--- Log opened Thu Jan 23 00:00:56 2025
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08:23 < zo3> what would you say is an example practical application for biohacking/transhumanism
08:23 < hprmbridge> kanzure> practical at what level or to who?
08:25 < zo3> for anyone who would be interested in modification really
08:25 < kanzure> it's a very broad area.
08:26 < kanzure> for example, would you consider modern xenotransplantation practice to be practical?
08:29 < zo3> depends on what you get out of doing it. by practical i mean useful and not easy to do
08:32 < kanzure> programmable self-replicating machines would be nice to have, you could have self-replicating machine shops that make ~anything
08:33 < kanzure> not currently practical because nobody knows how to make a "completely" self-replicating machine, but many parts of many machines are presently replicable
08:33 < kanzure> DNA synthesis is a favorite one of mine, as a method for creating synthetic (never before existed) genetic material for reprogramming biological cells
08:34 < zo3> interesting ^^
08:34 < zo3> thank you for the answer
08:34 < kanzure> have you seen the wiki for this channel? https://diyhpl.us/wiki/hplusroadmap
08:34 < kanzure> we have a list of potential human genetic engineering targets too https://diyhpl.us/wiki/genetic-modifications/
08:36 < zo3> i have not! thx <3 
08:37 < zo3> i don't know a lot about this stuff. i just know my friend was kinda interested at one point
08:37 < kanzure> cool. what brings you here?
08:39 < kanzure> at some level a question like "what is the practical application of transhumanism" is like asking "what is the practical application of technology development to assist, upgrade, transform, or modify the human condition" and the answer can be very broad, such as technology producing a deflationary effect on the price of improvements to individual human conditions.
08:40 < zo3> I fuck with the concept. I dig computers and figure in a lot of ways the human body is just a fleshy equivalent
08:40 < zo3> right. that makes sense
08:41 < kanzure> much of biological science has focused on the amelioration of human disease, instead of on "positive" biology if you will-- trying to figure out what works well and how to make it work even better.
08:41 < kanzure> much research investment has gone into disease and figuring out the etiology of human bioloigcal defecits, which sometimes by accident happens to produce transhumanist knowledge, so that's nice i guess, but slowgoing at a societal scale
08:42 < kanzure> intentionally trying to improve human biology, neurology, genetics, etc is often "off limits" or disallowed, although still possible to carve out unique situations to move things forward here and there
08:43 < zo3> people certainly have a "if it isn't broke, don't fix it" mentality 
08:44 < kanzure> https://www.mrob.com/pub/religion/extro_prin.html
08:45 < zo3> have you done any personal modifications? or is this a more theoretical thing for you
08:47 < kanzure> there are no modifications available at this time that are sufficiently powerful to interest me, although i do have an R&D interest in changing that
08:48 < kanzure> for example, brain implants are computationally underpowered and have very minimal bandwidth; requires chip design and has a few other issues.
08:48 < kanzure> germline modifications are interesting and practical (see the link above), although these modifications can't apply to living human adults
08:50 < kanzure> probably the most practical intervention for human adults is anabolic steroids, and for children it's human growth hormone
08:53 < zo3> implants are really interesting to me but i could see them becoming an issue. mfw my neurolink plays the daily ad 
08:53 < kanzure> he artificial heart is very cool!
08:53 < kanzure> the^
08:54 < zo3> obviously the issue is it being closed source or by a bad company but that seems probable 
08:54 < zo3> oh yeah, that does seem awesome 
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09:28 < juri_> We're not all so close to wet things, sadly. I spend my time on 3D printing, and AI related problems.
09:29 < juri_> (AKA, i'm pretty off-topic skill wise, but on-topic goals wise. I think?)
09:33 < zo3> ah cool. what do you 3d print
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10:39 < docl> at the edge between biohacking and conventional medicine, one thing I'd like to see is small implants that deliver doses of molecules with high precision with good sensors for feedback. I think this could be useful for hacking and maintaining homeostasis (although it needs replacement/refills). there's an overall lack of precision in dose delivery in current medicine that concerns me. if you could 
10:39 < docl> ensure no spike in abundance/availability in the bloodstream, more drugs would work on more things. there are also potential biosynthetic and synthetic routes to make small devices that make their own drugs from molecules that are abundant in blood serum. so in principle you could combine a small drug factory with a high precision dosage contral mechanism.
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11:30 < AlonzoC> kanzure: what is the current state of the art with artifical heart research?
13:32 < kanzure> https://kamilstanuch.github.io/LLM-token-generation-simulator/
14:07 < AlonzoC> kanzure: sorry to reiterate a question for you from when you were offline, but what is the current SOTA in the realm of artifical hearts? Got a good place in the lit to start?
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14:12 < kanzure> don't know
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16:13 < andytoshi> this looks like a cool series https://profmattstrassler.com/2025/01/16/double-trouble-the-quantum-two-slit-experiment-1/
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17:02 < hprmbridge> kanzure> https://www.corememory.com/p/science-corp-aims-to-plant-ideas
17:04 < fenn> .m https://x.com/drjimfan/status/1881353126210687089
17:05 < fenn> much underwear being laundered across silicon valley this week with "panic mode" following deepseek-r1
17:07 < fenn> "every single "leader" of gen ai org is making more than what it cost to trained deepseek v3 entirely, and we have dozens of such "leaders"
17:08 < fenn> says anonymous at meta
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17:13 < hprmbridge> kanzure> is nvidia digits worthwhile?
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19:17 < fenn> i can't find any specs on the DIGITS memory bandwidth. i vaguely recall seeing a number around 256 GB/s which is not especially good for LLM stuff. the box has a lot of compute, which would be useful for video generation or training small models, but do you do $3k worth of either of those? probably not
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--- Log closed Fri Jan 24 00:00:57 2025