--- Log opened Mon Aug 19 00:00:26 2024
01:27 < fenn> re DFT simulation of proteins, "no, it's still unfeasible"
04:01 < kitaleth> F
04:48 < hprmbridge> kanzure> "Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells" https://journals.biologists.com/dev/article/141/22/4231/46516/Symmetry-breaking-germ-layer-specification-and
04:50 -!- flooded is now known as _flood
06:05 < kanzure> did i know about this? "The LOV domain is a small, conserved region that binds a flavin mononucleotide (FMN) as its chromophore. Upon absorption of blue light (typically in the range of 450-495 nm), the LOV domain undergoes a conformational change that leads to the formation of a covalent bond between the FMN and a conserved cysteine residue within the protein. This light-induced ...
06:05 < kanzure> ...conformational change triggers downstream signaling pathways or other cellular responses."
06:05 < kanzure> asLOV domains etc
06:39 -!- TMM [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.]
06:40 -!- TMM [hp@amanda.tmm.cx] has joined #hplusroadmap
07:30 < kanzure> "Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517788/ (2020)
14:08 -!- geneh2 [~cam@pool-173-66-187-118.washdc.fios.verizon.net] has quit [Remote host closed the connection]
15:40 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Remote host closed the connection]
15:40 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap
17:11 < hprmbridge> kanzure> "Interestingly, it has been shown that Vibrio natriegens, despite its incredibly quick doubling speed on Earth, might grow even faster in space.  A recent experiment displayed that after 24 hours of growth the Vibrio cells grown in zero gravity were 60 times denser than those grown in full gravity, possibly attributable to an extended exponential growth phase in low-gravity conditions.[17]"
19:26 < docl> An idea I have is to take a roll of that cheap plastic tube stuff they make the bags for produce at the grocery store from and use a thermal printing process to make evolution circuits. you would coat the interior with water and nutrients for microbes to grow their way through. then you'd print barriers by selectively melting the plastic in a thermal printer. so you control what channels they can grow 
19:26 < docl> through and where the divergent strains will meet up. variations in the composition of the solvents would let you apply selection pressures in a pre-programmed manner.
19:40 < docl> you'd wind it on a roll and let it sit for however long it takes the microbes to replicate their way through to the end, say a few months. along the way you can have different strains meet up and share DNA
19:40 < docl> you can also put some dyes that will be activated by various kinds of bioactivity. when it's all done, you can run it through a scanner and use it to train an AI
20:50 -!- mxz__ [~mxz@user/mxz] has joined #hplusroadmap
20:51 -!- mxz [~mxz@user/mxz] has quit [Ping timeout: 260 seconds]
20:51 -!- mxz__ is now known as mxz
20:52 -!- mxz_ [~mxz@user/mxz] has quit [Ping timeout: 264 seconds]
21:12 < docl> .m https://x.com/leecronin/status/1825728906399461457
21:12 < AugustaAva> ​twitter: <leecronin> Proof of Chemputation. https://arxiv.org/abs/2408.09171 https://video.twimg.com/amplify_video/1825728829954076673/vid/avc1/1920x1080/KiW2qrSMmMoyhDGL.mp4?tag=16
21:31 < docl> https://www.biorxiv.org/content/10.1101/2023.05.26.541695v1.full
21:32 < docl> apparently its polymerase works 4x faster than e. coli
21:32 < docl> 4000 bp/s instead of 1000 bp/s
21:33 < docl> someone should breed variants with less DNA and see if they can replicate faster still
21:34 < docl> although these people are saying that's not the limiting factor
22:23 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Ping timeout: 260 seconds]
22:57 -!- mxz_ [~mxz@user/mxz] has joined #hplusroadmap
--- Log closed Tue Aug 20 00:00:27 2024