--- Log opened Fri Aug 16 00:00:24 2024
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01:26 < hprmbridge> Eli> My understanding from reading a biblical scholar was that it was just an exaggeration. “How old is this guy? Oh, super old. Like 600 years old.” I feel like that’s a pretty good explanation. Try asking a hunter gatherer society the same thing. Probably get a similar answer.
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06:49 < fenn> https://r2.fluxpro.art/clzpscqys00pn12ny0uqx6pu5/2.webp
06:50 < fenn> this chimp has good trigger discipline
08:12 < kanzure> "What we are doing at btctranscripts.com is replicating Bryan Bishop. I have spent a lot of time thought about how to replicate Bryan Bishop."
08:15 < kanzure> ruh roh
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08:41 < kanzure> https://podscan.fm/
09:20 < hprmbridge> alonzoc> kanzure: the bitcoin community gonna commit IP theft on your dna and clone you
09:22 < hprmbridge> alonzoc> Okay that site is such a neat idea. I was looking into OSINT technologies as a service
09:26 < hprmbridge> setecastronomy1891> A day to God is a thousand years. It is the deep time and long arcs of Elves and Ents.
09:26 < hprmbridge> setecastronomy1891>
09:26 < hprmbridge> setecastronomy1891> Haven’t days become imperceptibly shorter over time? A day in 1942 is slightly longer than a day in 2024 - and not just because technology has reduced communication lag
09:29 < hprmbridge> setecastronomy1891> I did a deep dive into arc seconds and precession at some point and had calculated it - I remember arriving at whatever result and concluding “ok that makes sense” then never looked at it again.
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11:08 < hprmbridge> nmz787> I guess there's some tradeoff of we're being pulled closer to the sun... Thus days getting shorter. Vs the sun is getting less massive as atoms burn off into light and gravity is getting weaker? Presumably the latter is wrong else black holes wouldn't exist
11:34 < TMA> nmz787_: eh? getting closer to the sun makes the _year_ shorter. it also accelerates locking rotation with the sun which would make days _longer_ up to the limit of ifinite days long when earth faces sun with the same side always
11:39 < TMA> light is light (pardon the pun) the mass lost by radiation is not significant enough in the short term but it is nonzero hence black hole evaporation by Hawking radiation
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12:37 < hprmbridge> Eli> Donanemab got approved for Alzheimer’s. Claims to have good results somehow despite its claimed mechanism of action being the clearing of amyloid plaque. Don’t know what to make of this https://www.nia.nih.gov/news/nia-statement-donanemab-results-more-alzheimers-research-progress
12:53 < kitaleth> https://nitter.poast.org/jacobrintamaki/status/1819579008272814108
12:54 < kitaleth> https://jacobrintamakiblog.substack.com/p/refocusing
12:55 < kitaleth> https://nitter.poast.org/jacobrintamaki
12:55 < kitaleth> oops
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14:15 < hprmbridge> kanzure> https://www.longbiofellowship.org/roadmap
14:15 < hprmbridge> kanzure> https://pubmed.ncbi.nlm.nih.gov/36829757/
14:16 < hprmbridge> kanzure> "Jean Hébert, a new hire with the US Advanced Projects Agency for Health (ARPA-H), is expected to lead a major new initiative around “functional brain tissue replacement,” the idea of adding youthful tissue to people’s brains. " from Replacing Aging book
14:19 < hprmbridge> alonzoc> Correct me if i'm badly wrong on this but as there isn't a immune system in the brain viral based gene-editing tech should be actually useful for organ-wide editing of the brain
14:26 < docl> kanzure: that blog post seems to equate mammalian cell bioreactors with fermentation in general?
