--- Log opened Wed Nov 13 00:00:48 2024 02:18 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has joined #hplusroadmap 02:21 -!- AugustaAva [~x@193.29.58.204] has joined #hplusroadmap 02:22 -!- AugustaAva [~x@193.29.58.204] has quit [Remote host closed the connection] 02:23 -!- AugustaAva [~x@193.29.58.204] has joined #hplusroadmap 02:23 -!- AugustaAva [~x@193.29.58.204] has quit [Remote host closed the connection] 02:26 -!- AugustaAva [~x@193.29.58.204] has joined #hplusroadmap 03:20 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 04:45 -!- Malvolio [~Malvolio@idlerpg/player/Malvolio] has quit [Ping timeout: 252 seconds] 04:56 < kanzure> hmph 04:59 -!- Malvolio [~Malvolio@idlerpg/player/Malvolio] has joined #hplusroadmap 05:42 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Read error: Connection reset by peer] 05:43 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 05:58 < kanzure> computational recipe representation again https://news.ycombinator.com/item?id=42066358 06:03 -!- archels [~neuralnet@static.65.156.69.159.clients.your-server.de] has quit [Ping timeout: 276 seconds] 06:03 -!- saxo [~saxo@zug.infomesh.net] has quit [Ping timeout: 252 seconds] 06:04 -!- yorick [~yorick@user/yorick] has quit [Ping timeout: 252 seconds] 06:05 -!- archels [~neuralnet@static.65.156.69.159.clients.your-server.de] has joined #hplusroadmap 06:05 -!- yorick [~yorick@user/yorick] has joined #hplusroadmap 06:05 -!- saxo [~saxo@zug.infomesh.net] has joined #hplusroadmap 06:13 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Read error: Connection reset by peer] 06:14 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 06:37 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has quit [Ping timeout: 264 seconds] 07:50 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 07:54 < L29Ah> .t https://www.nature.com/articles/d41586-024-03708-4 07:54 < saxo> AI protein-prediction tool AlphaFold3 is now open source 09:58 < kanzure> status games around IQ https://x.com/ekrii3/status/1856262206024827321 10:27 < geneh2> Adrian Bowyer's deleting their twitter, does anyone have that archived? 10:37 < kanzure> not me 13:00 < kanzure> are there any flexible electronics versions of SSD storage, like spooled tape but SSD? 13:13 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has left #hplusroadmap [] 13:15 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 13:34 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has left #hplusroadmap [] 14:03 < hprmbridge> Lev> kanzure: I think there's been some research on flash memory on flexible substrates, but idk bout ssd 14:04 < hprmbridge> Lev> plus I'm willing to put bets on 3DNAND not existing in a flexible format 14:39 -!- TMM [hp@amanda.tmm.cx] has quit [Quit: https://quassel-irc.org - Chat comfortably. Anywhere.] 14:39 -!- TMM [hp@amanda.tmm.cx] has joined #hplusroadmap 14:47 -!- L29Ah [~L29Ah@wikipedia/L29Ah] has joined #hplusroadmap 14:51 < L29Ah> .t https://nypost.com/2024/11/13/business/fbi-seizes-polymarket-ceos-phone-electronics-after-betting-platform-predicts-trump-win-source/ 14:51 < saxo> Exclusive | FBI seizes Polymarket CEO's phone, electronics after betting platform predicts Trump win: source 15:13 -!- gl00ten [~gl00ten@bl5-237-194.dsl.telepac.pt] has joined #hplusroadmap 15:16 -!- gl00ten [~gl00ten@bl5-237-194.dsl.telepac.pt] has quit [Remote host closed the connection] 15:28 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has quit [Ping timeout: 260 seconds] 15:40 -!- Gooberpatrol66 [~Gooberpat@user/gooberpatrol66] has joined #hplusroadmap 15:57 < nsh> .m https://x.com/ShangguanJiewen/status/1856551954387759528 15:57 < AugustaAva> ​twitter: Chinese scientists at Shanghai Jiao Tong, working with MIT, engineered a new desalination device. It turns seawater into drinkable water at a rate higher than any other device. The system is passive, & solar-powered. ␤ ␤ A system the size of a small suitcase meets the daily needs of https://pbs.twimg.com/media/GcPMJ2LasAUJkgg.jpg 16:02 -!