--- Log opened Thu Nov 28 00:00:02 2024
02:17 < TMA> L29Ah: fenn: published sci-fi is written by current meatbags for current meatbags. current meatbags are generally not interested in transcending their meatbagness (this group notwithstanding)
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16:30 < fenn> .t https://davidlang.substack.com/p/costs
16:30 < saxo> What should science cost? - by David Lang
16:31 < fenn> mass production or even serial handbuilt tools would greatly reduce costs and expand access to cutting edge science tools
16:32 < fenn> instead of like, ONE telescope you could have a dozen, that's 12X the data
16:32 < fenn> most of the costs are engineering and design, often lumped into "manufacturing" because people neglect to consider the thought that goes into fixturing and tooling a one-off
17:05 < fenn> https://www.open-raman.org/ $3k raman spectrometer built from off the shelf optical components
17:06 < fenn> still too expensive IMHO
17:10 < fenn> if laser spectral width is the expensive part, use a diffraction grating and collimator to get rid of the off-peak wavelengths
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17:16 < fenn> ok i looked at the BOM, it's expensive just because everything is thorlabs. e.g. a 5V power supply is $83
17:31 < fenn> https://github.com/PaddlePaddle/PaddleHelix an open source AlphaFold-3 clone for protein structure prediction, allegedly, although the demo is down
17:32 < fenn> "non commercial"
17:32 < fenn> one wonders how they would check
17:33 < fenn> the model is ~1.3GB
17:35 < fenn> ... and you need 190 to 415GB of compressed genetic database in order to run it
17:35 < fenn> i thought alphafold was just sequence -> structure so i wonder what the database is for
17:42 < fenn> needs 32GB of VRAM
17:42 < fenn> seems like this could use a bit of quantization
17:44 < fenn> hmm maybe can just reduce the batch size
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--- Log closed Fri Nov 29 00:00:03 2024