--- Log opened Sat Aug 17 00:00:25 2024
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14:06 < hprmbridge> kanzure> a review from 2020 on chemical protein synthesis https://pubs.acs.org/doi/10.1021/jacs.0c09664
14:11 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1274475665088974858/image0.png?ex=66c26375&is=66c111f5&hm=ad72db94eabb58cffd0af1eacc040726908deebd676c499ee061763721a6254b&
14:12 < hprmbridge> kanzure> from https://x.com/jd_pressman/status/1824701083605930097
14:18 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1274477503875911771/image0.png?ex=66c2652b&is=66c113ab&hm=a642fb043dc1521c3edf17ce48953714b11a4946db8f469924007654ed799f2a&
14:29 < hprmbridge> alonzoc> The antikythera mechanism!
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14:30 < hprmbridge> alonzoc> Seriously awesome piece of mechanical history, attempted to build one out of lego when I was younger didn't get to far
14:32 < hprmbridge> alonzoc> On the subject of mechanical computers https://www.i-programmer.info/news/82-heritage/8506-plan-28-makes-progress-in-understanding-babbages-mechanical-notation-.html
14:32 < hprmbridge> alonzoc> I followed the links to the blog posts on the notation but couldn't find any actual documentation of their reverse engineering of the notation
14:33 < hprmbridge> alonzoc>  https://cdn.discordapp.com/attachments/1064664282450628710/1274481228048896042/Ill_1_17_Flow_Notation.png?ex=66c268a3&is=66c11723&hm=ae950739596334c5f5cdcc8660ed054dad953b599f509bf0125b9bf03d47093c&
14:35 < hprmbridge> studium.dev> > ### Abstract representations emerge in human hippocampal neurons during inference
14:35 < hprmbridge> studium.dev> https://www.nature.com/articles/s41586-024-07799-x
14:35 < hprmbridge> studium.dev> > characterized the representational geometry of populations of neurons (single units) recorded in the hippocampus, amygdala, medial frontal cortex and ventral temporal cortex of neurosurgical patients performing an inferential reasoning task. We found that only the neural representations formed in the hippocampus simultaneously encode several task variables in an abstract, or disentangled,
14:35 < hprmbridge> studium.dev> format. This representational geometry is uniquely observed after patients learn to perform inference, and consists of disentangled directly observable and discovered latent task variables. Learning to perform inference by trial and error or through verbal instructions led to the formation of hippocampal representations with similar geometric properties. The observed relation between
14:35 < hprmbridge> studium.dev> representational format and inference behaviour suggests that abstract and disentangled representational geometries are important for complex cognition.
14:35 < hprmbridge> studium.dev> cool :)
14:40 < hprmbridge> alonzoc> This was posted earlier today in a server I am in. Imo there is some better work on modelling the hippocampus with parralels to modern deep learning with:
14:40 < hprmbridge> alonzoc> https://arxiv.org/abs/2112.04035 (Paper showing the connection between transformers and the TEM model)
14:40 < hprmbridge> alonzoc> https://www.sciencedirect.com/science/article/pii/S009286742031388X (Proposal of the TEM model with the goal to model hippocampal dynamics)
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14:41 < hprmbridge> alonzoc> We did a fairly quick lit review after it was posted and these papers came out on top for ML application interest
14:42 < hprmbridge> alonzoc> https://www.nature.com/articles/s41586-018-0102-6 is also fairly interesting
14:51 < hprmbridge> studium.dev> oh interesting, Ill take a look at these ones, thanks for the links
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16:49 < hprmbridge> kanzure> wei dai expressing a possible preference for low populations because easier for AI x-risk governance https://x.com/weidai11/status/1824753539693818132
16:50 < hprmbridge> kanzure> less people to question them, the better for totalitarianism I guess.
17:31 < hprmbridge> alonzoc> This is the bullshit that gives the "New world order" conspiracy theorists fodder
17:31 < hprmbridge> alonzoc> Especailly given that *somehow* EA got the ear of important people
17:39 < L29Ah> how do i get the ear of important people for Montelibero?
17:40 < hprmbridge> nmz787> Thought that was a semiconductor chip layer stack diagram at first glance
18:30 < hprmbridge> kanzure> raygun protein design https://x.com/rohitsingh8080/status/1824804143476916712 https://www.biorxiv.org/content/10.1101/2024.08.13.607858v1
18:31 < hprmbridge> kanzure> https://github.com/rohitsinghlab/raygun
18:31 < hprmbridge> kanzure> "We show that Raygun can shrink proteins by 10-25% (sometimes over 50%) while preserving predicted structural integrity and fidelity, introduce extensive sequence diversity while preserving functional sites, and even expand proteins beyond their natural size. In experimental validation, we successfully miniaturize the fluorescent proteins eGFP and mCherry to synthesize functional variants, two of
18:31 < hprmbridge> kanzure> which are smaller than 96% of fluorescent proteins reported in FPbase. Raygun's conceptual innovations in template-based protein design open new avenues for protein engineering, potentially catalyzing the development of more efficient molecular tools and therapeutics."
18:32 < hprmbridge> kanzure> would be cool to run that on venter's synthetic mycoplasma to get an even more minimal minimum genome
18:56 < fenn> wei dai doesn't know that we live in the variant timeline where humans are really large and intelligent, whereas all the other earths have 100 billion humans or more
18:56 < fenn> tiny, stupider humans
18:59 < fenn> tiny wei dai is making the same arguments there, not knowing about large wei dai
19:00 < fenn> wei xiao
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--- Log closed Sun Aug 18 00:00:25 2024