- TC [~talinck@76-230-66-1.lightspeed.cntmoh.sbcglobal.net] has quit [Read error: Connection reset by peer] 18:29 -!- darsie [~darsie@84-112-12-36.cable.dynamic.surfer.at] has quit [Ping timeout: 252 seconds] 19:40 < hprmbridge> Eli> @jrayhawk I recently finished up my rough draft on my last paper and am waiting for review and I started looking into the idea of anti-oxidants being cytoprotective for cancer for my next paper. The evidence seems so overwhelmingly in favor of this idea that I'm not sure I would be providing anyone any benefit by writing about it. The only thing I would be providing is connecting the nrf2 pathway 19:40 < hprmbridge> Eli> to the giant failed CARET and ATBC trials in the 90s. For whatever reason, cancer researchers seem to know about the nrf2 pathway being cytoprotective for cancer, but it seems like there are maybe only a few people have connected it to these trials and they don't appear to have written a review about it. I'm not sure if this constitutes a research gap that should be written about? 19:42 < hprmbridge> Eli> Maybe I need to email some of the researchers in the field and see if anyone would even care. Seems like the number of cancer papers is huge? 19:43 < jrayhawk> Brief comments can get published, too. Getting it into the citation graph can have some value. 19:46 < hprmbridge> Eli> Yeah, I need to see if anyone else has written enough about this topic. It seems obvious that nutritional therapy would likely increase survival time. Like, connecting the nrf2 pathway with the giant trials in the 90s should give us predictive value about which foods to eat during lung cancer. So, maybe that seems like it would be valuable ...? 19:54 < jrayhawk> yeah, reading papers would be a good idea. the part where you're connecting old trials to more recently broadly accepted mechanism and theory is probably worthwhile, trying to claim that the field has not discovered the differential benefit of glutathione and nrf2 to cancer survival and propagation is... offputting to people who do read papers. 19:55 < jrayhawk> like, these ideas have been floating around since warburg's time, and industry, academia, and government have shoved many billions of dollars into how to optimize chemo. 20:11 -!- mxz__ [~mxz@user/mxz] has joined #hplusroadmap 20:11 -!- mxz [~mxz@user/mxz] has quit [Ping timeout: 252 seconds] 20:11 -!- mxz__ is now known as mxz 20:12 -!- mxz_ [~mxz@user/mxz] has quit [Ping timeout: 255 seconds] 20:28 < hprmbridge> Eli> Sorry. By "not making the connection", I just mean that the people trying to figure out the CARET and ATBC trials increase in lung cancer haven't seemed to make the connection. There have been a number of older papers hypothesizing the MOA of the increase in lung cancer from the trials, but they are super all over the place and not super convincing to me. 20:30 < hprmbridge> Eli> BTW, I just ran across this and it seems a bit crazy. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30736-8 20:34 < hprmbridge> Eli> Like, the statins are decreasing brown adipose fat, but they are supposed to prevent ASCVD. So, you've potentially got reduced COQ10 and reduced BAT, which, seems like it would be fighting against the goal of reducing ASCVD. If the paper is legit, it seems not great. 20:40 < jrayhawk> what's the DOI for that? 20:46 < hprmbridge> Eli> 10.1016/j.cmet.2018.11.017 20:46 < hprmbridge> Eli> paper here: https://www.cell.com/action/showPdf?pii=S1550-4131%2818%2930736-8 21:48 < jrayhawk> https://libgen.is/scimag/10.1016%2Fj.cmet.2018.11.017 21:51 < jrayhawk> statin companies pushing the lipid hypothesis would, of course, claim that lowered fatty acid metabolism is evidence that fatty acid transport has decreased 22:18 -!- mxz_ [~mxz@user/mxz] has joined #hplusroadmap --- Log closed Thu Nov 14 00:00:49 2024