14:27 < docl> "Food grown from fermentation is not a good business." <-- has he never heard of sileage? we make food for cattle by fermentation all the time
14:32 < docl> I'm growing a kombucha mat in my garage on some paper, exposed to open air. I just have to keep adding water and sugar. it also grows on perlite, so I'm considering developing that into an insulated cloth type product. mammalian cells are of course a harder thing to work with
14:34 < docl> am also testing how well it grows on urine. maybe a well adapted scoby lets you do cheaper porta potty without the smell
14:56 < hprmbridge> nmz787> Silage is sort of wrap grass and forget it though. Not quite the same as liquid culture which I assume any biotechie inplies
14:56 < hprmbridge> nmz787> Implies
14:56 < hprmbridge> nmz787> But yeah technically all sorts of ethnic pickles too
15:03 < docl> biotechies are overspecializing in fundamentally expensive approaches is my gut feeling here
16:06 < docl> maybe the way to make lots of money is to turn urea into ammonium nitrate? this is in the $100/ton range so you need a lot of volume to make sense though
16:07 < docl> also kind of the reason urea is cheap is how much easier to ship/store it is
16:11 < docl> maybe I should be thinking about cellulose-> keratin with a synthetic fertilizer additive (or n2 fixing bacteria)
16:12 < docl> spider silk is a keratin
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16:58 < docl> ah, biogenic nylon might also be of interest. polyamide, quite expensive as plastics go
17:03 < docl> .t https://www.sciencedirect.com/science/article/pii/S2468025722001753
17:03 < saxo> ScienceDirect
17:03 < docl> "A sustainable process to 100% bio-based nylons integrated chemical and biological conversion of lignocellulose"
17:05 < docl> oh they're just converting it chemically
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18:09 < fenn> https://r2.fluxpro.art/clzjljo8b00bnryhbcvoth1wc/1.webp
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20:42 < hprmbridge> alonzoc> Does folistatin have impacts on tendon development?
20:43 < hprmbridge> alonzoc> I saw some stuff on prevention of scar tissue
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21:28 < fenn> jacob rintamaki has "a sinking feeling in his stomach" and needed to write six pages about it
21:29 < fenn> "i don't see a way to go from enzymes to drexlerian nanotech"
21:29 < fenn> well jacob, here's how you do it. you pretend your enzyme is a little man made out of meat, and then have him set up a blacksmith shop with hard chunks of diamond to use as a hammer and anvil
21:31 < fenn> other concerns like "what if the nanofactory has more parts than the entire global supply chain" are not real concerns
21:42 < fenn> is this what it looks like when an EA tries to do engineering?
21:43 < docl> skill issue
21:47 < fenn> maybe it's due to being surrounded with people who say shit like:
21:47 < fenn> "non-biological manufacturing *just works*"
21:47 < fenn> "We quietly built nanotechnology in a ton of areas like computing, medicine, solar, and manufacturing, I don't see much room for old-school nanotechnology to push these frontiers. Why not help these fields keep scaling?"
21:50 < docl> it's hard to understand how people like that are modeling the universe
22:59 < hprmbridge> Eli> The brain has its own immune system separated from the rest of the body by the blood brain barrier. The blood brain barrier makes it difficult for small molecules to pass through it
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23:20 < jrayhawk> Chemokine-induced endothelial permeability works on the blood-brain barrier just as it does everywhere else. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383666/
23:22 < jrayhawk> The brain *would* have its own immune system separated from the rest of the body *if* people stopped treating their bodies as agricultural garbage disposals.
23:26 < hprmbridge> alonzoc> Yeah I'm thinking viral agents injected into the brain. Rabies is fairly total iirc
23:29 < docl> .wik Chemokine
23:29 < saxo> "Chemokines (from Ancient Greek  χῠμείᾱ (khumeíā) 'alchemy' and  κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well [...]" - https://en.wikipedia.org/wiki/Chemokine
23:31 < docl> "Chemokines are found in all vertebrates, some viruses and some bacteria, but none have been found in other invertebrates."
23:32 < docl> huh, maybe eating bugs is the way after all :P
23:32 < hprmbridge> alonzoc> Mmm sounds tasty
23:33 < docl> "1α and 1β (now known as CCL5, CCL3 and CCL4 respectively) suppress HIV-1 provided the initial connection and indicated that these molecules might control infection as part of immune responses in vivo"
23:34 < jrayhawk> which is what he jiankui got arrested for
23:35 < docl> .t https://www.youtube.com/watch?v=AqyDzRvasNM
23:35 < saxo> Chemokines | Chemokine signaling | Chemokines and cancer | how Chemokines work? USMLE step 1
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23:37 < docl> ugh would be so much better if we could just use optical signalling to tell cells what to do
23:41 < jrayhawk> examples more specific to neuroinflammation are multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/30050374/ alzheimers https://pubmed.ncbi.nlm.nih.gov/35811518 https://pubmed.ncbi.nlm.nih.gov/37355891 or huntingtons 
23:42 < jrayhawk> https://www.researchgate.net/profile/Jorge-Miranda-Massari/publication/311698058_Huntington_Disease_Management_with_Metabolic_Correction_Preliminary_Findings/links/5855308c08aeff086bf90c3a/Huntington-Disease-Management-with-Metabolic-Correction-Preliminary-Findings.pdf
--- Log closed Sat Aug 17 00:00:25 2024