--- Log opened Sat Nov 09 00:00:44 2024 00:06 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Ping timeout: 264 seconds] 00:58 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 01:38 < hprmbridge> kanzure> apitegromab 02:00 < fenn> .wik apitegromab 02:00 < saxo> "Apitegromab (SRK-015) is a fully human monoclonal antibody developed to treat spinal muscular atrophy. It works by binding to and inhibiting promyostatin, a precursor to myostatin, which limits the size of skeletal muscle tissue, as well as inactive myostatin." - https://en.wikipedia.org/wiki/Apitegromab 03:09 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap 04:03 -!- justanot1 [~justanoth@gateway/tor-sasl/justanotheruser] has joined #hplusroadmap 04:04 -!- justanotheruser [~justanoth@gateway/tor-sasl/justanotheruser] has quit [Ping timeout: 260 seconds] 06:16 -!- TMM [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.] 06:16 -!- TMM [hp@amanda.tmm.cx] has joined #hplusroadmap 08:38 -!- etc-vi [~etc-vi@user/meow/girlchunks] has quit [Ping timeout: 245 seconds] 09:31 -!- etc-vi [~etc-vi@user/meow/girlchunks] has joined #hplusroadmap 09:45 -!- nsh [~lol@user/nsh] has quit [Quit: ZNC - http://znc.in] 09:47 -!- nsh [~lol@user/nsh] has joined #hplusroadmap 10:29 -!- Malvolio [~Malvolio@idlerpg/player/Malvolio] has quit [Read error: Connection reset by peer] 10:34 -!- nsh [~lol@user/nsh] has quit [Quit: ZNC - http://znc.in] 10:37 -!- nsh [~lol@user/nsh] has joined #hplusroadmap 10:41 -!- RangerMauve [m-4bpbmo@matrix.mauve.moe] has quit [Remote host closed the connection] 10:43 -!- RangerMauve [m-4bpbmo@matrix.mauve.moe] has joined #hplusroadmap 10:44 -!- Malvolio [~Malvolio@idlerpg/player/Malvolio] has joined #hplusroadmap 11:34 -!- superkuh [~superkuh@user/superkuh] has quit [Read error: Connection reset by peer] 11:36 -!- superkuh [~superkuh@user/superkuh] has joined #hplusroadmap 12:13 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Remote host closed the connection] 12:13 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap 14:03 < nsh> .m https://x.com/MysteryHacker1/status/1855370618260078875 14:03 < AugustaAva> ​twitter: dis u? https://video.twimg.com/ext_tw_video/1855370460869038080/pu/vid/avc1/480x272/mWsMHrI6NXq2KaE8.mp4?tag=12 [https://twitter.com/Nature/status/1855079763129299141 A scientist who successfully treated her own breast cancer by injecting the tumour with lab-grown viruses has sparked discussion about the ethics of self-experimentation https://go.nature.com/3NXqzEq ] 14:05 < kanzure> see 14:05 < kanzure> see https://arep.med.harvard.edu/pdf/Hanley_Bain_Church_2018.pdf 14:06 < kanzure> "In 2014, Philip Kennedy had electrodes implanted into his speech center to further his research on direct brain interfaces.[8] His first operation to implant electrodes into his speech center caused him to lose the ability to speak, but he did recover." 14:15 * nsh nods 14:17 < kanzure> i think a more interesting discussion would be the ethics of choosing not to do self-experimentation, like the ethical implications of being a coward or something 14:17 < kanzure> otherwise it's just all the usual ethics arguments, which eveyrone knows ad nauseaum already 15:37 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Ping timeout: 244 seconds] 15:44 < hprmbridge> geraldmahony> the skill cap for doing this kind of thing is high enough that the concern for self-harm by imitation is low. Moreover it requires a committed mind to do it to oneself 16:54 < hprmbridge> kanzure> https://www.astralcodexten.com/p/book-review-from-oversight-to-overkill 16:58 < L29Ah> article: https://pmc.ncbi.nlm.nih.gov/articles/PMC11435696/ 16:59 < L29Ah> > The patient, who is also an expert virologist, anticipating that the recurrent tumour would be of TNBC phenotype for which therapies of only limited efficacies exist, informed her oncologists that she was going to treat this tumour by the i.t. administration of viruses similar to oncolytic viruses (that were in clinical development for BC) before undergoing any other treatment. 16:59 < L29Ah> kinda reckless 17:00 < jrayhawk> would've been useless unconvincing data for a case report if she'd done anything else first. 17:00 < L29Ah> although i must say the usual treatment for recurrent cancer isn't great 17:00 < L29Ah> yeah 17:04 < L29Ah> Croatia, huh 20:15 -!- mxz_ [~mxz@user/mxz] has quit [Ping timeout: 248 seconds] 20:15 -!- mxz_ [~mxz@user/mxz] has joined #hplusroadmap 20:16 -!- mxz [~mxz@user/mxz] has quit [Ping timeout: 248 seconds] 20:16 -!- mxz_ is now known as mxz 21:10 < hprmbridge> kanzure> https://cdn.discordapp.com/attachments/1064664282450628710/1305036857301532693/image0.png?ex=673191c9&is=67304049&hm=582b95988608a894ffbf4fb8b3dd85d6aaf724284304c8e20bb7a29ba021b250& 21:12 < hprmbridge> kanzure> for fenn https://x.com/ID_AA_Carmack/status/1855324253295403182 21:42 < fenn> .m https://x.com/ID_AA_Carmack/status/1855324253295403182 21:42 < AugustaAva> ​twitter: Someone should make a proxy system to simulate mars latency and projected bandwidth and start figuring out how to make effective use of the internet from mars. Good hobby project. ␤ ␤ Easy to imagine individual apps or sites optimized for offline use, but how do you take advantage [https://twitter.com/elonmusk/status/1854915519100707092 21:42 < AugustaAva> ​This is just a very basic first step. ␤ ␤ Earth and Mars will ultimately need >petabit/sec connectivity. ] 21:42 < fenn> yeah i've been saying that for years 21:43 < fenn> realistically the best way is to just have local mirrors of everything and ship wholesale data via rocket 21:44 < fenn> interplanetary links will always be a big bandwidth constraint 21:45 < fenn> i was hoping one of the many mars analog crew members would do a software project to strip out all the unnecessary round trip handshakes, like a proxy server 22:23 -!- mxz_ [~mxz@user/mxz] has joined #hplusroadmap 23:31 < alethkit> Is it worth going into a PhD to get access to research equipment, or are there easier ways of getting access? 23:48 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap --- Log closed Sun Nov 10 00:00:45 2024