--- Log opened Fri Aug 30 00:00:37 2024
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02:32 < fenn> NewtonTrendy: methylation *is* epigenomic age. that's the same thing.
02:32 < fenn> is there a component of the correlation between telomere length and epigenetic aging, that is *not* due to both of them being correlated with chronological age?
02:37 < fenn> discord has gotten really aggressively annoying in how quickly they expire uploaded image links
02:38 < hprmbridge> kanzure> how long?
02:40 < fenn> less than 2 days, not sure
02:40 < fenn> i guess i could decode "ex=66d0e011&is=66cf8e91&"
02:43 < fenn> one day exactly, just great
02:43 < fenn> so you can't run a daily cron job
02:49 < fenn> good animation on that last twitter link
02:50 < fenn> DARCARTs
02:50 < fenn> i didn't realize journals had the power to stop authors from using silly acronyms
02:52 < fenn> maybe we can hack this repetitive RNA generating system to store artificial data like cat videos
03:03 < fenn> .m https://x.com/this_clockwork/status/1820532243724689917
03:03 < AugustaAva> ​twitter: <this_clockwork> Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels I used this to make my latest video: ( https://youtu.be/lv89fSt5jBY ) ␤  ␤ But now I want to do a quick works cited 🧵 (1/ ?) https://video.twimg.com/ext_tw_video/1820511871553753088/pu/vid/avc1/1280x720/4D0V5OC3WuNofw4t.mp4?tag=12
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04:01 < NewtonTrendy> fenn: thanks for the response, im not on this, the question i was asked was: if the methylation is not increased only the the telomeres, which do effect epigenetic age, does the fact the epigenetic age is younger mean that hypermethelation can occur or no?
04:01 < NewtonTrendy> *im not clear on this.... word typo
04:08 < NewtonTrendy> heathal> can we for example grow calculators for equations like fractl like calculations, entirely in biological space yet? I see it says processor not memory etc. can we like define the problem and grow the most appropraite calculator yet?
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05:42 < hprmbridge> kanzure> fenn, yes the molecularnodes blender plugin is pretty cool, try playing around with it
06:12 < hprmbridge> kanzure> " preprint reports simple peptides with no aromatic residues at all that still exhibit fluorescence behavior"
06:14 < hprmbridge> kanzure> "Anomalous emissions from single α-helical peptides in solution"  https://chemrxiv.org/engage/chemrxiv/article-details/66c66478a4e53c48762ded6b
06:14 < hprmbridge> kanzure> https://www.science.org/content/blog-post/there-shouldn-t-be-any-there
06:15 < hprmbridge> kanzure> "All of this points to some sort of charge-transfer behavior between those alternating positively and negatively charged amino acids as the underlying fluorophore. Computational studies suggested a very strong effect of the conformation of the helix on the molecular orbital energy levels (HOMO/LUMO), and based on these, the authors tried a peptide with aromatic tyrosines every fourth residue to
06:15 < hprmbridge> kanzure> hold the conformation more steady. This showed the expected Tyr fluorescence at about 300 nM, but also a new emission shifted down to 525 nM (a nice green hue) that seems to be due to the charge-transfer network assisted by the aromatic residues, and which comes in at a rather high quantum yield (0.75). "
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07:47 < docl> huh, hanging out near the actual lab prior to the add/drop deadline and letting a professor pull you in turns out to be effective. I'm going to be starting biophysics research. likely involving the use of lysenin pores to modify cells for drug delivery.
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08:23 < kanzure> amateur watchmaking https://www.clickspringprojects.com/
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12:46 < hprmbridge> Eli> You probably should take some classes on bio and chem. Your questions aren’t making a lot of sense. Sometimes It can be difficult to make sense of academic papers and videos without a background in the basics.
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15:03 < hprmbridge> kanzure> https://www.1x.tech/discover/a-gearless-future
15:05 < fenn> humanoid robots should have muscles, not motors
15:05 < fenn> i'm surprised that magnetic gears haven't become more widespread
15:12 < L29Ah> they're heavy, have a limited torque and are quite a lot less efficient when there's metal around, IIRC
15:16 < L29Ah> unnecessarily complex to make and have a limited working temperature too
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16:41 < docl> ah, I was slightly confused, the research will be on liposomes not natural cells.
16:41 < docl> .wik Liposome
16:41 < saxo> "A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, liposomes can be used as drug delivery vehicles for administration [...]" - https://en.wikipedia.org/wiki/Liposome
16:42 < docl> not to be confused with lysosome
16:42 < docl> .wik Lysosome
16:42 < saxo> "A lysosome (/ˈlaɪsəˌsoʊm/) is a single membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that digest many kinds of biomolecules." - https://en.wikipedia.org/wiki/Lysosome
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17:43 < hprmbridge> kanzure> https://writings.stephenwolfram.com/2024/08/five-most-productive-years-what-happened-and-whats-next/
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20:52 < hprmbridge> studium.dev> https://encycloreader.org/find.php?query=ideological+turing+test&opt=ext&fulltext=0&lang=all
21:46 < NewtonTrendy> https://youtu.be/7nnLBzzQk-I?t=247
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23:05 < fenn> .t
23:05 < saxo> Wretch 32 \u0026 Avelino   FITB
23:05 < fenn> ok what is it
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23:06 < fenn> rap apparently
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--- Log closed Sat Aug 31 00:00:38 2024