you can write and publish papers without school.
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19:56 < abetusk> docl, yes, paper-maxxing immediately.
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20:32 < docl> I think my goals are mostly better lab, better connections, and better incentives. I'd like to end up considered a respectable member of the scientific community as the default reaction from someone who is also generally considered to be such a thing.
20:34 < docl> abetusk: are there specific advantages / nonlinear gains to expect from this strategy?
20:39 < docl> "Producing three peer-reviewed articles plus one monograph every five or seven years or publishing the “book of the thesis” shortly after defending it are simply a matter of compliance. However, and to return to the core issue, many mentors advise new researchers to aim to publish at least one item per year."
20:39 < docl> .t https://www.timeshighereducation.com/campus/how-much-should-you-publish
20:39 < saxo> How often should academics publish? | THE Campus Learn, Share, Connect
20:46 < docl> hmm. as a 40yo with life experience, broad science background, and decent writing skills, it's probably overdetermined for me that I should publish as a junior. I'll have to bring this up with my advisor.
20:49 < docl> huh. I'd considered writing papers, of course, but not that it being unusual probably sends a comparatively strong signal of merit if you do it as an undergrad
20:54 < abetusk> docl, it's the barrier to entry
20:59 < docl> elaborate?
21:01 < abetusk> intellect and hard work are the base line, not that there's a big correlation with paper quality. The currency of academia is papers. Getting accepted to grad school from undergraduate is, at this point, almost a requirement to have some research arc that involves at least being involved in research, usually by papers. Grad school to post doc requires papers. Post doc to tenure requires papers. Funding from Universities or 
21:01 < abetusk> grants requires papers.
21:01 < abetusk> Again, papers are the underlying currency of academia. I would say 2 per year is maybe the bare minimum. As an undergrad, maybe you can get away with 1/year.
21:03 < abetusk> The frequency of papers can probably be modulated by the journal ranking, but that's not something I know a lot about
21:13 < docl> obviously number of papers isn't the thing to maximize, but 4-10 per year seems likely reasonable. trick would be getting the effort level down far enough without compromising quality.
21:15 < docl> if I publish in many different areas and only get 1 per year in my main specialty, but it's 10/year total, how does that look to the gatekeepers?
21:15 < docl> might look better to private sector people but worse to the granting agencies?
21:16 < docl> or do they tend to look at raw numbers of academic publications and citations as a key indicator?
21:17 < Hooloovoo> it very depends on what kind of job you're getting, probably
21:17 < abetusk> As a first approximation, number of papers is the metric to maximize for. Journal quality is important but normally by the time you're submitting to a journal, I suspect the ranking is reasonable enough
21:18 < Hooloovoo> I mean, if I were looking at strong research scientists for my company, I'd look at number of papers and citations on those papers
21:18 < abetusk> The trick I think most people do is to get on large collaboration papers where you're one of a laundry list of others. For smaller number authored papers, I suspect jockying for author position is done.
21:19 < abetusk> All this is my biased opinion. Don't take this advice as someone who has insider knowledge. This is my understanding from the outside
21:20 < Hooloovoo> (same, I was going to write a paper in college, but we got scooped by some dudes at defcon)
21:22 < Hooloovoo> (my field is computer engineering/security. probably very very different for other fields
21:23 < Hooloovoo> as undergrads there was no expectation to publish anything, except if you took the final elective which required it
21:23 < Hooloovoo> (I took CPU design instead)
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21:40 < abetusk> Most of the advice given about academic career is from the perspective of how it existed 50 years ago. Modern academia is not like it was 50 years ago. Papers are the metric. Having high impact papers, first authorship, publishing in high impact journals etc. are all important for an academic career but the foundation is a firehose of publishing papers
21:41 < abetusk> Unless you're a rockstar, in which case all this advice is moot. For mere mortals that want to enter academia, papers papers papers.
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22:21 < Gatuito> Any good Glutathion precursors other than Glycine?
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22:27 < fenn> whey?
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22:44 < SupUser> what's going on
22:45 < SupUser> Are they not looking at the government stuff for that? lol...
22:45 < SupUser> It's not all in a group?
23:31 < jrayhawk> both whey and eggwhites contain a high amount of glutamylcysteine, which will bypass portions of the transulfuration pathway, similar to NAC.
23:32 < SupUser> wyg plotting out?
23:32 < SupUser> I missed a bit maybe... 
23:34 < hprmbridge> Eli> Wouldn’t taking antioxidants reduce the need for glutathione resulting in higher glutathione levels or is my biochemical wrong?
23:35 < SupUser> ideological workings, sweet.
23:36 < hprmbridge> Eli> I’m not in academia but I’m looking to author a paper on a subject I’ve done a lot of work on. Does it look suss to have no other authors? I’m pretty sure I could get some phds to put their name on it. Just curious about y’all’s thoughts.
23:37 < SupUser> That was off the wall
23:37 < SupUser> if a phd doesn't clear it or steal it lol ...
23:38 < SupUser> It's not that simple of a process
23:39 < hprmbridge> Eli> I’ve spoken to some other PhDs about it. I think they won’t steal it. One is a professor. The other is a friend who won’t care cause he has over 100 papers and it wouldn’t interest him
23:40 < SupUser> Yea whatever
23:43 < hprmbridge> Eli> Actually i should just ask my buddy. I guess I just need to figure out what journal to submit it too
23:45 < SupUser> Good luck
23:45 < jrayhawk> Eli: depends on the pathway. Oxidized ascorbic acids are not particularly safe to leave around, for instance.
23:46 < jrayhawk> Polyphenols are *really* not safe to leave around even before oxidation.
23:48 < SupUser> wym by leave around
23:48 < jrayhawk> https://wholehealthsource.blogspot.com/2011/02/polyphenols-hormesis-and-disease-part-i.html https://wholehealthsource.blogspot.com/2011/02/polyphenols-hormesis-and-disease-part.html
23:49 < SupUser> lol
23:50 < SupUser> What's your interpretation of leaving them around
23:52 < SupUser> Unless you really think I should read those articles
23:52 < SupUser> blogs
--- Log closed Sat Aug 10 00:00:18 2024