--- Log opened Tue Oct 15 00:00:21 2024
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05:12 < kanzure> should musk's idiot index method even work? cost of raw materials is an important metric but what about energy or processing to convert the materials into a final product..?
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05:51 < jrayhawk> i think 95% of it's value is determining when a supplier is bullshitting you on price
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08:39 < kanzure> mitochondria injection https://www.mitrix.bio/
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12:01 < hprmbridge> kanzure> https://www.rapidliquidprint.com/
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14:17 < hprmbridge> Eli> I would guess they take that into account. There are people called managerial accountants who are trained to account for the cost of unfinished products. They are employed at big manufacturing companies like car companies and stuff. But probably a lot of government contracts are outrageously priced so there’s probably a lot of cushion. A tech founder who sleeps 4 hours a night is often a better
14:17 < hprmbridge> Eli> investment than a team of MBAs who don’t really lose sleep if the business goes bankrupt. The costs and incentives are different.
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18:28 < hprmbridge> gourneau> https://x.com/p_maverick_b/status/1846221445187469374/photo/1
18:32 < hprmbridge> geraldmahony> If you do research outside of a well funded institute (i.e. your garage). And you build something in biotech potentially useful, with well-designed experiments. But you are unemployed and strapped for cash.  What are your options for peer review?
18:33 < hprmbridge> kanzure> skip peer review
18:33 < hprmbridge> kanzure> is your goal peer review, or is your goal something else like a working system or...?
18:35 < hprmbridge> geraldmahony> To gain credibility. by showing data and defending the experiments through an adversarial/judicial system which does not involve paying large sums of money to a publishing company
18:35 < hprmbridge> kanzure> I'm trying to understand. Your terminal goal is credibility?
18:36 < hprmbridge> geraldmahony> Yes. For the technology I am building!
18:37 < hprmbridge> geraldmahony> I don't want it to be glossed over as just another hobbyist project. I would like for it to be useful to people working on relevant problems that could be significantly enabled by the technology
18:38 < hprmbridge> geraldmahony> I feel like adoption requires publication nowadays
18:38 < hprmbridge> kanzure> okay. I think your approach is very wrong but I don't know much yet. So I might be wrong.
18:38 < hprmbridge> kanzure> by approach I mean how you are navigating this
18:39 < hprmbridge> kanzure> not the actual tech. what is the area of tech or what is the project generally about?
18:39 < hprmbridge> geraldmahony> OK? Which assumptions am I making or where am I going wrong here
18:39 < hprmbridge> kanzure> there is an epic monumentally huge credibility crisis in scientific institutions for one
18:39 < hprmbridge> kanzure> and things get done outside that system all the time.
18:40 < hprmbridge> kanzure> science is very deeply captured by anti-science nutjobs
18:40 < hprmbridge> geraldmahony> Hmm
18:40 < hprmbridge> kanzure> that believe more in reputation than science
18:40 < hprmbridge> geraldmahony> But how many people actually reuse or reproduce tech done outside of an institution?
18:41 < hprmbridge> kanzure> it really depends on the project, sometimes the best way to get people to use something is to sell it to them for money
18:41 < hprmbridge> kanzure> otherwise they wouldn't even bother!
18:42 < hprmbridge> kanzure> it depends. what's your project area?
18:42 < hprmbridge> geraldmahony> New molecular biology
18:42 < hprmbridge> geraldmahony> *Methods or compositions therein
18:43 < hprmbridge> kanzure> what does that mean?
18:43 < hprmbridge> geraldmahony> Like PCR or biochemical reactions of similar broad applicability
18:45 < hprmbridge> kanzure> and you have a publication ready?
18:45 < hprmbridge> geraldmahony> I have no publications.
18:45 < hprmbridge> kanzure> you will likely need to write at least one manuscript or blog post to show off your work.
18:45 < hprmbridge> geraldmahony> Where can I do this? Outside of a journal
18:46 < hprmbridge> kanzure> interwebs. you can self publish by uploading a file.
18:47 < hprmbridge> kanzure> and then post on DIYbio, maybe twitter, talk to a blogger or two, maybe nextbigfuture or synbiobeta
18:47 < hprmbridge> kanzure> you can also post on arxiv.org, but probably not biorxiv.org (dunno)
18:48 < hprmbridge> kanzure> anyway, to get people to use it, you might have to sell a kit
18:49 < hprmbridge> geraldmahony> I wasn't aware that arxiv accepts bio papers
18:50 < hprmbridge> kanzure> there's some weird stuff in there
18:51 < hprmbridge> kanzure> peer review usually isn't that much of a review, it's not like they go check your results in their own experiments
19:02 < hprmbridge> kanzure> another option if you really want academia is to pick a  coauthor
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20:54 < hprmbridge> nmz787> @geraldmahony if your thing is like a theory, that's different than "I discovered this super useful enzyme purification technique", the latter of which could be self-published as a whitepaper which coincides with the "buy it now" button on your website.
20:55 < hprmbridge> nmz787> The more people use it, and if they find its utility self-evident, you can then get people to add testimony or they'll publish for you "we used GERALDMAHONY's kit and here's our amazing results"
20:56 < hprmbridge> nmz787> If they publish, I think you're then allowed to for example say "used by Harvard [1]" etc
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--- Log closed Wed Oct 16 00:00:21 2024