--- Log opened Wed Aug 21 00:00:28 2024
00:12 < fenn> i know a guy in boston with IQ 173 trying to work at a dollar store
00:12 < fenn> he is a bit of a pain in the ass, but still, sheesh
00:13 < fenn> "i wanna go back to uni. major in history. war shit from 1896-1956. stupid comp sci degree is useless"
00:15 < fenn> sometimes it seems like intelligence should be listed in the DSM
00:15 < fenn> he's currently sleeping in a field behind a gas station
00:28 < jrayhawk> http://prometheussociety.org/wp/articles/the-outsiders/
00:48 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap
01:26 < fenn> is there evidence that gifted and talented programs reduce maladjustment (by raising the average intelligence of social interaction partners)
01:32 -!- dustinm [~dustinm@static.38.6.217.95.clients.your-server.de] has quit [Quit: Leaving]
01:53 -!- dustinm [~dustinm@static.38.6.217.95.clients.your-server.de] has joined #hplusroadmap
02:58 -!- fenn [~fenn@user/fenn] has quit [Server closed connection]
02:58 -!- fenn [~fenn@user/fenn] has joined #hplusroadmap
04:27 -!- TMM [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.]
04:28 -!- TMM [hp@amanda.tmm.cx] has joined #hplusroadmap
04:30 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has left #hplusroadmap []
04:36 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap
05:29 -!- etc-vi [~etc-vi@user/meow/girlchunks] has quit [Quit: nya]
05:30 -!- etc-vi [~etc-vi@user/meow/girlchunks] has joined #hplusroadmap
05:41 < L29Ah> https://www.lifespan.io/news/hiit-training-improves-cognition/
05:49 < kanzure> ArticleGalaxy https://news.ycombinator.com/item?id=41303767
05:50 < hprmbridge> alonzoc> L29Ah: Do we have any evidence the anerobic component of HIIT is causally significant?
05:52 < L29Ah> alonzoc: i don't recall such evidence; moreover, both near-peak-aerobic and supra-aerobic regimens are called "HIIT" in different studies
05:53 < L29Ah> what if males are more of a shape-rotators because of more HIIT in their natural™ lives? // https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778720/
06:36 < hprmbridge> alonzoc> Differences is body composition probably lead to a bias as well in a kind of self fulfilling prophecy.
06:36 < hprmbridge> alonzoc> It's a pity HIIT is muddied in the literature like that as atleast in context I've discussed it it was always short intervals of high intensity anaerobic exercise until exhaustion
07:16 < kanzure> "I would imagine that having five separate enzymes might make it easier: four to add each type of base and one to add a protecting group. These would all float in solution at high concentration and activate/deactivate upon exposure/cessation to a pulse of light."
07:16 < kanzure> "I've read about light-responsive helices like AsLOV2 which can be made to "move out of the way" by stimulating with certain wavelengths. My thinking was that this kind of thing could be leveraged. Not sure if the kinetics of AsLOV2 are fast enough for this though, so that might be an obstacle.
07:16 < kanzure> "De novo design of allosterically switchable protein assemblies" https://www.nature.com/articles/s41586-024-07813-2
07:17 < kanzure> still too much diffusion in my opinion. five separate enzymes means each step requires the enzyme to find the growing strand and then attach, and the amount of time to find the strand could be quite high.
07:17 < kanzure> even fusing the five enzymes together won't necessarily make the scheme work.
07:33 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Remote host closed the connection]
07:33 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap
08:25 < hprmbridge> kanzure> wearable transcranial ultrasound https://www.biorxiv.org/content/10.1101/2024.07.17.603650v1
08:32 < superkuh> Neat.
08:54 -!- Netsplit *.net <-> *.split quits: flooded
08:54 -!- Netsplit over, joins: flooded
09:05 < fenn> if it's a single enzyme you still need the substrate to diffuse in, although you could have collection tentacles like a barnacle or hydra
09:06 < fenn> what's the alternative, four strands of each base that get swapped in?
09:07 -!- RangerMauve [m-4bpbmo@matrix.mauve.moe] has quit [Remote host closed the connection]
09:09 < hprmbridge> kanzure> well, you know what my solution is
09:09 < hprmbridge> kanzure> working on it o7
09:11 < fenn> still requires diffusion
09:12 < fenn> though maybe it's 2d-ish in that case, not sure
11:11 < hprmbridge> kanzure> Welcome @loganthrashercollins
11:12 < hprmbridge> loganthrashercollins> Hello everyone! Thank you for the invite @kanzure! (I'm assuming you are Bryan)
11:12 < hprmbridge> kanzure> yes
11:45 -!- Gooberpatrol_66 [~Gooberpat@user/gooberpatrol66] has quit [Quit: Konversation terminated!]
11:45 -!- Gooberpatrol_66 [~Gooberpat@user/gooberpatrol66] has joined #hplusroadmap
12:05 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1275893660466020433/image.jpg?ex=66c78c11&is=66c63a91&hm=38f5b6a703e9ef72722078b9635d1d14aab71ab3c54de6a4cd686be3734bea54&
12:43 -!- TMM [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.]
12:43 -!- TMM [hp@amanda.tmm.cx] has joined #hplusroadmap
12:45 < superkuh> Too bad reddit admins banned my account for asking why they banned the entire r/gundeals sub.
12:46 < superkuh> And the like. Drove away all the original users and replaced them with facebook refugees.
12:50 < L29Ah> > WhatsApp
12:51 < L29Ah> https://www.reddit.com/r/Biohackers/comments/1bewqmt/seeking_new_moderators_in_other_timezones/
12:52 < hprmbridge> kanzure> l29ah, not my screenshot
12:58 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has joined #hplusroadmap
12:58 -!- Gooberpatrol_66 [~Gooberpat@user/gooberpatrol66] has quit [Ping timeout: 245 seconds]
13:44 < hprmbridge> Eli> I think there are super strict rules on gun sales. I knew a guy who created an app specifically for gun deals because it was banned from normal online marketplaces. I don't recall if it was crypto based or how he did it.
14:00 < hprmbridge> Eli> Also, random question, is anyone a spetrophotometry expert or camera sensor expert? nmz787 I sent you a DM.
15:23 -!- RangerMauve [m-4bpbmo@matrix.mauve.moe] has joined #hplusroadmap
16:29 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Remote host closed the connection]
16:30 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap
18:27 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Ping timeout: 246 seconds]
20:48 -!- mxz_ [~mxz@user/mxz] has quit [Ping timeout: 248 seconds]
20:48 -!- mxz_ [~mxz@user/mxz] has joined #hplusroadmap
20:49 -!- mxz [~mxz@user/mxz] has quit [Ping timeout: 260 seconds]
20:49 -!- mxz_ is now known as mxz
21:33 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has quit [Quit: Konversation terminated!]
21:34 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has joined #hplusroadmap
22:02 -!- Gooberpatrol_66 [~Gooberpat@user/gooberpatrol66] has joined #hplusroadmap
22:04 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has quit [Ping timeout: 276 seconds]
22:55 -!- mxz_ [~mxz@user/mxz] has joined #hplusroadmap
--- Log closed Thu Aug 22 00:00:29 2024