--- Log opened Fri Sep 06 00:00:44 2024
00:12 < fenn> four thieves' thing just kicks the can down the road. they'll ban the precursors for the most popular diy drugs, and then we'll be back to long hairy synthesis chains that have low overall yield and require expertise
00:14 < fenn> biotech is on a much stronger footing. a few off-white spots on a piece of paper somewhere, it's much harder to police
00:17 < fenn> basically every house in america has an instant pot pressure cooker now
00:21 < fenn> it doesn't get quite hot enough to be an autoclave. maybe show incomplete sterilization of the culture media with some GFP expressing sporulating bacillus
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00:33 < fenn> huh neat. "As for the pressure cookers in this study, only the Instant Pot was able to inactivate the endospores (but required 150 minutes), making it the best choice for a laboratory pressure cooker."
00:34 < fenn> (super tough Geobacillus stearothermophilus endospores)
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03:54 < nsh> .m https://x.com/NateB_Panic/status/1831693772939227498
03:54 < AugustaAva> ​twitter: <NateB_Panic> Anarchist collective teach people how to make pirated versions of expensive pharma drugs using precursor ingredients. "A course of Solvadi, the drug by Gilead that cures Hepatitis C, costs $83,000. We made it for $70." <404media.co/right-to-repai… https://t.co/IQyBlCVNkx>
03:55 < nsh> (might be some organic chemists thereamongst, kanzure)
03:55 < fenn> the "retrosynthesis" tab in the screenshot is intriguing
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03:58 < fenn> most of the value is in just getting people to realize that DIY drug synthesis is actually an option
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06:30 < indigoman> "good sleep, good learning, good life" looks high quality. I read a bit of it last night. I'm hoping to put it to work. A little scary to not use alarm clocks and let free running sleep be the norm. Will move my exercise from the evening to the morning.
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07:26 < indigoman> I am checking logs so I will see messages sent when I am not here, btw, don't let it dissuade conversation if I disconnect
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10:00 < hprmbridge> kanzure> "Rapid discovery and evolution of nanosensors containing fluorogenic amino acids" https://www.nature.com/articles/s41467-024-50956-z
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17:50 < hprmbridge> kanzure> reflection 70b is going around, where is the open-weights leader board?
18:41 < L29Ah> .t https://www.theverge.com/2024/9/4/24235958/internet-archive-loses-appeal-ebook-lending
18:41 < saxo> The Internet Archive just lost its appeal over ebook lending - The Verge
19:09 < NewtonTrendy> does anyone have an opinion on us patent 7279327
19:13 < NewtonTrendy> im also looking for anyone clued up about how much power we are losing in our sewage system that isnt used as manure already, sorry if thats entirely offtopic, just a remark of personal character
19:18 < L29Ah> power?
19:25 < NewtonTrendy> yeah naturally its used to grow plants, theres a lot of energry in poop wasted (methane and stuff)
19:26 < NewtonTrendy> im really interested in biodigesters and their uses in powering the home and providing closed loop nutrients for personal farms
19:28 < NewtonTrendy> it probably is offtopic sorry but if anyone does want to talk feel free to contact me
19:43 < docl> probably not off topic enough to complain about on a slow day. it's biotech, after all
19:43 < L29Ah> sounds expensive at personal scale
19:44 < L29Ah> if you can somehow make a community that poops in one hole, pees in another, and dumps their dirty water into some other, it would be doable
19:49 < L29Ah> anyway, if you turn your waste into food, you have to handle the bioamplification problem; growing biodiesel would be another option, but with a more complex pipeline i think
19:51 < L29Ah> humans don't waste that much energy in poop, i'd expect something like 20W/person on a happy day; the phytonutrients are more valuable
19:54 < L29Ah> s/amplification/accumulation/
19:55 < docl> maybe you biosynthesize protein powder from it?
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22:22 < hprmbridge> Eli> That’s traditionally how humans fertilized crops. I don’t think it’s as easy as using fertilizer though. Farms in the US can be very efficient. I think they can dial in exactly how much nitrogen and water and sun they need at different times.
22:22 < hprmbridge> Eli>
22:22 < hprmbridge> Eli> Plus fertilizer doesn’t have ecoli issues
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--- Log closed Sat Sep 07 00:00:44 2024