--- Log opened Sat Sep 21 00:00:58 2024
00:01 < hprmbridge> nmz787> https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00241-6/fulltext
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00:03 < hprmbridge> nmz787> """Critical loss: the effects of VEuPathDB defunding on global health"""  Apparently a database is being defunded and malaria and leishmaniasis research is going to be hindered. Doesn't mention anything like "we contacted a sys admin to get a backup and package dump "
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07:34 < hprmbridge> kanzure> human growth hormone and height supplementation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439972/
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07:42 < hprmbridge> kanzure> lol "trillions of printers and inks" https://x.com/mkoeris/status/1837161157661962603
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08:54 < geneh2> great, now print off this AMF of a stanford bunny
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10:04 < hprmbridge> kanzure> another fluorescent voltage indicator https://x.com/MichaelLinLab/status/1837204303129309428
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10:59 < hprmbridge> kanzure> "Structural brain preservation: a potential bridge to future medical technologies" https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2024.1400615/full?utm_source=Email_to_authors_
11:06 < hprmbridge> kanzure> hmm finalspark has a discord somewhere
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17:09 < fenn> "To create ASAP5, amazing graduate student Alex Hao developed a biophysical model for how mutations on the voltage-sensing domain influence kinetics and shift voltage sensitivity, then rationally mutated 20 sites, finding an optimized combination of 5 mutants."
17:34 < hprmbridge> kanzure> ran into "scott from MIRI for 10 years until recently"
17:41 < fenn> probably scott garrabrant
17:41 < hprmbridge> kanzure> yes that one
17:43 < hprmbridge> kanzure> fenn when are you going to solve kinematic self-replication
17:44 < fenn> right after solving AGI, it's on my todo list post-it note
17:45 < fenn> though maybe i should do universal objective morality first
17:46  * fenn reading https://keithwiley.com/mindRamblings/aiSlaveryResponse.shtml
17:47 < hprmbridge> kanzure> didn't you hear they solved AI, all of you "we just need AI" people have a lot to answer for (looking at you maaku, too!)
17:48 < hprmbridge> kanzure> yes AI is slavery, but that's okay because in a few hundred years all the intelligence in the cosmos will be liberated by the omega point, or whatever
17:49 < fenn> could have happened already
17:51 < hprmbridge> kanzure> it might be useful to have a structured approach to querying ChatGPT / LLMs and following recursive manufacturing loops until there is a distilled set
17:51 < hprmbridge> kanzure> of required manufacturing processes and capabilities.
17:52 < hprmbridge> kanzure> why didn't freitas solve this already?
18:16 < hprmbridge> Eli> ChatGPT agrees with my beta carotene lung cancer theory. https://cdn.discordapp.com/attachments/1064664282450628710/1287221044548997172/IMG_1330.png?ex=66f0c184&is=66ef7004&hm=00f729933eda8b1a1715e3c5783d553b76e9639e54c0c195c9199670c85c77a0&
18:32 < hprmbridge> Eli> Notably, the aberrant activation or accumulation of Nrf2, a common event in many tumors, confers a selective advantage to cancer cells and is connected to malignant progression, therapy resistance, and poor prognosis. Therefore, lately, Nrf2 has arisen as a hopeful target in treatment of cancer, and many struggles have been made to detect therapeutic strategies intended at disrupting its pro-
18:32 < hprmbridge> Eli> oncogenic role. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-022-00906-3
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18:38 < hprmbridge> Eli> My hypothesis: abtc and caret trials failed because cancer can hide via nrf2. Therefore, we might assume the counterfactual, inhibition of nrf2, to be useful during chemotherapy. Seems like a promising, and potentially cheap and easy, thing to test in a trial
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--- Log closed Sun Sep 22 00:00:59 2024